Abstract: Techniques related to temporary setpoint values are disclosed. The techniques may involve causing operation of a fluid delivery device in a closed-loop mode for automatically delivering fluid based on a difference between a first setpoint value and an analyte concentration value during operation of the fluid delivery device in the closed-loop mode. Additionally, the techniques may involve obtaining a second setpoint value. The second setpoint value may be a temporary setpoint value to be used for a period of time to regulate fluid delivery, and the second setpoint value may be greater than the first setpoint value. The techniques may further involve causing operation of the fluid delivery device for automatically reducing fluid delivery for the period of time based on the second setpoint value.

Abstract: One or more processors may be configured to detect whether a patient with diabetes is operating a vehicle based on one or more detected gestures. Based on the detection of operating the vehicle, the one or more processors may cause a patient device to output alerts according to a driving alert protocol. In another example, based on the detection of operating the vehicle, one or more processors may cause an insulin pump to operate according to a driving therapy protocol.

Abstract: A medical device system and related methods of automatically adjusting control parameters of a medical device are disclosed. One method involves obtaining data pertaining to a physiological condition of a patient during operation of the medical device in accordance with the operating mode, determining a plurality of adjusted values for the control parameter based at least in part on the data, determining a respective cost associated with each respective adjusted value for the control parameter based at least in part on the data using a cost function, identifying, from among the plurality of adjusted values, an optimized value from among the plurality of adjusted values, wherein the optimized value has a minimum cost associated therewith from among the plurality of costs, and updating the control parameter at the medical device to the optimized value.

Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

Abstract: Embodiments of the invention provide amperometric analyte sensors having elements selected to optimize enzymatic activities associated with such sensors including polymers functionalized with enzymatic mediators as well as methods for making and using such sensors. While embodiments of the invention can be used in a variety of contexts, typical embodiments of the invention include glucose or ketone sensors used in the management of diabetes.

Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic—cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

Abstract: Disclosed herein are techniques related to glucose estimation without continuous glucose monitoring. In some embodiments, the techniques may involve receiving input data associated with a user. The input data may comprise discrete blood glucose measurement data associated with the user, activity data associated with the user, contextual data associated with the user, or a combination thereof. The techniques may also involve using an estimation model and the input data associated with the user to generate one or more estimated blood glucose values associated with the user.

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Abstract: An electronic medical device is disclosed here. An exemplary embodiment of the medical device includes a printed circuit board assembly, a protective inner shell surrounding at least a portion of the printed circuit board assembly, and an outer shell surrounding at least a portion of the protective inner shell. The printed circuit board assembly has a printed circuit board, electronic components mounted to the printed circuit board, a battery mounted to the printed circuit board, and an interface compatible with a physiological characteristic sensor component. The protective inner shell is formed by overmolding the printed circuit board assembly with a first material having low pressure and low temperature molding properties. The outer shell is formed by overmolding the protective inner shell with a second material that is different than the first material.

Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects.

Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.

Abstract: A linear voltage regulator with isolated supply current is disclosed. The voltage regulator is configured and controlled such that its output current closely matches its input current (any quiescent current consumed by the regulator is negligible relative to the amount of current passed by the regulator). In certain implementations, the voltage regulator is implemented as an analog component. In other implementations, the voltage regulator includes or cooperates with digital elements, such as an analog-to-digital converter, a digital processing core, or a digital-to-analog converter.

Abstract: Disclosed are techniques including accessing historical physiological data of a person; presenting a graph view of a historical time period, where the graph view includes at least a portion of the historical physiological data plotted over the historical time period and includes one or more historical events which occurred during the historical time period; receiving user input indicative of a marker for an event, of the one or more historical events, being adjusted from a first position in the historical time period to a second position in the historical time period; responsive to receiving the user input, accessing adjusted physiological data for the person from at least the time point in the historical time period to an end of the historical time period, where the adjusted physiological data has been determined based on the adjusted marker for the event marker and a physiological model for the person; and presenting the adjusted physiological data.

Abstract: A medical device includes a sensor to observe a characteristic of an anatomy, and a sensor base coupled to the sensor. The medical device includes a coupling system to couple the sensor base to the anatomy. The coupling system includes a first adhesive member and a second adhesive member. The first adhesive member is coupled to the sensor base and the second adhesive member is to couple to the anatomy. The first adhesive member includes at least one cut-out to direct moisture to an ambient environment surrounding the medical device.

Abstract: Disclosed herein are techniques related to insertion of a fluid conduit (e.g., tubing connected to a fluid reservoir or a cannula sharing a pre-assembled fluid pathway with such tubing). In some embodiments, an insertion mechanism may include one or more springs (e.g., a torsion spring or a compression spring). The one or more springs may cause a trocar or a trocar slider to pierce tissue and insert the fluid conduit. The one or more springs may further cause the trocar or the trocar slider to be removed from the tissue.

Abstract: A method for automatically configuring a medical device with user-specific configuration data includes obtaining, by a charger device from one or more server computing devices, user-specific configuration data stored on a first medical device that is configured to provide therapy to a patient in accordance with the user-specific configuration data, and causing, by the charger device, configuration of a second medical device based on communicating the user-specific configuration data to the second medical device while the second medical device is being charged by the charger device, wherein the second medical device is a replacement device for the first medical device.

Abstract: Intelligent (smart) tracking accessories for a medicine dispensing device, such as an injection pen or pen device, are described. A smart tracking accessory in the form of a smart cap for a medicine dispensing device, such as an insulin pen, is configured to protect the needle of the dispensing device and the medicine contained therein when the device is not in use. The smart cap may detect the presence of the medicine dispensing device, detect an activation event such as removal from the medicine dispensing device, inform the user whether it is safe to administer a therapeutic dose of medicine, and log occurrence of the dosing event.

Abstract: An infusion device configured to implant a cannula and a sensor in a user. The infusion device includes a first unit defining a first housing and a second unit defining a second housing. The second housing is configured to engage the first housing. The infusion device includes a first insertion needle configured to implant the cannula in the user and a second insertion needle configured to implant the sensor in the user when the second unit engages the first unit. The infusion device includes processing circuitry in electrical communication with the sensor and a fluid reservoir in fluid communication with the cannula. In examples, the first unit and the second unit are configured to engage using an inserter.

Abstract: Devices, systems, and techniques for therapy delivery and healthcare management is described. In one example, a system comprises a delivery device configured to execute therapy information comprising a treatment schedule specifying one or more treatments over a time period, wherein for each of the one or more treatments, the therapy information comprises a treatment type and a treatment amount; and processing circuitry configured to: determine a modification to the therapy information based on a recommendation of a digital twin, wherein the digital twin determines an estimated glucose level expected to be within a healthy range if the delivery device executes the modification to therapy information; and in response to physician review of the modification to the therapy information, output, to a healthcare provider system for the patient, data indicating completion of a healthcare service corresponding to the physician review.