Abstract: The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-proGHRH or the canine GHRH which can be used to treat disease and growth hormone deficiencies by gene therapy in vertebrates, in particular in dogs.
Type:
Grant
Filed:
December 17, 2004
Date of Patent:
December 23, 2008
Assignee:
Meial Limited
Inventors:
Laurent Bernard Fisher, Nathalie Michele Cachet, Simona Barzu-Le-Roux