Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
Type:
Application
Filed:
December 8, 2006
Publication date:
May 6, 2010
Applicant:
Meibergdreef 9
Inventors:
Hergen Spits, Ferenc A. Scheeren, Sean A. Diehl