Patents Assigned to Meiji Seika Kaisha, Ltd.
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Patent number: 9469863Abstract: The present invention relates to novel aminoglycoside antibiotics, a process for producing the same, and pharmaceutical use thereof. More specifically, the present invention relates to compounds represented by formula (I), a process for producing the same, and use of the same as antimicrobial agents. wherein R represents amino or hydroxyl.Type: GrantFiled: December 1, 2008Date of Patent: October 18, 2016Assignee: MEIJI SEIKA KAISHA, LTD.Inventors: Naomi Sumida, Koji Yanai, Masato Tani, Takayoshi Fukushima, Yasumasa Ota, Shuichi Gomi, Akitaka Nakane
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Patent number: 9260375Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: GrantFiled: November 29, 2011Date of Patent: February 16, 2016Assignee: Meiji Seika Kaisha, Ltd.Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Publication number: 20130022603Abstract: Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype I and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.Type: ApplicationFiled: February 18, 2011Publication date: January 24, 2013Applicants: SYMPHOGEN A/S, MEIJI SEIKA KAISHA, LTD.Inventors: Jiro Tanaka, Peter Sejer Andersen, Takafumi Okutomi, Tsuneyoshi Inaba, Keiko Otsuka, Hirotomo Akabane, Yukari Hoshina, Hiroshi Nagaso, Masashi Kumagai
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Patent number: 8344154Abstract: 2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant Streptococcus pneumoniae (PRSP), Haemophilus influenzae including ?-lactamase-negative, ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.Type: GrantFiled: February 4, 2010Date of Patent: January 1, 2013Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takahisa Maruyama, Yuko Kano, Takashi Ando, Toshiro Sasaki, Kazuhiro Aihara, Toshiki Fujita
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Patent number: 8324427Abstract: An objective of the present invention is to provide agricultural and horticultural disease control agents that have potent control effect against plant diseases and, at the same time, have high photostability. The agricultural and horticultural disease control agents comprise a novel substance analogous to MK8383 as an active ingredient.Type: GrantFiled: March 11, 2009Date of Patent: December 4, 2012Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kentaro Yamamoto, Nobuto Minowa, Masahisa Nakada
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Patent number: 8097708Abstract: [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae, erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.Type: GrantFiled: February 7, 2007Date of Patent: January 17, 2012Assignees: Taisho Pharmaceutical Co., Ltd., Meiji Seika Kaisha, Ltd.Inventors: Tomohiro Sugimoto, Kanako Yamamoto, Akira Manaka, Haruhisa Ogita, Jun Kurosaka, Madoka Kawamura, Masato Kashimura, Naoki Sasamoto, Tomoaki Miura, Kenichi Kanemoto, Tomohiro Ozawa, Ken Chikauchi, Eiki Shitara, Dai Kubota
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Patent number: 8093294Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: GrantFiled: August 10, 2007Date of Patent: January 10, 2012Assignee: Meiji Seika Kaisha, Ltd.Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Patent number: 8084044Abstract: An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.Type: GrantFiled: March 30, 2007Date of Patent: December 27, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Jiro Tanaka, Fukuichi Ohsawa, Takafumi Okutomi, Hiroshi Nagaso, Masashi Kumagai, Takahisa Suzuki, Keiko Otsuka
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Patent number: 8071153Abstract: Disclosed are whey protein-containing granules which can dissolve a whey protein into water without forming insoluble lumps thereby making a solution containing the dissolved whey protein clear without turbidity, and a method for producing the same. The whey protein-containing granules are composed of a polyglycerin fatty acid ester having HLB of 13 to 18 and containing lauric acid as a constituent fatty acid. As the polyglycerin fatty acid ester, for example, monolauric acid decaglycerin ester or monolauric acid pentaglycerin ester may be used.Type: GrantFiled: April 17, 2007Date of Patent: December 6, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takuya Kodama, Akio Tanaka, Tetsuya Magarikaji
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Patent number: 8058247Abstract: An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.Type: GrantFiled: February 11, 2009Date of Patent: November 15, 2011Assignees: Microbial Chemistry Research Foundation, Meiji Seika Kaisha, Ltd.Inventors: Yoshiaki Takahashi, Masayuki Igarashi
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Patent number: 8030052Abstract: A midecamycin hyper producing strain having improved productivity of midecamycin which is a member of macrolide antibiotics, and a method for producing midecamycins using the strain are provided. The midecamycin producing actinomycetes comprises a midecamycin biosynthesis gene or a homologue thereof, wherein at least one module in a polyketide synthase gene of a midecamycin biosynthesis gene or partial sequences of the at least one module, is substituted so as to encode the corresponding amino acid sequences of the other module.Type: GrantFiled: March 29, 2006Date of Patent: October 4, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Manabu Watanabe, Masaaki Nakahashi
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Publication number: 20110237784Abstract: A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).Type: ApplicationFiled: August 6, 2008Publication date: September 29, 2011Applicants: TAISHO PHARMACEUTICAL CO., LTD., MEIJI SEIKA KAISHA, LTD.Inventors: Tomohiro Sugimoto, Kanako Yamamoto, Jun Kurosaka, Naoki Sasamoto, Masato Kashimura, Tomoaki Miura, Kenichi Kanemoto, Tomohiro Ozawa, Ken Chikauchi, Eiki Shitara
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Patent number: 8017797Abstract: A method for efficiently producing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, useful as a production intermediate of herbicide L-AMPB. The method comprises using a compound represented by the below formula (4): (4) where R1 represents a C1-4 alkyl group, arylmethyl group, or substituted arylmethyl group.Type: GrantFiled: March 21, 2008Date of Patent: September 13, 2011Assignee: Meiji Seika Kaisha Ltd.Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi
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Publication number: 20110171698Abstract: ?-Amyrin, a precursor in biosynthesis of soyasapogenol B, is biosynthesized by cyclization of 2,3-oxidosqualene which is generated by the mevalonate pathway, and soyasapogenol B is biosynthesized by two hydroxylations of ?-amyrin. However, a gene of 22-hydroxylase involved in the sequence of reactions has not been identified. The present inventors identified a gene encoding the hydroxylase for oleanene triterpenes at C-22, and found that oleanene triterpenes could be hydroxylated at C-22 by co-expressing this gene together with one or more specific genes. Further, the present inventors found that soyasapogenol B could be efficiently produced in large quantities by co-expressing this gene for 22-hydroxylase with a gene for 24-hydroxylase.Type: ApplicationFiled: January 20, 2010Publication date: July 14, 2011Applicant: MEIJI SEIKA KAISHA, LTD.Inventors: Yutaka Ebizuka, Masaaki Shibuya, Eriko Wakita
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Publication number: 20110172433Abstract: [Technical Problem] To provide a novel imino derivative capable of being an insecticide compound having excellent characteristics such as sustained effects and broad spectrum. [Solution to Problem] To provide an imino derivative represented by Formula (1). wherein “Ar” denotes a heterocyclic group which may have a substituent on the ring; “X” denotes a sulfur atom or CH2, NR; “R” denotes a hydrogen atom or an alkyl group; “Y” is selected from COR1 or CONR3R4, CONHCOR5, CO2R9; and each of “R1”, “R3”, “R4”, “R5”, and “R9” denotes a hydrogen atom or a certain substituent.Type: ApplicationFiled: July 1, 2009Publication date: July 14, 2011Applicants: MEIJI SEIKA KAISHA, LTD., GIFU UNIVERSITYInventors: Shinzo Kagabu, Masaru Mori, Satoru Kumazawa
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Publication number: 20110152239Abstract: The present invention relates to a process for preparing compositions of high concentrations of omega-3 fatty acids from krill. Furthermore, the invention relates to a composition comprising high concentrations of omega-3 fatty acids, and a lipid fraction from krill comprising high amounts of the fatty acids with chain length C14 and C 16.Type: ApplicationFiled: May 15, 2009Publication date: June 23, 2011Applicants: TAISHO PHARMACEUTICAL CO., LTD., MEIJI SEIKA KAISHA, LTD.Inventors: Tomohiro Sugimoto, Kanako Yamamoto, Jun Kurosaka, Naoki Sasamoto, Masato Kashimura, Tomoaki Miura, Kenichi Kanemoto, Satoshi Yoshida, Kou Kumura, Keiichi Ajito
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Patent number: 7955789Abstract: An object of the present invention is to provide an adhesion-preventing material which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and produced with ease and has high practical utility, as well as to a process for preventing adhesion by using the adhesion-preventing material. The present invention provides (1) an adhesion-preventing material comprising a crosslinked water absorbent poly-?-glutamic acid as an effective ingredient; (2) the adhesion-preventing material described above, wherein the crosslinked water absorbent poly-?-glutamic acid is in the form of powder having a water absorption coefficient in the range of 800-2000; (3) a process for preventing organ from adhesion, comprising a step of bringing the adhesion-preventing material described above into contact with the surface of a local organ; and (4) the process for preventing adhesion described above, wherein the surface of the local organ is in wet state.Type: GrantFiled: November 17, 2005Date of Patent: June 7, 2011Assignees: Keio University, Meiji Seika Kaisha, Ltd.Inventors: Yotaro Izumi, Masafumi Kawamura, Koichi Kobayashi
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Patent number: 7910089Abstract: A sialogogue characterized by comprising polyglutamic acid or its salt. This sialogogue is blended into an oral composition and a food product. This sialogogue is capable of rendering the oral mucosa pleasant even in the case of severe xerostomia.Type: GrantFiled: November 16, 2004Date of Patent: March 22, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazumichi Uotani, Hidetoshi Kubota, Hiroya Endou, Fumihiko Tokita
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Patent number: 7910575Abstract: The present invention provides a pharmaceutical composition for use in the prophylaxis or treatment of allergic ophthalmic diseases or allergic nasal diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzazepine, 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention has few side effects, exerts strong prophylactic and therapeutic effects in the late phase exhibiting pharmaceutical resistance to conventional instillations, and can be used appropriately for topical applications.Type: GrantFiled: March 2, 2007Date of Patent: March 22, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takashi Shishikura, Tsuneyoshi Inaba, Yukari Hoshina, Hirotomo Akabane, Mitsuhiro Uchida
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Publication number: 20110052779Abstract: The present invention provides a composition for beverage use comprising an acidic soluble protein, and one or two or more powdery or granular salts selected from the group consisting of alkali metal salts of organic acids and water-soluble basic salts, wherein at least the acidic soluble protein is granulated. Furthermore, the present invention provides a process for producing a composition for beverage use containing an acidic soluble protein, comprising: adding to the acidic soluble protein one or two or more powdery or granular salts selected from alkali metal salts of organic acids and water-soluble basic salts in a proportion of 0.01 to 10 parts by weight with respect to 100 parts by weight of the acidic soluble protein, and subjecting at least the acidic soluble protein to granulation. In the composition for beverage use, the formation of undissolved lumps when the composition is dissolved in water is suppressed.Type: ApplicationFiled: August 2, 2010Publication date: March 3, 2011Applicant: MEIJI SEIKA KAISHA, LTD.Inventors: Toshiaki Hirata, Nobutaka Yahiro, Takuya Kodama, Takayasu Fukuyama