Patents Assigned to Meiji Seika Kaisha
  • Transparent acid drink containing acid-soluble casein phosphopeptide
    Patent number: 5405756
    Abstract: A transparent storage stable acidic beverage or other alimentary product containing casein phosphopeptide is obtained by reacting casein with trypsin, precipitating insoluble components at acid pH, adding a divalent cation such as calcium to the reaction medium, recovering the reaction product, and adding the casein phosphopeptide to a mixture to produce a beverage or product having beneficial solubilizing effects on calcium.
    Type: Grant
    Filed: January 5, 1994
    Date of Patent: April 11, 1995
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Hiroshi Naito, Tadashi Noguchi, Ryuichiro Sato, Keiko Tsuji, Hidemasa Hidaka
  • Method for producing azetidinone and cephalosporin derivatives
    Patent number: 5405955
    Abstract: New compounds are disclosed having the general formulas (1) and (2): ##STR1## Also described is a process for preparing the compounds of formulas (1) and (2). Further described is a process for preparing a cephalosporin derivative having formula (5): ##STR2## by converting the compound of formula (1) to the compound of formula (2) and then converting the compound of formula (2) to the compound of formula (5).
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: April 11, 1995
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Osamu Sakanaka, Shouhei Yasuda, Shinjiro Sumi, Katsufumi Sebata, Katsuharu Iinuma, Ken Nishihata
  • Process for the manufacture of chocolate confectionary by entrapping a fatty cream with fine gas bubbles therein
    Patent number: 5370888
    Abstract: A process for the manufacture of chocolate confectionery by entrapping a fatty cream with fine gas bubbles. The confectionery is manufactured by preparing a shell chocolate with open end in a mold, feeding under pressure a fine gas bubble entrapping fatty cream base into the shell chocolate through the opening to fill the shell, scraping off excessively charged fatty cream, solidifying the fatty cream in the shell, pouring a chocolate base on the solidified fatty cream to close the opening of the shell chocolate, scraping off excessively charged chocolate base, solidifying the chocolate base, and demolding the product. A stencil plate can be used, when the gas bubble entrapping fatty cream is charged into the shell of shell chocolate.
    Type: Grant
    Filed: January 19, 1994
    Date of Patent: December 6, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Iwao Hachiya, Tetsuo Koyano, Mitsuo Yamaguchi
  • Method of and apparatus for detecting microorganisms
    Patent number: 5366858
    Abstract: The present invention provides a method of detecting microorganisms, comprising the step of converting physical forms of microorganisms by antigen-antibody reaction and successively measuring the information that shows the physical forms of the converted data, and the step of comparing a statistical pattern of the values thus measured and a reference statistical pattern of a control subjected to no antigen-antibody reaction, thus detecting the microorganisms of interest. A change in both patterns, i.e., no correspondence thereof, enables recognition of the presence of the microorganisms of interest.
    Type: Grant
    Filed: September 18, 1992
    Date of Patent: November 22, 1994
    Assignees: Canon Kabushiki Kaisha, Meiji Seika Kaisha
    Inventors: Naohisa Koizumi, Shokichi Nakajima, Naoki Yuguchi, Kazumi Tanaka
  • Enterobacter cloacae ferm BP1529 having plant growth acceleratory activity
    Patent number: 5360737
    Abstract: A microorganism belonging to the genus Enterobacter and having a plant growth acceleratory activity, particularly Enterobacter cloacae, and a method for cultivating crops using the microorganism or polysaccharides produced therefrom are disclosed.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: November 1, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Takafumi Ishii, Takashi Adachi, Toshio Yasumura, Shinji Miyadoh, Hidemasa Hidaka
  • Gamma-polyglutamate hydrolase
    Patent number: 5356805
    Abstract: An enzyme produced by a microorganism belonging to the genus Myrothecium hydrolyzes .gamma.-polyglutamic acid with an endo action to produce oligoglutamic acid consisting of 2 to 4 glutamic acid residues.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: October 18, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Toshio Tanaka, Makoto Taniguchi, Osamu Hiruta, Kazumichi Uotani
  • Indoleacetic acid synthetase-encoding gene
    Patent number: 5336766
    Abstract: An Enterobacter cloacae-derived gene encoding an enzyme involved in the biosynthetic pathway from tryptophan to indoleacetic acid via indolepyruvic acid and indoleacetaldehyde as intermediates.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: August 9, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Jinichiro Koga, Takashi Adachi, Hidemasa Hidaka
  • 2-piperidinecarboxylic acid derivative, oncogene suppressor and agent for obtaining revertants
    Patent number: 5334723
    Abstract: A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: August 2, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tsuneo Okonogi, Osamu Makabe, Yuichi Yamamoto, Osamu Itoh, Tsutomu Tsuruoka, Takayuki Usui, Seiji Shibahara, Kozo Nagaoka, Shigeharu Inouye, Nobuko Okada, Susumu Nishimura
  • Cephalosporin derivatives
    Patent number: 5332731
    Abstract: A new class of cephalosporin derivatives is provided, which is useful as antibacterial agent to be particularly suitable for oral administrations in mammals including man, and which is represented by general formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom or an ester-forming group capable of being cleaved easily with an esterase existing in the digestive tracts; n is an integer of zero or 1; Z is a saturated heterocyclic group containing one or two oxygen atoms as the hetero-atoms with or without one or more lower alkyl substituents, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: July 26, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yuichi Yamamoto, Tsuneo Okonogi, Seiji Shibahara, Shigeharu Inoue
  • Fructose transferring enzyme absorbed on a granular carrier for production of fructooligosaccharides
    Patent number: 5314810
    Abstract: A fructose transferring enzyme is immobilized by adsorption on a granular carrier having a primary to quaternary amine. The carrier is preferably an epoxy polymer, a vinyl polymer or a chitosan derivative having a primary, secondary or tertiary amine. Immobilization can be performed without or with a crosslinking agent. The immobilized enzyme is used for producing fructooligosaccharides by passing a sucrose solution through a column containing the immobilized enzyme.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: May 24, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Toshiaki Kono, Goichi Yamaguchi, Hidemasa Hidaka
  • Method of inhibiting tumor growth using xanthocillin X dimethylether
    Patent number: 5312833
    Abstract: Tumor growth in a mammal is inhibited by the administration of an effective amount of xanthocillin X dimethylether. The xanthocillin X dimethylether is administered in a range of 10-3,000 milligrams per day for an average adult human patient. The xanthocillin X dimethylether can be administered orally, by direct application into a neoplastic lesion, or by other parenteral forms of administration including intravenous, subcutaneous, or intramuscular injections. Also, suppository forms can be used.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: May 17, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tsutomu Tsuruoka, Harumi Fukuyasu, Katsumi Kawaharajo, Masao Koyama, Hiroshi Kurihara
  • Herbicidal foam composition
    Patent number: 5308827
    Abstract: This invention relates to a herbicidal foam composition comprising, on the basis of the total weight of the composition, (a) a herbicide selected from the group consisting of Bialaphos, Glufosinate, Glyphosate and a mixture thereof, (b) an anionic and/or nonionic surfactant(s), (c) a solvent, (d) a foam controlling agent selected from the group consisting of silicone oil, a C.sub.1 -C.sub.10 alcohol and a mixture thereof, (e) water as a diluent and (f) liquefied petroleum gas as a propellant, the pH of said composition being adjusted to within about 3-11.
    Type: Grant
    Filed: February 24, 1993
    Date of Patent: May 3, 1994
    Assignees: Fumakilla Limited, Meiji Seika Kaisha, Ltd.
    Inventors: Naoki Sakamoto, Osamu Sudo, Tomoko Shomura, Youko Inoue
  • Process for the preparation of a 3-substituted thio-3-cephem compound
    Patent number: 5294705
    Abstract: An ester of 7-acylamido-3-acylthio-3- or -2-cephem-4-carboxylic acid represented by general formula (1) ##STR1## wherein R.sup.1 is an acyl group, R.sup.2 is a carboxyl-protecting group, R.sup.3 is a lower alkyl group, an aryl group or a substituted aryl group, or a mixture of two or more of said ester is used as the starting compound and is reacted wit a tertiary amine and also a secondary amine. Then the tertiary amine salt compound as formed as the reaction product is reacted with a compound of formula (4)R.sup.4 --X (4)wherein R.sup.4 is a lower alkyl group, a cycloalkyl group or a heterocyclic group or a heterocyclic group-substituted methyl group and X is a leaving group, whereby the desired ester of 7-acylamido-3-substituted thio-3-cephem-4-carboxylic acid of formula (5) ##STR2## can be produced preferentially, conveniently and efficiently.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: March 15, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yuichi Yamamoto, Tsuneo Okonogi, Seiji Shibahara, Shigeharu Inoue
  • Benzothiazole and benzimidazole derivatives and antiulcer agent containing the same
    Patent number: 5294629
    Abstract: A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: March 15, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tomoya Machinami, Kazue Yasufuku, Seiji Shibahara, Fumiya Hirano, Yasukatsu Yuda, Motohiro Nishio, Yuji Matsuhashi, Takashi Tsuruoka, Kiyoaki Katano, Shigeharu Inoye
  • Antibacterial and deodorant processing agent and processing method using same
    Patent number: 5268168
    Abstract: An antibacterial and deodorant processing agent for the sanitary processing, in particular, for the sanitary processing of a fiber material having a hydrophobic surface, which comprises a derivative of an aminoglycoside antibiotic, and a method for the antibacterial and deodorant processing of a fiber material having a hydrophobic surface with the use of said antibacterial and deodorant processing agent.
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: December 7, 1993
    Assignees: Sakai Engineering Co., Ltd., Meiji Seika Kaisha, Ltd.
    Inventors: Matsuko Katayama, Kimiaki Yasuda, Hidehi Takebe, Katsuharu Iinuma, Toshio Yoneta
  • Megakaryocyte colony stimulating factor and process for its preparation
    Patent number: 5258324
    Abstract: A novel megakaryocyte colony stimulating factor has been isolated from the supernatant of the culture obtained by cultivating a cell strain of a human large cell lung cancer. When the factor is applied to human or murine bone-marrow cells in vitro, it forms a megakaryocyte colony. Also, the factor increases the number of platelets in peripheral blood in vivo.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: November 2, 1993
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keita Matsunaga, Shinichiro Kuriya, Kiyoyuki Ogata, Hiroyuki Hamaguchi, Chuhei Nojiri, Osamu Makabe, Takeo Nomura, Kozo Nagaoka
  • Disinfectant composition
    Patent number: 5256701
    Abstract: A disinfectant composition comprising an aqueous solution or an alcoholic aqueous solution in a concentration of 83 v/v % or less which contains hydroxypropyl cellulose in a concentration of from 0.5 to 10 w/v %, iodine in a concentration of from 0.01 to 1.0 w/v %, and an iodide in a concentration of not more than 0.5 w/v %. The composition has reduced skin irritation while exhibiting sufficient bactericidal and viricidal activity.
    Type: Grant
    Filed: November 19, 1991
    Date of Patent: October 26, 1993
    Assignees: Zenzo Tamura, Meiji Seika Kaisha Ltd.
    Inventors: Zenzo Tamura, Kuniko Shoji, Chieko Azegami, Takao Kunisada, Kaoru Hosoi, Kiwa Suzuki, Shikifumi Kitazawa
  • Cancer cell metastasis inhibitor methods
    Patent number: 5250545
    Abstract: Sugar lactams such as N-(3-phenylpropyl)-1-deoxynojirimycin, 1-deoxynojirimycin, D-glucaro-.delta.-lactam, 6-O-triphenylmethyl-D-gluco-.delta.-lactam, etc., and new derivatives thereof which inhibit metastasis of cancer cells.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: October 5, 1993
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tsutomu Tsuruoka, Satoru Nakabayashi, Harumi Fukuyasu, Yuuko Ishii, Takashi Tsuruoka, Haruo Yamamoto, Shigeharu Inouye, Shinichi Kondo
  • Process for producing carbonated jelly products
    Patent number: 5244686
    Abstract: A process for producing a carbonated jelly product rich in coolness to the taste is disclosed, comprising adding carbon dioxide to a uniform dispersion of cold water-insoluble .kappa.-carrageenan and/or .iota.-carrageenan in an aqueous solution, sealing the carbonated dispersion into a container, sterilizing the dispersion by heating, and cooling the dispersion to set.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: September 14, 1993
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Takayasu Fukuyama, Kazuo Horii, Kiyoshi Takanoyama
  • Oxamic acid compounds and pharmaceutical composition for use in improvement of damaged cerebral functions of brain
    Patent number: 5232947
    Abstract: New N,N-di-alkyl- or alkenyl-substituted derivatives of oxamic acid of which the two alkyl or alkenyl groups are different from each other are now produced and found to exhibit the cerebral protective effect against cerebral anoxia in the brain of a mammalian animal, including human, and to be useful as an agent for improving or ameliorating the damaged or disturbed functions of the brain. Some known N,N-di-alkyl-substituted derivatives of oxamic acid or which the two alkyl groups are identical to each other are now also found to have similar, cerebral protective effect against cerebral anoxia and to be useful as an agent for improving the damaged functions of the brain.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: August 3, 1993
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yasuo Sato, Shinsuke Katoh, Kunio Atsumi, Mitsugu Hachisu, Seiji Shibahara