Patents Assigned to MeiraGTx UK Il Limited
  • Regulation of Gene Expression by Aptamer-Mediated Accessibility of Polyadenylation Signals
    Publication number: 20240093209
    Abstract: The invention provides polynucleotide constructs for the regulation of gene expression by aptamer-based modulation of the accessibility of one or more polyadenylation signals and methods of using the constructs to regulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The polynucleotide construct contains a riboswitch comprising an aptamer and an effector stem loop, wherein the effector stem loop comprises a polyadenylation signal sequence.
    Type: Application
    Filed: March 3, 2023
    Publication date: March 21, 2024
    Applicant: MeiraGTx UK Il Limited
    Inventors: Xuecui Guo, Joonhee Han, Zhaojing Zhong