Abstract: Catheter systems with multiple inner lumens that converge at the catheter distal tip are preloaded with at least two guidewires. The catheters offers sequential probing with two or more guidewires, therefore improving on procedural speed and accuracy. The catheters comprise proximal and distal regions enabling angled lumens to merge into a common lumen with a diameter slightly larger to the largest of the two proximal lumens. The confluence of the two proximal lumens comprises a single lumen with a reduced profile and cross sectional area. The lumens merge with the larger lumen at an angle greater than zero degrees, and the distal tip has a diameter equal to the diameter of the smaller proximal lumen. The proximal region serves as a directed passageway for different guidewires that enter the catheter through two proximal lumens and which may be reoriented through a convergence region for sequential exiting of the catheter tip.