Patents Assigned to MEMORAL SLOAN KETTERING CANCER CENTER
  • Agents and methods for treating CBP-dependent cancers
    Patent number: 11952405
    Abstract: Single chain peptides comprising either a cell penetrating HIV-TAT peptide sequence and a MYB:CBP complex interfering peptide sequence from MYB, or compsiring a cell penetrating HIV-TAT peptide sequence, a CBP binding peptide sequence from CREB and a MYB:CBP complex interfering peptide sequence from MYB, are provided for use in preventing MYB:CBP complex formation and downstream events leading to cancer, in particular a leukemia. Both L-amino acid single chain peptides and retro-inverso single chain peptides are provided.
    Type: Grant
    Filed: November 29, 2021
    Date of Patent: April 9, 2024
    Assignee: MEMORAL SLOAN KETTERING CANCER CENTER
    Inventors: Alex Kentsis, Kavitha Ramaswamy, Lauren Marek