Patents Assigned to Mercator Genetics, Inc.
  • Hereditary hemochromatosis gene
    Patent number: 6025130
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: February 15, 2000
    Assignee: Mercator Genetics, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Megabase transcript map: novel sequences and antibodies thereto
    Patent number: 5872237
    Abstract: A fine structure map of the 1 megabase region surrounding the candidate HH gene is provided, along with 250 KB of DNA sequence and 8 loci corresponding to candidate genes within the 1 megabase region. These loci are useful as genetic markers for further mapping studies. Additionally, the eight cDNA sequences corresponding to those loci are useful, for example, for the isolation of other genes in putative gene families, and as probes for diagnostic assays. Additionally, the proteins encoded by those cDNAs are useful in the generation of antibodies for analysis of gene expression and in diagnostic assays, and in the purification of related proteins.
    Type: Grant
    Filed: October 1, 1996
    Date of Patent: February 16, 1999
    Assignee: Mercator Genetics, Inc.
    Inventors: John Nathan Feder, Gregory Scott Kronmal, Peter M. Lauer, David A. Ruddy, Winston Thomas, Zenta Tsuchihashi, Roger K. Wolff
  • Method to diagnose hereditary hemochromatosis
    Patent number: 5753438
    Abstract: New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: May 19, 1998
    Assignee: Mercator Genetics, Inc.
    Inventors: Dennis T. Drayna, John N. Feder, Andreas Gnirke, Bruce E. Kimmel, Winston J. Thomas, Roger K. Wolff
  • Method to diagnose hereditary hemochromatosis
    Patent number: 5705343
    Abstract: New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: January 6, 1998
    Assignee: Mercator Genetics, Inc.
    Inventors: Dennis T. Drayna, John N. Feder, Andreas Gnirke, Bruce E. Kimmel, Winston J. Thomas, Roger K. Wolff
  • Efficient method to conduct large-scale genome sequencing
    Patent number: 5670321
    Abstract: An efficient method for sequencing large fragments of DNA is described. A subclone path through the fragment is first identified; the collection of subclones that define this path is then sequenced using transposon-mediated direct sequencing techniques to an extent sufficient to provide the complete sequence of the fragment.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: September 23, 1997
    Assignee: Mercator Genetics, Inc.
    Inventors: Bruce E. Kimmel, Michael Ellis, David Ruddy