Abstract: Compounds, such as cathinone derivatives, and pharmaceutical formulations that include the compounds. The compounds may have a first selectivity for a first receptor subtype that is at least 10 times greater than a second selectivity for a second receptor subtype from the same class of receptors. Methods of treating patients, which may include administering to a patient a pharmaceutical formulation that includes a compound, such as a cathinone derivative.

Abstract: This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

Abstract: This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure relates to compounds of the following formula: or salts, esters or prodrugs thereof as described herein.

Abstract: Provided are alternative splicing constructs and methods for their use. In particular, CD44 based alternative splicing constructs are provided that include CD44 exon 5. These alternative splicing constructs are useful in high-throughput assays for testing the effects of compounds on splicing and for achieving targeted cell death.

Abstract: Inhalation airflow regulation devices and inhalers are disclosed. Methods of making and using inhalation airflow regulation devices are also disclosed.

Abstract: Prosthetic devices containing an artificial foot are disclosed. Methods of making and using prosthetic devices containing an artificial foot are also disclosed. The artificial foot may be in the form of a thermoformed foot member having at least one foot member curved section between a foot member first end and a foot member second end opposite the foot member first end such that (a) a first portion of a foot member inner surface overlaps and faces a second portion of the foot member inner surface, (b) a foot member second end surface is positioned (i) between and connecting a foot member outer surface and the foot member inner surface to one another and (ii) over and facing the foot member second end surface along the at least one foot member curved section.

Abstract: Embodiments provide for health related inquires, such as inquiries for information about a drug, disease, or other condition, to be received and responses to the inquiries to be delivered to the requester. The inquiries may be submitted electronically and the response may likewise be returned electronically. It may be determined whether the requester is a healthcare provider or a patient and the formulation of the response proceeds based on which type of requester submitted the inquiry. Delivery characteristics may be specified for the inquiry such as the delivery type and a timeframe for delivery. An account may be provided for requesters to provide information including a default delivery type and credentials to establish the requester type. Additional features may be provided including newsfeed subscriptions related to the inquiry to provide ongoing information subsequent to the submission of the inquiry.

Abstract: Compositions containing a reaction product of gellan gum and polyethylene glycol are disclosed. Methods of making controlled-release gellan gum nanoparticles and methods of using controlled-release gellan gum nanoparticles are also disclosed.

Abstract: Symmetrical differential capacitive sensors are disclosed. Methods of making and using symmetrical differential capacitive sensors are also disclosed.

Abstract: A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable oil, mineral oil and/or a lower alcohol such that the formed microspheres demonstrate intracellular bioactivity when taken up by macrophages.

Abstract: Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system microencapsulated with a biodegradable nonantigenic material, such as albumin or PLGA. When the composition is introduced into a subject, it is phagocytosed by the target organ, the target organ digests the microsphere, releasing the drug or an active form or fragment thereof intracellularly. The drug then modifies the target organ function, thereby modulating it's activity. A method is disclosed for preparation of the microencapsulated composition.

Abstract: Pharmaceutically acceptable compounds for administering to a subject, comprising the general structure II: wherein R1 is an L-amino acid or salt or ester thereof, or an L-amino acid containing peptide or salt or ester thereof; and wherein the stereochemistry about the carbon-carbon double bond is trans. The invention further relates to pharmaceutical compositions comprising the aforementioned compounds.

Abstract: A system for locating electromagnetic signal sources via the rotational Doppler effect whereby a radar station generating electromagnetic signals, such as radar frequency signals, initially scans the sky for aircraft. An aircraft having the system operationally installed thereon and utilizing apparatus or navigational systems already present on the aircraft receives radar signals. The system is programmed to capture radar signal parameters and extract the rotational Doppler frequencies induced by the motion of the aircraft. The angular velocity of the host platform is often the dominant source of this frequency; however, lateral velocity is not detrimental to the process. The measurement of the rotational Doppler frequency is accomplished through antennas presently installed on large numbers of military aircraft with no requirement for phase calibration of the electrical paths between antennas and receiver.

Abstract: Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system microencapsulated with a biodegradable nonantigenic material, such as albumin or PLGA. When the composition is introduced into a subject, it is phagocytosed by the target organ, the target organ digests the microsphere, releasing the drug or an active form or fragment thereof intracellularly. The drug then modifies the target organ function, thereby modulating it's activity. A method is disclosed for preparation of the microencapsulated composition.

Abstract: The invention relates to a method for reducing inflammation in a subject by administering to the subject an effective amount of the compound having the structure I or II: wherein, R1 is C1-C10 branched or straight chain alkyl, aryl, an amino acid, or a peptide; and R2 is hydrogen or lower C1-C5 branched or straight alkyl, or the salt or ester thereof, wherein the stereochemistry about the carbon-carbon double bond is trans. The invention further relates to a method of inducing an analgesic effect by administering to a subject an effective amount of the compound having the structure I or II. The invention further relates to a compound having the structure II, wherein, R1 is an N-acyl amino acid or peptide, or the salt or ester thereof.

Abstract: A system and method for cleaning or removing coatings, such as paint, from a surface with a stream of particles. A carbon dioxide (CO.sub.2) pelletizer forms carbon dioxide pellets, which are delivered by a delivery system against a surface to be cleaned. The delivery system includes a hopper for containing the pellets and a high pressure air supply. A feeder introduces the pellets from the hopper into the high pressure air. The combined high pressure air and pellets are directed along a delivery hose to a nozzle, which directs the air and pellets against a surface to be cleaned. Temperature sensors are provided to monitor the temperature of the pressurized air at various points in the delivery system. Signals from the temperature sensor are provided in a feedback control manner to a control valve. The control valve controls the introduction of liquid nitrogen (N.sub.2) into the air stream at a mixing chamber in the delivery system.