Patents Assigned to Merck
  • Publication number: 20250145833
    Abstract: Metal effect pigments, having a surface treatment comprising A) phosphoric acid (H3PO4), B) tetraethyl orthosilicate (TEOS) and C) at least one organic coupling agent to the metal effect pigments, exhibiting excellent humidity resistance performance without any influence on the chroma, luster and color of base metal effect pigments, a process for producing same and their use.
    Type: Application
    Filed: February 6, 2023
    Publication date: May 8, 2025
    Applicant: MERCK PATENT GmbH
    Inventor: Bangyin LI
  • Patent number: 12291538
    Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: May 6, 2025
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Indu Bharathan, Symon Gathiaka, Yongxin Han, Xiaoshen Ma, Ryan D. Otte, David L. Sloman, Thomas H. Graham, Timothy Henderson, Elisabeth Hennessy, Anandan Palani
  • Patent number: 12291570
    Abstract: A method of treating metastatic pancreatic adenocarcinoma in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of each of a peptide set forth in SEQ ID NO: 1, an anti PD-1 and a chemotherapy, thereby treating the metastatic pancreatic adenocarcinoma.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: May 6, 2025
    Assignees: BioLineRx Ltd., Merck Sharp & Dohme Corp.
    Inventors: Abi Vainstein-Haras, Ella Sorani, Irit Gliko-Kabir, Osnat Bohana-Kashtan, Amnon Peled
  • Publication number: 20250142980
    Abstract: A layer, sheet or film containing one or more flake-form effect pigments and one or more light scattering centers, methods for its preparation, its use for any type of device collecting solar cell energy, including but not limited to coloring solar cells or solar cell modules, and devices collecting solar cell energy, including but not limited to colored solar cells or colored solar cell modules, comprising such a layer, sheet or film, and methods for their preparation.
    Type: Application
    Filed: August 9, 2022
    Publication date: May 1, 2025
    Applicant: Merck Patent GmbH
    Inventors: Sebastian BARTH, Laurent DELOUX, Marc HUNGER, Zhen WENG, Claudio BRIGHINA, Jan-Niclas KONZ
  • Publication number: 20250136910
    Abstract: In some embodiments, devices for use as blood-brain barrier models are disclosed. The devices may include either a hydrogel component that surrounds a channel formed between a first opening and a second opening of the hydrogel component, or a hydrogel component that forms a groove. The devices may further include pericytes disposed in the channel or the groove, and endothelial cells may be disposed in the channel or the groove. The hydrogel component may include astrocytes (e.g., printed into the hydrogel component via projection stereolithography). Also disclosed are various methods of making and using these devices.
    Type: Application
    Filed: October 16, 2024
    Publication date: May 1, 2025
    Applicants: Merck Sharp & Dohme LLC, William Marsh Rice University
    Inventors: Nicole L. Buist, Martha J. Fowler, Yufang He, Anna Kristen Mai, Adam T. Procopio, Madison K. Royse, Omid Veiseh, Jun Xu
  • Publication number: 20250136868
    Abstract: Liquid-crystalline (LC) media or LC materials and energy saving liquid-crystal displays (LCDs) containing these media, especially gaming displays and AR/VR headsets addressed by an active matrix and in particular to LC displays of the TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, HB-FFS, XB-FFS, PS-FFS, SA-HB-FFS, SA-XB-FFS, polymer stabilised SA-HB-FFS, polymer stabilised SA-XB-FFS, positive VA or positive PS-VA type.
    Type: Application
    Filed: August 29, 2024
    Publication date: May 1, 2025
    Applicant: Merck Patent GmbH
    Inventors: Sven Christian Laut, Hee-Kyu Lee, Jing Wang
  • Patent number: 12286503
    Abstract: The disclosed subject matter relates compounds of structure (I), and polymers of structure (II) having a polydispersity ranging from 1 to about 1.1, compositions comprising said polymers and a spin casting solvent, the process of forming a pinning layer selectively on metal with said composition and the process of using said pinning layers to affect chemoepitaxy directed self-assembly of an overlying block copolymer, and the subsequent process of pattern transfer of this self-assembled layer into a substrate by etching.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: April 29, 2025
    Assignee: Merck Patent GmbH
    Inventors: EunJeong Jeong, Durairaj Baskaran, Jihoon Kim
  • Patent number: 12286449
    Abstract: Metal complexes including cyclopentadienyl ligands and methods of using such metal complexes to prepare metal-containing films are provided.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: April 29, 2025
    Assignee: MERCK PATENT GMBH
    Inventors: Ming Fang, Joby Eldo, Charles Dezelah, Daniel Moser, Ravi Kanjolia
  • Publication number: 20250127938
    Abstract: The present disclosure relates to new folate-conjugates comprising a 5-methyltetrahydro-folate, a radiometal chelator optionally coordinating a radiometal M, and the albumin binder 5-(p-iodophenyl)pentanoate, and further provides uses of such conjugates and/or pharmaceutical compositions thereof in diagnostic imaging, radionuclide therapy or theragnostic applications.
    Type: Application
    Filed: January 30, 2023
    Publication date: April 24, 2025
    Applicant: Merck Patent GmbH
    Inventors: Viola GROEHN, Marie-Luise RENZ, Rudolf MOSER, Roger SCHIBLI, Cristina Magdalena MUELLER, Luisa Maria DEBERLE, Anna Elisabeth BECKER, Sara Dorina BUSSLINGER
  • Publication number: 20250128216
    Abstract: A stirring device for stirring a biphasic fluid has a stirring shaft that can be mounted with a mounting end into a stirring drive. The stirring device also has a first paddle that is arranged in a rotationally fixed manner at or near a stirring end of the stirring shaft that is opposite to the mounting end, and further has a second paddle that is arranged in a rotationally fixed manner at the stirring shaft in between the mounting end and the first paddle. The second paddle is mounted with respect to the stirring shaft in such a manner that it can be displaced in an axial direction along the stirring shaft, which allows for a change of an axial distance between the second paddle and the mounting end of the stirring shaft.
    Type: Application
    Filed: September 22, 2022
    Publication date: April 24, 2025
    Applicant: Merck Patent GmbH
    Inventors: Christian Jede, Kirstin Meiners, Marcel Wedel, Malte Bogdahn
  • Publication number: 20250129183
    Abstract: The present invention relates to immunoglobulins that specifically bind MMP13 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit an activity of MMP13 and preferably are also stable.
    Type: Application
    Filed: September 23, 2024
    Publication date: April 24, 2025
    Applicants: Merck Patent GmbH, ABLYNX NV
    Inventors: Francis DESCAMPS, Gerald BESTE, Guy HERMANS, Hans GUEHRING, Lars TOLEIKIS, Christoph LADEL
  • Publication number: 20250127879
    Abstract: Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 (“PD-1”) or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.
    Type: Application
    Filed: June 7, 2024
    Publication date: April 24, 2025
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, MEMORIAL SLOAN KETTERING CANCER CENTER, MERCK SHARP & DOHME LLC
    Inventors: Peter PALESE, Adolfo GARCIA-SASTRE, Dmitriy ZAMARIN, Svetlana SADEKOVA, Rachel Allison ALTURA, Uyen PHAN, Brian B. HAINES, Jedd D. WOLCHOK
  • Patent number: 12280107
    Abstract: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol.
    Type: Grant
    Filed: February 15, 2023
    Date of Patent: April 22, 2025
    Assignee: Merck Sharp & Dohme LLC
    Inventors: William J. Smith, Cecilia Giovarelli, Denise K. Nawrocki
  • Patent number: 12281109
    Abstract: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing cancer, inflammation, neurodegeneration disease and/or diabetes in a subject.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: April 22, 2025
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Jian Liu, Younong Yu, Joseph A. Kozlowski, Deyou Sha, Wensheng Yu, Joseph M. Kelly, Scott E. Wolkenberg
  • Publication number: 20250122282
    Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.
    Type: Application
    Filed: August 13, 2021
    Publication date: April 17, 2025
    Applicant: Merck Patent GmbH
    Inventors: Jan Anderl, Sabine Raab-Westphal, Stefan Hecht, Carl Deutsch, Min Shan, Doreen Könning, Willem N. Sloot, Felix Hart, Christian Schröter, Lars Toleikis, Nir Berger
  • Patent number: 12275800
    Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: April 15, 2025
    Assignees: Merck Sharp & Dohme LLC, Adimab, LLC
    Inventors: Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Bianka Prinz, Vaishnavi Ganti, Mohammad Tabrizifard
  • Patent number: 12275682
    Abstract: The present application relates to materials for use in electronic devices, to processes for preparing the materials, and to electronic devices containing the materials.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: April 15, 2025
    Assignee: MERCK PATENT GMBH
    Inventors: Elvira Montenegro, Teresa Mujica-Fernaud, Florian Maier-Flaig, Frank Voges
  • Patent number: 12275729
    Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: April 15, 2025
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Yongqi Deng, Abdelghani Achab, David Jonathan Bennett, Indu Bharathan, Xavier Fradera, Craig Gibeau, Yongxin Han, Derun Li, Kun Liu, Qinglin Pu, Sulagna Sanyal, David Sloman, Wensheng Yu, Hongjun Zhang
  • Patent number: 12279521
    Abstract: The invention relates to fluorene derivatives and electronic devices, particularly organic electroluminescent devices in which said compounds are used, particularly as a matrix material for phosphorescent emitters.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: April 15, 2025
    Assignee: Merck Patent GmbH
    Inventors: Nils Koenen, Anna Hayer, Florian Maier-Flaig, Jochen Pfister, Holger Heil
  • Patent number: 12276909
    Abstract: The present invention relates to resist compositions comprising a polymer component, a photoacid generator component (PAG), a photoactive diazonaphthoquinone component (PAC), a base component, a solvent component, and optionally, a heterocyclic thiol component. The polymer component is a Novolak derivative, comprising Novolak repeat units with free phenolic hydroxy moieties, and Novolak repeat units comprising phenolic hydroxy moieties protected with an acid cleavable acetal moiety.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: April 15, 2025
    Assignee: Merck Patent GmbH
    Inventors: Medhat A. Toukhy, Weihong Liu, Takanori Kudo, Hung-Yang Chen, Jian Yin