Patents Assigned to Merck
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Publication number: 20250145833Abstract: Metal effect pigments, having a surface treatment comprising A) phosphoric acid (H3PO4), B) tetraethyl orthosilicate (TEOS) and C) at least one organic coupling agent to the metal effect pigments, exhibiting excellent humidity resistance performance without any influence on the chroma, luster and color of base metal effect pigments, a process for producing same and their use.Type: ApplicationFiled: February 6, 2023Publication date: May 8, 2025Applicant: MERCK PATENT GmbHInventor: Bangyin LI
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Patent number: 12291538Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.Type: GrantFiled: May 3, 2023Date of Patent: May 6, 2025Assignee: Merck Sharp & Dohme LLCInventors: Indu Bharathan, Symon Gathiaka, Yongxin Han, Xiaoshen Ma, Ryan D. Otte, David L. Sloman, Thomas H. Graham, Timothy Henderson, Elisabeth Hennessy, Anandan Palani
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Patent number: 12291570Abstract: A method of treating metastatic pancreatic adenocarcinoma in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of each of a peptide set forth in SEQ ID NO: 1, an anti PD-1 and a chemotherapy, thereby treating the metastatic pancreatic adenocarcinoma.Type: GrantFiled: October 17, 2019Date of Patent: May 6, 2025Assignees: BioLineRx Ltd., Merck Sharp & Dohme Corp.Inventors: Abi Vainstein-Haras, Ella Sorani, Irit Gliko-Kabir, Osnat Bohana-Kashtan, Amnon Peled
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Publication number: 20250142980Abstract: A layer, sheet or film containing one or more flake-form effect pigments and one or more light scattering centers, methods for its preparation, its use for any type of device collecting solar cell energy, including but not limited to coloring solar cells or solar cell modules, and devices collecting solar cell energy, including but not limited to colored solar cells or colored solar cell modules, comprising such a layer, sheet or film, and methods for their preparation.Type: ApplicationFiled: August 9, 2022Publication date: May 1, 2025Applicant: Merck Patent GmbHInventors: Sebastian BARTH, Laurent DELOUX, Marc HUNGER, Zhen WENG, Claudio BRIGHINA, Jan-Niclas KONZ
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Publication number: 20250136910Abstract: In some embodiments, devices for use as blood-brain barrier models are disclosed. The devices may include either a hydrogel component that surrounds a channel formed between a first opening and a second opening of the hydrogel component, or a hydrogel component that forms a groove. The devices may further include pericytes disposed in the channel or the groove, and endothelial cells may be disposed in the channel or the groove. The hydrogel component may include astrocytes (e.g., printed into the hydrogel component via projection stereolithography). Also disclosed are various methods of making and using these devices.Type: ApplicationFiled: October 16, 2024Publication date: May 1, 2025Applicants: Merck Sharp & Dohme LLC, William Marsh Rice UniversityInventors: Nicole L. Buist, Martha J. Fowler, Yufang He, Anna Kristen Mai, Adam T. Procopio, Madison K. Royse, Omid Veiseh, Jun Xu
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Publication number: 20250136868Abstract: Liquid-crystalline (LC) media or LC materials and energy saving liquid-crystal displays (LCDs) containing these media, especially gaming displays and AR/VR headsets addressed by an active matrix and in particular to LC displays of the TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, HB-FFS, XB-FFS, PS-FFS, SA-HB-FFS, SA-XB-FFS, polymer stabilised SA-HB-FFS, polymer stabilised SA-XB-FFS, positive VA or positive PS-VA type.Type: ApplicationFiled: August 29, 2024Publication date: May 1, 2025Applicant: Merck Patent GmbHInventors: Sven Christian Laut, Hee-Kyu Lee, Jing Wang
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Patent number: 12286503Abstract: The disclosed subject matter relates compounds of structure (I), and polymers of structure (II) having a polydispersity ranging from 1 to about 1.1, compositions comprising said polymers and a spin casting solvent, the process of forming a pinning layer selectively on metal with said composition and the process of using said pinning layers to affect chemoepitaxy directed self-assembly of an overlying block copolymer, and the subsequent process of pattern transfer of this self-assembled layer into a substrate by etching.Type: GrantFiled: October 18, 2021Date of Patent: April 29, 2025Assignee: Merck Patent GmbHInventors: EunJeong Jeong, Durairaj Baskaran, Jihoon Kim
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Patent number: 12286449Abstract: Metal complexes including cyclopentadienyl ligands and methods of using such metal complexes to prepare metal-containing films are provided.Type: GrantFiled: March 11, 2022Date of Patent: April 29, 2025Assignee: MERCK PATENT GMBHInventors: Ming Fang, Joby Eldo, Charles Dezelah, Daniel Moser, Ravi Kanjolia
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Publication number: 20250127938Abstract: The present disclosure relates to new folate-conjugates comprising a 5-methyltetrahydro-folate, a radiometal chelator optionally coordinating a radiometal M, and the albumin binder 5-(p-iodophenyl)pentanoate, and further provides uses of such conjugates and/or pharmaceutical compositions thereof in diagnostic imaging, radionuclide therapy or theragnostic applications.Type: ApplicationFiled: January 30, 2023Publication date: April 24, 2025Applicant: Merck Patent GmbHInventors: Viola GROEHN, Marie-Luise RENZ, Rudolf MOSER, Roger SCHIBLI, Cristina Magdalena MUELLER, Luisa Maria DEBERLE, Anna Elisabeth BECKER, Sara Dorina BUSSLINGER
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Publication number: 20250128216Abstract: A stirring device for stirring a biphasic fluid has a stirring shaft that can be mounted with a mounting end into a stirring drive. The stirring device also has a first paddle that is arranged in a rotationally fixed manner at or near a stirring end of the stirring shaft that is opposite to the mounting end, and further has a second paddle that is arranged in a rotationally fixed manner at the stirring shaft in between the mounting end and the first paddle. The second paddle is mounted with respect to the stirring shaft in such a manner that it can be displaced in an axial direction along the stirring shaft, which allows for a change of an axial distance between the second paddle and the mounting end of the stirring shaft.Type: ApplicationFiled: September 22, 2022Publication date: April 24, 2025Applicant: Merck Patent GmbHInventors: Christian Jede, Kirstin Meiners, Marcel Wedel, Malte Bogdahn
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Publication number: 20250129183Abstract: The present invention relates to immunoglobulins that specifically bind MMP13 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit an activity of MMP13 and preferably are also stable.Type: ApplicationFiled: September 23, 2024Publication date: April 24, 2025Applicants: Merck Patent GmbH, ABLYNX NVInventors: Francis DESCAMPS, Gerald BESTE, Guy HERMANS, Hans GUEHRING, Lars TOLEIKIS, Christoph LADEL
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Publication number: 20250127879Abstract: Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 (“PD-1”) or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.Type: ApplicationFiled: June 7, 2024Publication date: April 24, 2025Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, MEMORIAL SLOAN KETTERING CANCER CENTER, MERCK SHARP & DOHME LLCInventors: Peter PALESE, Adolfo GARCIA-SASTRE, Dmitriy ZAMARIN, Svetlana SADEKOVA, Rachel Allison ALTURA, Uyen PHAN, Brian B. HAINES, Jedd D. WOLCHOK
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Patent number: 12280107Abstract: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol.Type: GrantFiled: February 15, 2023Date of Patent: April 22, 2025Assignee: Merck Sharp & Dohme LLCInventors: William J. Smith, Cecilia Giovarelli, Denise K. Nawrocki
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Patent number: 12281109Abstract: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing cancer, inflammation, neurodegeneration disease and/or diabetes in a subject.Type: GrantFiled: March 30, 2020Date of Patent: April 22, 2025Assignee: Merck Sharp & Dohme LLCInventors: Jian Liu, Younong Yu, Joseph A. Kozlowski, Deyou Sha, Wensheng Yu, Joseph M. Kelly, Scott E. Wolkenberg
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Publication number: 20250122282Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.Type: ApplicationFiled: August 13, 2021Publication date: April 17, 2025Applicant: Merck Patent GmbHInventors: Jan Anderl, Sabine Raab-Westphal, Stefan Hecht, Carl Deutsch, Min Shan, Doreen Könning, Willem N. Sloot, Felix Hart, Christian Schröter, Lars Toleikis, Nir Berger
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Patent number: 12275800Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.Type: GrantFiled: April 18, 2023Date of Patent: April 15, 2025Assignees: Merck Sharp & Dohme LLC, Adimab, LLCInventors: Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Bianka Prinz, Vaishnavi Ganti, Mohammad Tabrizifard
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Patent number: 12275682Abstract: The present application relates to materials for use in electronic devices, to processes for preparing the materials, and to electronic devices containing the materials.Type: GrantFiled: December 17, 2019Date of Patent: April 15, 2025Assignee: MERCK PATENT GMBHInventors: Elvira Montenegro, Teresa Mujica-Fernaud, Florian Maier-Flaig, Frank Voges
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Patent number: 12275729Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.Type: GrantFiled: October 29, 2018Date of Patent: April 15, 2025Assignee: Merck Sharp & Dohme LLCInventors: Yongqi Deng, Abdelghani Achab, David Jonathan Bennett, Indu Bharathan, Xavier Fradera, Craig Gibeau, Yongxin Han, Derun Li, Kun Liu, Qinglin Pu, Sulagna Sanyal, David Sloman, Wensheng Yu, Hongjun Zhang
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Patent number: 12279521Abstract: The invention relates to fluorene derivatives and electronic devices, particularly organic electroluminescent devices in which said compounds are used, particularly as a matrix material for phosphorescent emitters.Type: GrantFiled: January 15, 2020Date of Patent: April 15, 2025Assignee: Merck Patent GmbHInventors: Nils Koenen, Anna Hayer, Florian Maier-Flaig, Jochen Pfister, Holger Heil
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Patent number: 12276909Abstract: The present invention relates to resist compositions comprising a polymer component, a photoacid generator component (PAG), a photoactive diazonaphthoquinone component (PAC), a base component, a solvent component, and optionally, a heterocyclic thiol component. The polymer component is a Novolak derivative, comprising Novolak repeat units with free phenolic hydroxy moieties, and Novolak repeat units comprising phenolic hydroxy moieties protected with an acid cleavable acetal moiety.Type: GrantFiled: May 22, 2019Date of Patent: April 15, 2025Assignee: Merck Patent GmbHInventors: Medhat A. Toukhy, Weihong Liu, Takanori Kudo, Hung-Yang Chen, Jian Yin