Patents Assigned to Merck and Co., Inc.
  • Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
    Patent number: 5374638
    Abstract: Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: December 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Daljit S. Dhanoa, Kenneth J. Fitch, Daniel F. Veber, Thomas F. Walsh, David L. Williams, Jr.
  • Bridged carbapenem antibacterial compounds
    Patent number: 5374630
    Abstract: Carbapenems of the formula ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: December 20, 1994
    Assignee: Merck & Co., Inc.
    Inventor: Frank P. DiNinno
  • Process for preparing low-fat fried food
    Patent number: 5372829
    Abstract: The present invention is a procedure for preparing cooked foods which involve the use of a gellan gum batter to coat a food substrate to impart qualities which are typically associated with fried foods, including crispness and juiciness. The coated food is then fried and frozen. Food products resulting from the procedure of the present invention contain low levels of fat and yet have the desirable qualities of fried foods.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: December 13, 1994
    Assignee: Merck & Co., Inc.
    Inventors: William F. Chalupa, George R. Sanderson
  • Bridged carbapenem compounds, compositions containing such compounds and methods of use
    Patent number: 5372993
    Abstract: Carbapenems of the formula ##STR1## are useful antibacterial agents. Compositions containing such compounds and methods of use are also disclosed.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: December 13, 1994
    Assignee: Merck & Co., Inc.
    Inventor: Frank P. DiNinno
  • Protein-dimeric polysaccharide conjugate vaccine
    Patent number: 5371197
    Abstract: A conjugate immunogen, having polysaccharide moieties derived from bacterial sources, provides a multivalent vaccine with a low protein to polysaccharide ratio. The vaccine reduces complications associated with injection of protein immunogens due to pyrogenic responses, such as swelling and pain, and is particularly suitable for administration to infants.
    Type: Grant
    Filed: September 24, 1991
    Date of Patent: December 6, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Stephen Marburg, Richard L. Tolman
  • Lipopeptide derivatives
    Patent number: 5369093
    Abstract: The present invention is directed to water-soluble derivatives of antibiotic lipopeptides having the formula. ##STR1## wherein R is H or OH and R' is a phosphono, sulfo or acyl radical possessing a charged group at neutral pH.The derivatives are esters but having a charged group, have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.
    Type: Grant
    Filed: March 15, 1991
    Date of Patent: November 29, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, James M. Balkovec, David J. Mathre
  • Sustained release tablets containing alginate
    Patent number: 5368862
    Abstract: Sustained release tablet comprising a microbially produced alginate-type polysaccharide and an active ingredient to be delivered in controlled fashion.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: November 29, 1994
    Assignee: Merck & Co., Inc.
    Inventor: George Colegrove
  • Cholesterol-lowering agents
    Patent number: 5369125
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: November 29, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Gregory D. Berger, James D. Bergstrom, Tesfaye Biftu, Robert L. Bugianesi, Robert M. Burk, Narindar N. Girotra, C. H. Kuo, William H. Parsons, Mitree M. Ponpipom, Lori L. Whiting
  • Antibiotic agent
    Patent number: 5366880
    Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: November 22, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Prakash S. Masurekar, David F. Sesin, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
  • Controlled release drug dispersion delivery device
    Patent number: 5366738
    Abstract: A device for the controlled delivery of a beneficial agent as a gelatinous dispersion consisting of (i) a core which contains a beneficial agent, a polymer which forms gelatinous microscopic particles upon hydration and if desired an agent to modulate the hydration of the polymer; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of a dispersion comprising gelatinous microscopic particles.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: November 22, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Gerald S. Rork, James D. Pipkin
  • Method of hydroxylating 3-[3-(5-ethyl-2-methoxy-6-methylpyridyl)methyl]amino-5-ethyl-6-methyl-2( 1H)-pyridinone with liver slices
    Patent number: 5364776
    Abstract: Incubation of ##STR1## with a preparation from mammalian organ yields as biotransformation products the 5-(1-hydroxy)ethyl pyridinone analog as well as the 5-(1-hydroxy)ethyl pyridyl and the 5-(2-hydroxy)ethyl pyridyl derivatives.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: November 15, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Suresh K. Balani, Laura R. Kauffman, Anthony D. Theoharides
  • Biologically active compounds isolated from aerobic fermentation of Trichoderma viride
    Patent number: 5364948
    Abstract: This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: November 15, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Guy H. Harris, Deborah Zink, E. Tracy T. Jones, Yu L. Kong
  • Substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
    Patent number: 5364848
    Abstract: New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: November 15, 1994
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Raymond A. Firestone, Paul E. Finke, William K. Hagmann, Shrenik K. Shah, Kevan R. Thompson
  • Single use fluid dispensing device
    Patent number: 5361947
    Abstract: A flexible fluid dispensing bottle is provided which conveniently meters out its contents in several small controlled doses. The device is designed to specifically provide multiple extended outlets to facilitate access beneath the fur of an animal ("comb effect") and to better spread treatment. In addition, the device uses a combination of bottle geometry, and internal ribs and cores to control capacity as well as volume displaced during individual pump strokes of the squeeze bottle.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventor: Arthur L. Lifshey
  • Process for 4"-EPI-acetylamino-4"-deoxy-5-oximinoavermectin-B.sub.1
    Patent number: 5362862
    Abstract: An improved process for formation of a 5-oxime on avermectin derivatives comprises the treatment of the oxo compound with O-(trimethylsilyl)hydroxylamine in the presence of a Lewis acid.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Raymond Cvetovich
  • 2-(heterocyclylheteroaryliumalkyl) phenyl carbapenem antibacterial agents
    Patent number: 5362723
    Abstract: Carbapenems having the formula: ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. DiNinno, Thomas N. Salzmann, David A. Muthard
  • Carrier fluid for the suspension and delivery of water soluble polymers
    Patent number: 5362312
    Abstract: A liquid carrier fluid that is used as a carrier system to suspend and deliver water soluble polymers which act to adjust the rheological properties of the aqueous systems to which they are added.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Bryan Skaggs, Mike O'Brien, James M. Seheult, John M. Swazey
  • Chemical compounds
    Patent number: 5362752
    Abstract: New cholesterol lowering compounds are formed from the photochemical treatment of zaragozic acid A.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Gregory D. Berger, Leeyuan Huang, John G. MacConnell
  • Process for the preparation of 4"-amino avermectin compounds
    Patent number: 5362863
    Abstract: A 4"-oxoavermectin intermediate is reductively aminated using hexa- or heptamethyldisilazane and sodium borohydride to produce a 4"-amino (or methylamino)avermectin. The 4"- aminoavermectin is a useful intermediate in the preparation of N-acyl derivatives. The compounds are useful as agricultural and animal health insecticides and parasiticides.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventor: Raymond Cvetovich
  • Farnesyl pyrophosphate analogs
    Patent number: 5362906
    Abstract: The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, Ta-Jyh Lee, Robert L. Smith, Gerald E. Stokker