Patents Assigned to Merck & Co. Inc., Inc.
  • Derivatives of 3-hydroxyazabenzo(beta)thiophene useful as 5-lipoxygenase inhibitors
    Patent number: 5006532
    Abstract: 3-Hydroxyazabenzo[b]thiophene derivatives having optionally 2-aryl, 2-aralkyl, 2-alkyl or 2-alkenyl substituents were prepared by, among other methods, ring closure of an appropriately substituted benzylthio-alkoxycarbonyl-pyridine. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases such as psoriasis and atopic eczema, cardiovascular disorders, inflammatory diseases and other leukotriene mediated diseases.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: April 9, 1991
    Assignee: Merck & Co. Inc., Inc.
    Inventors: Robert K. Baker, Arsenio A. Pessolano, Kathleen M. Rupprecht, Philippe L. Durette