Abstract: The present invention relates to crystalline forms of O-desmethyl venlafaxine (ODV) succinate monohydrate, namely Forms I and II, in pure form and to novel processes for their preparation. The present invention provides a process for the preparation of Form II free of Form I and a process for the preparation of Form I free of Form II. The present invention provides direct methods for the preparation of ODV succinate Form II from ODV free base and for the preparation of ODV succinate Form I from ODV free base.
Type:
Application
Filed:
October 18, 2007
Publication date:
March 11, 2010
Applicant:
Merck Development Centre Private Limited
Inventors:
Vinayak G. Gore, Vikas S. Kulkarni, V.S. Wakchaure, M.G. Hublikar, S.R. Wavhal
Abstract: The present invention relates to a novel process for the preparation of ?-amino acids, such as (±)-3-(aminomethyl)-5-methyl-hexanoic acid 1, which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid 2.
Type:
Application
Filed:
July 12, 2007
Publication date:
November 19, 2009
Applicants:
Generics [UK] Limited, Merck Development Centre Private Limited
Inventors:
Abhay Gaitonde, Chitra Valdya, P. Khairnar