Patents Assigned to Merck Frosst Canada, Inc.
  • 6-Bromocholesterol derivatives
    Patent number: 4430321
    Abstract: Novel 6-bromo derivatives of cholesterol have the formula ##STR1## Such compounds are prepared from the known 6-iodocholesterol by treatment with cuprous bromide.These compounds, labelled with radioisotopes of Br-82 or Br-77, are localized in the adrenal, mammary and ovary tissue of female mammals and in the adrenal or prostate tissue of males when administered to such individuals. This provides a method for imaging adrenal, ovary or prostate tissue which is superior to use of the prior art 6-iodo-cholesterol.
    Type: Grant
    Filed: January 15, 1982
    Date of Patent: February 7, 1984
    Assignee: Merck Frosst Canada Inc.
    Inventors: Richard J. Flanagan, Leonard I. Wiebe