Patents Assigned to Merck GmbH
  • Publication number: 20120149943
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Application
    Filed: February 16, 2012
    Publication date: June 14, 2012
    Applicant: MERCK GMBH
    Inventors: Detlef PAULUTH, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Patent number: 7842845
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: November 30, 2010
    Assignee: Merck GmbH
    Inventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Patent number: 7411100
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: August 12, 2008
    Assignee: Merck GmbH
    Inventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Patent number: 7318950
    Abstract: The invention relates to chiral compounds of formula (I) R1—X1-(A1-Z1)m-G-(Z2-A2)n-X2—R2, wherein R1, R2, X1, X2, A1, A2, Z1, Z2, G, m and n have the meaning given in claim 1, to liquid crystalline mixtures comprising at least one chiral compound of formula (I), to chiral linear or crosslinked liquid crystalline polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula (I), to the use of chiral compounds of formula (I) and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula (I).
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: January 15, 2008
    Assignee: Merck GmbH
    Inventors: Peer Kirsch, Andreas Tangerbeck, Detlef Pauluth, Joachim Krause, Michael Heckmeier, Kazuaki Tarumi
  • Patent number: 7223450
    Abstract: The invention relates to chiral compounds of formula I wherein X1,X2,X1,X2,x1,x2,y1,y2,B,C,U1,U2,V1,V2,W1 and W2 have the meaning given in claim 1, to liquid crystal mixtures comprising at least one chiral compound of formula I, to chiral linear or crosslinked liquid crystal polymers obtainable by polymerizing a polymerizade mixture comprising at least one chiral compound of formula I, to the use of chiral compound of formula I and mixtures and polymers obtained thereof in liquid crystal display, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula I.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: May 29, 2007
    Assignee: Merck GmbH
    Inventors: Andreas Taugerbeck, Peer Kirsch, Detlef Pauluth, Joachim Krause, Juliane Suermann, Michael Heckmeier
  • Patent number: 7153974
    Abstract: An ionic liquid of the formula K+A? wherein K+ and A? are as defined herein, are suitable for use in electrochemical cells and capacitors. These ionic liquids can also be used in catalysis, as inert solvents, and as hydraulic liquids.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: December 26, 2006
    Assignee: Merck GmbH
    Inventors: Michael Schmidt, Udo Heider, Winfried Geissler, Nikolai Ignatyev, Volker Hilarius
  • Patent number: 6881722
    Abstract: Use of the polypeptide Saratin for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, wherein the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: April 19, 2005
    Assignee: Merck GmbH
    Inventors: Christopher Barnes, Matthias Frech, Uwe Hofmann, Johannes Gleitz, Wolfgang Strittmatter
  • Patent number: 6818051
    Abstract: The invention relates to particles with an opalescent effect, which have a particle size in the range from 5 &mgr;m to 5000 &mgr;m, comprising monodisperse spheres having a diameter of 50 nm to 2 &mgr;m with a standard deviation of less than 5% in a packed and regularly ordered structure which is three-dimensional in terms of domains and is mechanically stabilized by physical or chemical modification.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: November 16, 2004
    Assignee: Merck GmbH
    Inventors: Ralf Anselmann, Thomas Albrecht, Sara Rodriguez-Mozaz
  • Patent number: 6814735
    Abstract: A device for aligning a guide template used in resecting a distal femur in a one-compartment joint replacement. The device includes first and second support members (12;5), at least one rod-like transverse coupler (10;12), and a guide template (20). The support members each include a support surface (3;6) that is adjustable to lie in one plane (1) and designed to bear against one condyle (24;25) of a femur (21). The transverse coupler is arranged parallel to a transverse axis (2), which, in its end portion, is connected to the first support member (12) and is releasably connectable to the second support member (5). The transverse axis (2) extends parallel to a plane (1). The guide template (20) is displaceable parallel to the plane (1) relative to the second support member (5) and releasably lockable thereon.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: November 9, 2004
    Assignee: Biomet Merck GmbH
    Inventors: Nicolas Zirngibl, Roland Herzog, Peter Bauer
  • Patent number: 6764769
    Abstract: The invention relates to a novel apatite-coated metallic material having improved surface quality and biocompatibility, a process for its preparation, and the use of the material for bone implants, in particular dental implants, artificial joints and fixative material for accident surgery (osteosynthesis material). The coating in this case consists of a thick covering of hydroxyapatite crystals and/or amorphous calcium phosphate spheres having a specific surface area of less than 15 m2/g.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: July 20, 2004
    Assignee: Biomet Merck GmbH
    Inventors: Bernd Kotte, Jürgen Hofinger, Tanja Hebold
  • Publication number: 20030230737
    Abstract: The invention relates to liquid-crystalline compounds of the formula I, 1
    Type: Application
    Filed: December 21, 2001
    Publication date: December 18, 2003
    Applicant: Merck GmbH
    Inventors: Peer Kirsch, Florian Huber, Joachim Krause, Michael Heckmeier, Detlef Pauluth
  • Patent number: 6639031
    Abstract: The invention relates to a process for preparing a support material having an increased number of reactive groups and to a process for preparing coreactive surfaces that may have catalytic or cocatalytic properties.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: October 28, 2003
    Assignee: Merck GmbH
    Inventors: Eike Poetsch, Herwig Buchholz
  • Patent number: 6630210
    Abstract: The invention relates to pentafluorosulfuranylbenzene derivatives of the formula I in which R1, A1, A2, Z1, L1, L2, L3 and n are as defined herein and to the use thereof in liquid-crystalline media.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: October 7, 2003
    Assignee: Merck GmbH
    Inventors: Peer Kirsch, Joachim Krause, Michael Heckmeier
  • Publication number: 20030031983
    Abstract: The invention relates to a novel apatite-coated metallic material having improved surface quality and biocompatibility, a process for its preparation, and the use of the material for bone implants, in particular dental implants, artificial joints and fixative material for accident surgery (osteosynthesis material). The coating in this case consists of a thick covering of hydroxyapatite crystals and/or amorphous calcium phosphate spheres having a specific surface area of less than 15 m2/g.
    Type: Application
    Filed: June 6, 2002
    Publication date: February 13, 2003
    Applicant: Biomet Merck GmbH
    Inventors: Bernd Kotte, Jurgen Hofinger, Tanja Hebold
  • Patent number: 6475595
    Abstract: Fluorocyclohexene derivatives of formula I R1—(A1—Z1)n—A—(Z2—A2)m—Z3—B—(Z4—A3)p—R2  I, in which n, m, p, R1, R2, Z1, Z2, Z3, Z4, A1, A2, A3, A and B are as defined herein, are suitable for use in liquid crystal mediums. Also, difluorocyclohexanes of formula III R3—A*—(Z6—A7)m—Z7—Qr—R7  III, where R3, A*, Z6, A7, m, Z7, Q, r, and R4 are as defined herein, are suitable for use in liquid crystal mediums.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: November 5, 2002
    Assignee: Merck GmbH
    Inventors: Matthias Bremer, Detlef Pauluth, Joachim Krause, Michael Heckmeier, Peer Kirsch
  • Publication number: 20020160261
    Abstract: The invention relates to borate salts and to their use in electro-chemical cells.
    Type: Application
    Filed: January 24, 2002
    Publication date: October 31, 2002
    Applicant: Merck GmbH
    Inventors: Michael Schmidt, Andreas Kuhner, Klaus-Dieter Franz, Gerd-Volker Roschenthaler, German Bissky, Alexander Kolomeitsev, Alexander Kadyrov
  • Publication number: 20020130300
    Abstract: The invention relates to novel dioxane derivatives of the formula I
    Type: Application
    Filed: August 6, 2001
    Publication date: September 19, 2002
    Applicant: Merck GmbH
    Inventors: Matthias Bremer, Peer Kirsch, Sabine Schoen, Detlef Pauluth, Kazuaki Tarumi, Georg Lussem, Michael Heckmeier, Joachim Krause
  • Publication number: 20020114996
    Abstract: The present invention relates to mixtures of fluoroalkylphosphate salts and polymers, methods of producing same, and their use in electrolytes, batteries, capacitors, supercapacitors and galvanic cells.
    Type: Application
    Filed: November 9, 2001
    Publication date: August 22, 2002
    Applicant: Merck GmbH
    Inventors: Michael Schmidt, Frank Ott, Michael Jungnitz, Nikolai Ignatyev, Andreas Kuehner
  • Publication number: 20020090469
    Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I 1
    Type: Application
    Filed: October 19, 2001
    Publication date: July 11, 2002
    Applicant: Merck GmbH
    Inventors: Georg Lussem, Dagmar Klement, Volker Reiffenrath
  • Publication number: 20020091286
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I 1
    Type: Application
    Filed: January 8, 2002
    Publication date: July 11, 2002
    Applicant: Merck GmbH
    Inventor: Ekkehard Bartmann