Patents Assigned to Merck GmbH
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Publication number: 20120149943Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.Type: ApplicationFiled: February 16, 2012Publication date: June 14, 2012Applicant: MERCK GMBHInventors: Detlef PAULUTH, Peer Kirsch, Peter Baeuerle, Oliver Deeg
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Patent number: 7842845Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.Type: GrantFiled: May 22, 2009Date of Patent: November 30, 2010Assignee: Merck GmbHInventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
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Patent number: 7411100Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.Type: GrantFiled: May 22, 2006Date of Patent: August 12, 2008Assignee: Merck GmbHInventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
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Patent number: 7318950Abstract: The invention relates to chiral compounds of formula (I) R1—X1-(A1-Z1)m-G-(Z2-A2)n-X2—R2, wherein R1, R2, X1, X2, A1, A2, Z1, Z2, G, m and n have the meaning given in claim 1, to liquid crystalline mixtures comprising at least one chiral compound of formula (I), to chiral linear or crosslinked liquid crystalline polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula (I), to the use of chiral compounds of formula (I) and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula (I).Type: GrantFiled: June 25, 2001Date of Patent: January 15, 2008Assignee: Merck GmbHInventors: Peer Kirsch, Andreas Tangerbeck, Detlef Pauluth, Joachim Krause, Michael Heckmeier, Kazuaki Tarumi
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Patent number: 7223450Abstract: The invention relates to chiral compounds of formula I wherein X1,X2,X1,X2,x1,x2,y1,y2,B,C,U1,U2,V1,V2,W1 and W2 have the meaning given in claim 1, to liquid crystal mixtures comprising at least one chiral compound of formula I, to chiral linear or crosslinked liquid crystal polymers obtainable by polymerizing a polymerizade mixture comprising at least one chiral compound of formula I, to the use of chiral compound of formula I and mixtures and polymers obtained thereof in liquid crystal display, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula I.Type: GrantFiled: April 25, 2002Date of Patent: May 29, 2007Assignee: Merck GmbHInventors: Andreas Taugerbeck, Peer Kirsch, Detlef Pauluth, Joachim Krause, Juliane Suermann, Michael Heckmeier
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Patent number: 7153974Abstract: An ionic liquid of the formula K+A? wherein K+ and A? are as defined herein, are suitable for use in electrochemical cells and capacitors. These ionic liquids can also be used in catalysis, as inert solvents, and as hydraulic liquids.Type: GrantFiled: June 11, 2001Date of Patent: December 26, 2006Assignee: Merck GmbHInventors: Michael Schmidt, Udo Heider, Winfried Geissler, Nikolai Ignatyev, Volker Hilarius
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Patent number: 6881722Abstract: Use of the polypeptide Saratin for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, wherein the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices.Type: GrantFiled: August 23, 2001Date of Patent: April 19, 2005Assignee: Merck GmbHInventors: Christopher Barnes, Matthias Frech, Uwe Hofmann, Johannes Gleitz, Wolfgang Strittmatter
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Patent number: 6818051Abstract: The invention relates to particles with an opalescent effect, which have a particle size in the range from 5 &mgr;m to 5000 &mgr;m, comprising monodisperse spheres having a diameter of 50 nm to 2 &mgr;m with a standard deviation of less than 5% in a packed and regularly ordered structure which is three-dimensional in terms of domains and is mechanically stabilized by physical or chemical modification.Type: GrantFiled: November 14, 2002Date of Patent: November 16, 2004Assignee: Merck GmbHInventors: Ralf Anselmann, Thomas Albrecht, Sara Rodriguez-Mozaz
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Patent number: 6814735Abstract: A device for aligning a guide template used in resecting a distal femur in a one-compartment joint replacement. The device includes first and second support members (12;5), at least one rod-like transverse coupler (10;12), and a guide template (20). The support members each include a support surface (3;6) that is adjustable to lie in one plane (1) and designed to bear against one condyle (24;25) of a femur (21). The transverse coupler is arranged parallel to a transverse axis (2), which, in its end portion, is connected to the first support member (12) and is releasably connectable to the second support member (5). The transverse axis (2) extends parallel to a plane (1). The guide template (20) is displaceable parallel to the plane (1) relative to the second support member (5) and releasably lockable thereon.Type: GrantFiled: July 15, 2003Date of Patent: November 9, 2004Assignee: Biomet Merck GmbHInventors: Nicolas Zirngibl, Roland Herzog, Peter Bauer
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Patent number: 6764769Abstract: The invention relates to a novel apatite-coated metallic material having improved surface quality and biocompatibility, a process for its preparation, and the use of the material for bone implants, in particular dental implants, artificial joints and fixative material for accident surgery (osteosynthesis material). The coating in this case consists of a thick covering of hydroxyapatite crystals and/or amorphous calcium phosphate spheres having a specific surface area of less than 15 m2/g.Type: GrantFiled: June 6, 2002Date of Patent: July 20, 2004Assignee: Biomet Merck GmbHInventors: Bernd Kotte, Jürgen Hofinger, Tanja Hebold
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Publication number: 20030230737Abstract: The invention relates to liquid-crystalline compounds of the formula I, 1Type: ApplicationFiled: December 21, 2001Publication date: December 18, 2003Applicant: Merck GmbHInventors: Peer Kirsch, Florian Huber, Joachim Krause, Michael Heckmeier, Detlef Pauluth
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Patent number: 6639031Abstract: The invention relates to a process for preparing a support material having an increased number of reactive groups and to a process for preparing coreactive surfaces that may have catalytic or cocatalytic properties.Type: GrantFiled: September 12, 2000Date of Patent: October 28, 2003Assignee: Merck GmbHInventors: Eike Poetsch, Herwig Buchholz
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Patent number: 6630210Abstract: The invention relates to pentafluorosulfuranylbenzene derivatives of the formula I in which R1, A1, A2, Z1, L1, L2, L3 and n are as defined herein and to the use thereof in liquid-crystalline media.Type: GrantFiled: June 27, 2001Date of Patent: October 7, 2003Assignee: Merck GmbHInventors: Peer Kirsch, Joachim Krause, Michael Heckmeier
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Publication number: 20030031983Abstract: The invention relates to a novel apatite-coated metallic material having improved surface quality and biocompatibility, a process for its preparation, and the use of the material for bone implants, in particular dental implants, artificial joints and fixative material for accident surgery (osteosynthesis material). The coating in this case consists of a thick covering of hydroxyapatite crystals and/or amorphous calcium phosphate spheres having a specific surface area of less than 15 m2/g.Type: ApplicationFiled: June 6, 2002Publication date: February 13, 2003Applicant: Biomet Merck GmbHInventors: Bernd Kotte, Jurgen Hofinger, Tanja Hebold
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Patent number: 6475595Abstract: Fluorocyclohexene derivatives of formula I R1—(A1—Z1)n—A—(Z2—A2)m—Z3—B—(Z4—A3)p—R2 I, in which n, m, p, R1, R2, Z1, Z2, Z3, Z4, A1, A2, A3, A and B are as defined herein, are suitable for use in liquid crystal mediums. Also, difluorocyclohexanes of formula III R3—A*—(Z6—A7)m—Z7—Qr—R7 III, where R3, A*, Z6, A7, m, Z7, Q, r, and R4 are as defined herein, are suitable for use in liquid crystal mediums.Type: GrantFiled: March 31, 2000Date of Patent: November 5, 2002Assignee: Merck GmbHInventors: Matthias Bremer, Detlef Pauluth, Joachim Krause, Michael Heckmeier, Peer Kirsch
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Publication number: 20020160261Abstract: The invention relates to borate salts and to their use in electro-chemical cells.Type: ApplicationFiled: January 24, 2002Publication date: October 31, 2002Applicant: Merck GmbHInventors: Michael Schmidt, Andreas Kuhner, Klaus-Dieter Franz, Gerd-Volker Roschenthaler, German Bissky, Alexander Kolomeitsev, Alexander Kadyrov
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Publication number: 20020130300Abstract: The invention relates to novel dioxane derivatives of the formula IType: ApplicationFiled: August 6, 2001Publication date: September 19, 2002Applicant: Merck GmbHInventors: Matthias Bremer, Peer Kirsch, Sabine Schoen, Detlef Pauluth, Kazuaki Tarumi, Georg Lussem, Michael Heckmeier, Joachim Krause
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Publication number: 20020114996Abstract: The present invention relates to mixtures of fluoroalkylphosphate salts and polymers, methods of producing same, and their use in electrolytes, batteries, capacitors, supercapacitors and galvanic cells.Type: ApplicationFiled: November 9, 2001Publication date: August 22, 2002Applicant: Merck GmbHInventors: Michael Schmidt, Frank Ott, Michael Jungnitz, Nikolai Ignatyev, Andreas Kuehner
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Publication number: 20020090469Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I 1Type: ApplicationFiled: October 19, 2001Publication date: July 11, 2002Applicant: Merck GmbHInventors: Georg Lussem, Dagmar Klement, Volker Reiffenrath
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Publication number: 20020091286Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I 1Type: ApplicationFiled: January 8, 2002Publication date: July 11, 2002Applicant: Merck GmbHInventor: Ekkehard Bartmann