Patents Assigned to Merck Patent Gesellschaft Mit Beshrankter Haftung
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Patent number: 5747656Abstract: The invention relates to indicators for determine the proton concentration of strongly alkaline aqueous solutions which contain compounds of the formula (I) ##STR1## in which ##STR2##Type: GrantFiled: June 1, 1995Date of Patent: May 5, 1998Assignee: Merck Patent Gesellschaft Mit Beshrankter HaftungInventors: Wolfgang Fischer, Sylvia Baum, Thorsten Hartig, Michael Schleehahn
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Patent number: 5583111Abstract: The invention relates to novel polypeptides with antithrombin activity obtainable from extracts of tissues or secretions of leeches of the order Rhynchobdellida, particularly of the species Theromyzon tessulatum. The polypetides have molecular weights of about 14 kD, 9 kD and 3 kD and can be used in pharmaceutical compositions for the treatment of thrombosis related disorders and events.Type: GrantFiled: January 5, 1995Date of Patent: December 10, 1996Assignee: Merck Patent Gesellschaft Mit Beshrankter HaftungInventors: J urgen Hemberger, Roy Sawyer, Sabine Wolf, Johannes Dodt
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Patent number: 5562858Abstract: Hexafluoropropyl ethers of the formula I ##STR1## in which R, A.sup.1, Z.sup.1, L.sup.1, L.sup.2, m and n are as defined herein are suitable as components of liquid-cyrstalline media.Type: GrantFiled: April 13, 1995Date of Patent: October 8, 1996Assignee: Merck Patent Gesellschaft mit beshrankter HaftungInventors: Ekkehard Bartmann, Detlef Pauluth, Herbert Plach
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Patent number: 5561148Abstract: Novel oxazolidinone derivatives of the formula I ##STR1## in which R.sup.1 is a phenyl radical which is unsubstituted or is monosubstituted by CN, H.sub.2 N--CH.sub.2 --, A.sub.2 N--CH.sub.2 --, H.sub.2 N--C(.dbd.NH)--, H.sub.2 N--C(.dbd.NH)--NH--, H.sub.2 N--C(.dbd.NH)--NH--CH.sub.2 --, HO--NH--C(.dbd.NH)-- or HO--NH--C(.dbd.NH)--NH--,X is O, S, SO, SO.sub.2, --NH-- or --NA--,B is ##STR2## or ##STR3## A is alkyl having from 1 to 6 C atoms,R.sup.2 is H, A, Li, Na, K, NH.sub.4 or benzyl,R.sup.3 is H or (CH.sub.2).sub.n --COOR.sup.2,E is, in each case independently of each other, CH or N,Q is O, S or NH,m is 1, 2 or 3, andn is 0, 1, 2 or 3,and physiologically compatible salts thereof are provided, which inhibit the binding of fibrinogen to the corresponding receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and also tumors.Type: GrantFiled: September 22, 1994Date of Patent: October 1, 1996Assignee: Merck Patent Gesellschaft Mit Beshrankter HaftungInventors: Joachim Gante, Horst Juraszyk, Peter Raddatz, Hanns Wurziger, Guido Melzer, Sabine Bernotat-Danielowski
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Patent number: 5561145Abstract: Novel 4-aryloxy- or 4-arylthiopiperidine derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 are each, independently of one another, phenyl radicals which are unsubstituted or mono or disubstituted by A, OH, OA, aryloxy with 6-10 C atoms, aralkyloxy with 7-11 C atoms, --0--(CH.sub.2).sub.n --0--, Hal, CF.sub.3, NO.sub.2, NH.sub.2, NHA, NA.sub.2, NHAc, NAAc, NHSO.sub.2 A and/or NASO.sub.2 A,X is O, S, SO or SO.sub.2,m is 1, 2 or 3,n is 1 or 2,A is an alkyl radical with 1-6 C atoms,Hal is F, Cl, Br or landAc is alkanoyl with 1-8 C atoms, aralkanoyl with 1-10 C atoms or aroyl with 7-11 C atoms,and the physiologically acceptable salts thereof, show an effect influencing the central nervous system, in particular neuroleptic effect, with a negligible cataleptic effect.Type: GrantFiled: July 21, 1994Date of Patent: October 1, 1996Assignee: Merck Patent Gesellschaft Mit Beshrankter HaftungInventors: Helmut Prucher, Rudolf Gottschlich, Gerd Bartoszyk, Christoph Seyfried
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Patent number: 5560864Abstract: A liquid crystalline material in the form of an anisotropic gel containing a polymerized monotropic or enantiotropic liquid crystalline material and a low-molecular weight liquid crystalline material, wherein the polymerized material a) forms a permanently oriented network in the low-molecular weight liquid crystalline material b), wherein a) is obtained by (co)-polymerization of a chiral polymerizable compound, and a display cell with such a material. Also, novel bifunctional reactive chiral compounds, novel chiral vinylethers and (co)-polymerizable precursor materials.Type: GrantFiled: February 22, 1995Date of Patent: October 1, 1996Assignee: Merck Patent Gesellschaft Mit Beshrankter HaftungInventor: Mark Goulding
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Patent number: 5407746Abstract: The application relates to deagglomerated and readily dispersible platelet-like substrates with a high degree of softness, which are characterized by a content of 0.5-20% by weight of spherical particles having a small diameter in comparison with the platelet-like substrate, and to a process for their preparation and their use.Type: GrantFiled: September 28, 1993Date of Patent: April 18, 1995Assignee: Merck Patent Gesellschaft Mit Beshrankter HaftungInventors: Constanze Prengel, Johann Dietz, Angelika Thurn-Muller