Abstract: The present invention relates to an orally administrable galenic formulation allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active ingredients which are hydrophilic or ionizable in physiological media. The galenic formulation comprises at least one active ingredient, an absorption-promoting agent, and one or more pharmaceutically acceptable excipients.
Type:
Grant
Filed:
March 19, 2002
Date of Patent:
February 4, 2003
Assignee:
Merck Patentgesellschaft Mit
Inventors:
Olivier Saslawski, Philippe Giet, Dominique Michel, Thierry Holot
Abstract: The present invention relates to novel compositions containing a mixture of two or three bioflavonols like isoquercetin, quercetin-4′-glycoside, rutin and quercetin, which show differences in their pharmacokinetics. These compositions are useful as food supplements possessing preventive properties against damage to human tissues due to their antioxidant properties. Furthermore, these compositions secure a continuum of the presence of bioflavonols having the same aglycone in human plasma over an extended period of time.
Abstract: Amide and urea derivatives of the formula I
R1—(CH2)n—(Y)q—(Z)r—CO—NH—R2 (I)
in which R1, n, Y, q, Z, r and R2 have the meanings indicated in Claim 1, are potent 5-HT1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depressions, schizophrenia, compulsive ideas, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive behaviour (OCD), and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.
Type:
Grant
Filed:
October 3, 2001
Date of Patent:
January 21, 2003
Assignee:
Merck Patentgesellschaft
Inventors:
Christoph Van Amsterdam, Hartmut Greiner, Henning Boettcher, Gerd Bartoszyk, Juergen Harting, Lisa Matzen, Wilfried Rautenberg
Abstract: The invention concerns novel compound of general formula (1) in which: P, T1, T2, X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically acceptable bases. The invention also concerns methods for preparing these compounds and their applications as medicines. These compounds inhibit the aldose reductase enzyme and can be used in the treatment or prevention of peripheral and autonomous neurological diabetic complications, renal and ocular disorders such as cataract and retinopathy.
Type:
Grant
Filed:
March 17, 2000
Date of Patent:
January 21, 2003
Assignee:
Merck PatentGesellschaft mit
Inventors:
François Collonges, Hervé Dumas, Claude Lardy, Philippe Durbin
Abstract: The invention relates to a method for classifying and identifying by means of energy dispersion X-ray fluorescence analysis chemical substances whose X-ray fluorescence lines cannot be detected and which therefore cannot be classified by energy dispersion X-ray fluorescence analysis alone. Said method is characterized in that the sample to be analyzed is analyzed in its original packaging or natural state without prior processing in a sample vessel. According to the method the sample is: a) positioned in front of the measuring aperture in a sample chamber of an X-ray fluorescence apparatus; b) measured; and c) classified and identified by application of multivariate, statistical techniques to the measurement signals obtained, i.e., to the Compton and Rayleigh scattering.
Type:
Grant
Filed:
July 20, 2001
Date of Patent:
December 17, 2002
Assignee:
Merck Patentgesellschaft mit Beschrankter Haftung
Inventors:
Alexander Henrich, Hans-Helmut Itzel, Peter Hoffmann, Hugo Ortner
Abstract: The present invention relates to liquid-crystalline media which comprise at least one compound of the formula I and at least one compound of the formula II 1
Type:
Application
Filed:
October 29, 2001
Publication date:
August 8, 2002
Applicant:
MERCK PATENTGESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Abstract: The invention relates to a process for the preparation of vinylene carbonate of the formula (I)
by reacting a monohaloethylene carbonate of the formula (II)
in which X is a halogen atom, with a dehydrohalogenating agent at elevated temperature in the presence of an organic solvent, characterized in that the organic solvent employed is ethylene carbonate.
The process according to the invention enables vinylene carbonate to be prepared in a simple manner and in high yield. The vinylene carbonate prepared in accordance with the invention can be used for various applications.
Type:
Grant
Filed:
November 20, 2000
Date of Patent:
May 28, 2002
Assignee:
Merck Patentgesellschaft
Inventors:
Bernhard Seifert, Sylvia Becker, Mark Neuschütz
Abstract: The invention relates to polymer beads comprising an anisotropic polymer material with helically twisted structure, to their use in reflective films, spraying or printing inks or as pigments, for optical or electrooptical, decorative or security applications, to a reflective film comprising one or more polymer beads in a transmissive binder, and to a security marking or security device comprising one or more polymer beads or comprising a reflective film.
Type:
Application
Filed:
September 18, 2001
Publication date:
May 9, 2002
Applicant:
MERCK PATENTGESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Inventors:
Mathias Kuntz, David Coates, Simon Greenfield, John Patrick
Abstract: The invention relates to a process for preparing electrically conductive pigments based on F−- and/or PO43−-doped tin mixed oxides applied as an electrically conductive layer to a substrate, in which, first of all, SnO2-coated substrates are prepared by precipitation and subsequent calcining and then, in further process steps, this SnO2 layer is converted into a tin mixed oxide layer doped with F− and/or PO43−. The invention further relates to electrically conductive pigments prepared by the process of the invention, to the use of these pigments for pigmenting lacquers, printing inks, plastics systems or coatings, and to lacquers, printing inks, plastics systems or coatings pigmented with an electrically conductive pigment prepared by the process of the invention.
Type:
Application
Filed:
October 19, 2001
Publication date:
May 9, 2002
Applicant:
MERCK PATENTGESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Abstract: Silane compounds of the formula SiR1R2R3R4 wherein R1 to R4 are as defined herein are useful as additives in electrolytes for improving the properties of electrochemical cells.
Type:
Application
Filed:
June 7, 2001
Publication date:
January 31, 2002
Applicant:
MERCK PATENTGESELLSCHAFT
Inventors:
Michael Schmidt, Andreas Kuhner, Dagmar Petigk
Abstract: The present invention provides a column endpiece for a chromatography column. The column endpiece includes a base part, an extension piece for a discharge tube, and a frit. The frit produces a pressure drop per unit length that is at least twice as great as the pressure drop per unit length created in the sorbent packing when the eluent is flowing through.
Type:
Grant
Filed:
September 13, 1999
Date of Patent:
January 9, 2001
Assignee:
Merck PatentGesellschaft
Inventors:
Hans Daniel Jakob Mueller, Axel Delp, Hans-Dieter Harders, Joseph H. Spurk, Peter F. Pelz