Abstract: Compounds of the formula I are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer. R1 denotes H, Hal, CF3, NO2, A, [C(R3)2]nN(R3)2, [C(R3)2]nHet1, OR3, O[C(R3)2]nN(R3)2, O[C(R3)2]nS(O)mR3, O[C(R3)2]nCOOR3, O[C(R3)2]nCOON(R3)2, O[C(R3)2]nHet1, O[C(R3)2]nN(R3)Het1, O[C(R3)2]nPh, or O[C(R3)2]nCyc. R2 denotes H or CH3. R3 denotes H or A. V denotes H or Hal. X denotes O or N(R3). Y denotes phenylene, pyridin-diyl, thiophen-diyl, 1,3-thiazol-diyl or pyrazol-diyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal and/or A. Z denotes CON(R3)2, phenyl, Het4 or —O-A.
Type:
Application
Filed:
July 22, 2020
Publication date:
August 25, 2022
Applicant:
Merck Patent GmbH
Inventors:
Dieter Dorsch, Andreas Blum, Hans-Peter Buchstaller
Abstract: The invention relates to a liquid-crystalline medium having a nematic phase comprising one or more compounds of formula X wherein the parameters have the meaning given in the text, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type and to the use of the compounds of formula X for improvement of the transmission and/or response times of a liquid-crystalline medium which comprises one or more additional mesogenic compounds, as well as to the compounds of formula X.
Abstract: The invention relates to specific phenanthrenes, the use of the compound in an electronic device, and an electronic device containing at least one of said compounds. The invention further relates to a method for producing the compound and a formulation and composition containing one or more of the compounds.
Type:
Grant
Filed:
September 5, 2019
Date of Patent:
August 23, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Teresa Mujica-Fernaud, Arne Buesing, Frank Voges, Jonas Kroeber
Abstract: A switchable optical device is provided having a first substrate (11), a second substrate (12) and a seal (114). The two substrates (11, 12) and the seal (114) are arranged such that a cell having a cell gap is formed and a switchable medium (10) is located inside the cell gap. The first substrate (11) has a first transparent electrode (21) and the second substrate (12) has a second transparent electrode (22). The electrodes (21, 22) are facing towards the cell gap. The two substrates (11, 12) are arranged such that the first substrate (11) has a first region (71) adjacent to a first edge (41) of the first substrate (11) which does not overlap with the second substrate (12) and the second substrate (12) has a second region (72) which does not overlap with the first substrate (11). A first electrically conducting busbar (31) is arranged in the first region (71) and a second electrically conducting busbar (32) is arranged in the second region (72).
Abstract: A coating composition, and uses thereof, including a solvent, metal oxide nanoparticles dispersed in this solvent, and a high carbon polymer dissolved in this solvent, where the high carbon polymer includes a repeat unit of structure (1), a hydroxybiphenyl repeat unit of structure (2) and a moiety containing a fused aromatic containing moiety of structure (3) where R1 and R2 are independently selected from the group of hydrogen, an alkyl and a substituted alkyl, Ar is an unsubstituted or substituted fused aromatic ring and X1 is an alkylene spacer, or a direct valence bound.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
August 23, 2022
Assignee:
Merck Patent GMBH
Inventors:
M. Dalil Rahman, Huirong Yao, JoonYeon Cho, Munirathna Padmanaban, Elizabeth Wolfer
Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal media comprising them, and to the use of the polymerizable compounds and liquid crystalline media for optical, electro-optical and electronic purposes, in particular in liquid crystalline displays, especially in liquid crystalline displays of the polymer sustained alignment type.
Type:
Grant
Filed:
April 22, 2020
Date of Patent:
August 16, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Qiong Tong, Nico Schwebel, Constanze Brocke, Kaja Christina Deing, Julian Vogt, Elisabeth Meyer
Abstract: A fluorinated imide salt compound of the present invention is a compound represented by General Formula (1). In General Formula (1), m represents 1 or 2, n represents an integer from 1 to 4, ? represents 1 or 2, and X?+ represents an ?-valent metal ion, a primary ammonium ion, a secondary ammonium ion, a tertiary ammonium ion, a quaternary ammonium ion, or NH4+.
Abstract: The instant invention provides for a new method of treating colorectal cancer (CRC) and metastases thereof in subjects, and preferably also of other solid cancers and metastases thereof in subjects, wherein said method preferably depends on whether the patient shows certain specific proteins levels in one or more body fluids prior to or during treatment, wherein said treatment comprises the administration of at least one pan ?v integrin inhibitor to a patient, a medicament for use in said new methods, and a method of predicting the outcome of a treatment with at least one pan ?v integrin inhibitor based on said specific protein levels in one or more body fluids of the patient.
Abstract: The present invention relates to alumina flakes having a defined thickness and particle size distribution and to their use in varnishes, paints, automotive coatings, printing inks, masterbatches, plastics and cosmetic formulations and as substrate for effect pigments.
Abstract: A holding device (1) for automated stopcock actuation, comprising a base body (2); and a driver (3) rotatably received at the base body (2). The holding device (1) has a receptacle (4) for removably receiving at least a part of a stopcock (A) and is configured such that the driver (3) can engage with and actuate a handle (B) of the stopcock (A) received in the receptacle (4) upon rotation of the driver (3), and a first fixation member (5) that is configured to allow selective fixation of the stopcock (A) in the receptacle (4).
Abstract: A compound of formula I, Further, a method of production of a compound of formula I, the use of said compounds in LC media, and LC media comprising one or more compounds of formula I. Further, a method of production of such LC media, the use of such media in LC devices, and a LC device comprising a LC medium according to the present invention. Also, a process for the fabrication of such a liquid crystal display and the use of the liquid crystal mixtures according to the invention for the fabrication of such a liquid crystal display.
Abstract: The present application relates to a polymer containing at least one structural unit of a formula (I). The polymer is suitable for use in an electronic device.
Type:
Grant
Filed:
June 18, 2018
Date of Patent:
August 9, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Beate Burkhart, Katja Scheible, Nils Koenen, Holger Heil
Abstract: The present invention relates to compounds, which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.
Type:
Grant
Filed:
January 29, 2018
Date of Patent:
August 9, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Amir Parham, Jonas Kroeber, Dominik Joosten, Aurélie Ludemann, Tobias Grossmann
Abstract: The present invention relates to formulations for the preparation of organic electronic devices which comprise at least one organic functional material and a mixture of at least two different solvents wherein a first organic solvent exhibits a lower boiling point than a second organic solvent and said first organic solvent exhibits a higher viscosity than said second organic solvent.
Type:
Grant
Filed:
November 17, 2016
Date of Patent:
August 9, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Philip Edward May, Pawel Miskiewicz, Li Wei Tan, Daniel Walker
Abstract: The present invention relates to a formulation containing at least one organic functional material and at least two different solvents, a first organic solvent A and a second organic solvent B, wherein the first organic solvent A comprises a group, which is capable of receiving or giving a hydrogen bonding, and wherein the second organic solvent B has a boiling point in the range from 150 to 350° C. and the solubility of the at least one organic functional material in the second organic solvent is ?5 g/l.
Type:
Grant
Filed:
June 26, 2017
Date of Patent:
August 9, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Gaëlle Béalle, Christoph Leonhard, Hsin-Rong Tseng, Manuel Hamburger, Anja Jatsch
Abstract: The present invention relates to alumina flakes having a defined thickness and particle size distribution and to their use in varnishes, paints, automotive coatings, printing inks, masterbatches, plastics and cosmetic formulations and as substrate for effect pigments.
Abstract: According to the present invention, a siliceous film forming composition, which is capable of filling trenches having narrow widths and high aspect ratios and forming a thick film, can be provided. A siliceous film forming composition comprising: (a) a block copolymer comprising a linear and/or cyclic block A having a polysilane skeleton comprising 5 or more silicon and a block B having a polysilazane skeleton comprising 20 or more silicon, and (b) a solvent.
Abstract: The present invention relates to metal complexes and to electronic devices, especially organic electroluminescent devices, comprising these metal complexes. The metal complex is, for example, represented by a compound formula (1) M(L)n(L?)m, containing a substructure M(L)n of the formula (2), and where M is iridium or platinum.