Patents Assigned to Merck Patents GmbH
  • ISOTHIOCYANATO TOLANE DERIVATIVES
    Publication number: 20210122977
    Abstract: The present invention relates to isothiocyanato tolane derivatives of formula I in which the occurring groups have the meanings indicated in claim 1, to a process for their preparation, to liquid-crystalline media comprising same and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, in particular for microwave phased-array antennas.
    Type: Application
    Filed: September 11, 2018
    Publication date: April 29, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Dmitry USHAKOV, Beate SCHNEIDER, Carsten FRITZSCH, Michael WITTEK, Dagmar KLASS
  • Liquid-crystal medium
    Patent number: 10988691
    Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising one or more compounds of the formula I and II in which the parameters have the respective meanings indicated in claim 1, and to liquid-crystal displays, especially active-matrix displays and in particular displays of the vertically aligned mode, containing these media.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: April 27, 2021
    Assignee: Merck Patent GmbH
    Inventors: Takanori Takeda, Masahiko Okamura, Norihiko Tanaka, Yasushi Sugiyama
  • GCN2 inhibitors and uses thereof
    Patent number: 10988477
    Abstract: The present invention provides compounds inhibiting General amino acid Control Non-derepressible 2 kinase (“GCN2”), compositions thereof, and methods of using the same for treating various disorders, such as cancer.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: April 27, 2021
    Assignees: Merck Patent GmbH, Vertex Pharmaceuticals Incorporated
    Inventors: Andrew Bayly, Matthew Bleich, Jean-Damien Charrier, James Dodd, Steven Durrant, Meredith Suzanne Eno, Gorka Etxebarria I Jardi, Simon Everitt, Damien Fraysse, Shazia Kelly, Ronald Knegtel, Igor Mochalkin, Michael Mortimore, Kiri North, Filippos Porichis, Robert Pullin, Alistair Rutherford, Pierre-Henri Storck, Heather Clare Twin, Yufang Xiao
  • Liquid crystal medium and liquid crystal device
    Patent number: 10988692
    Abstract: The invention relates to a medium comprising at least 60% of one or more compounds of formula I wherein R11, R12, MG11, MG12 and Sp1 have the meaning given herein below, to the use of such media in liquid crystal devices, in particular in flexoelectric liquid crystal devices, and to a flexoelectric liquid crystal device comprising a liquid crystal medium according to the present invention.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: April 27, 2021
    Assignee: Merck Patent GmbH
    Inventors: Simon Siemianowski, Konstantin Schneider
  • Materials for organic electroluminescent devices
    Patent number: 10991892
    Abstract: The present invention relates to carbazole derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a method for producing the compounds according to the invention and to electronic devices comprising same.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: April 27, 2021
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Thomas Eberle, Anja Jatsch, Christof Pflumm, Jonas Valentin Kroeber
  • INTERFERENCE PIGMENTS
    Publication number: 20210115260
    Abstract: The present invention relates to interference pigments based on platelet-shaped substrates which are coated with at least four high refractive layers and to the use thereof, inter alia in paints, coatings, printings inks, plastics and in particular in cosmetic formulations. The interference pigments show a moderate chroma and can be used as effect pigments, as filler pigments and as protection agent against near infrared radiation, VIS and high energy light.
    Type: Application
    Filed: March 14, 2018
    Publication date: April 22, 2021
    Applicant: Merck Patent GmbH
    Inventors: Michael TERMER, Jutta ZUR LAGE, Anett MOSCHNER, Lilia HEIDER
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20210115337
    Abstract: The present invention relates to liquid-crystalline media comprising one or more compounds selected from the group of compounds of formula I in which the parameters have the meaning indicated in Claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
    Type: Application
    Filed: March 13, 2018
    Publication date: April 22, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Michael WITTEK, Dagmar KLASS
  • AGGRECAN BINDING IMMUNOGLOBULINS
    Publication number: 20210115117
    Abstract: The present invention relates to immunoglobulins that specifically bind Aggrecan and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of Aggrecan.
    Type: Application
    Filed: June 4, 2018
    Publication date: April 22, 2021
    Applicants: Ablynx N.V., Merck Patent GmbH
    Inventors: Soren Steffensen, Gerald Beste, Guy Hermans, Hans Gühring, Christoph Ladel, Lars Toleikis
  • OPITCAL DEVICE COMPRISING A SWITCHABLE LAYER AND AT LEAST ONE OPTICAL LAYER
    Publication number: 20210116748
    Abstract: The invention relates to a switchable optical device (10) having a layer structure comprising at least one switchable layer (15) and at least one optical layer (20, 22). The at least one switchable layer (15) comprises a liquid-crystalline material and at least one dye. The at least one optical layer (20, 22) has at least one reflection band (32) which includes at least a first part of the visible spectrum and has at least one transmission band (30, 34) which includes at least a second part of the visible spectrum. The absorption spectrum of the at least one switchable layer (15) is adjusted by means of the at least one dye such that the light transmission through the switchable optical device (10) for incident light in the visible light spectrum for at least one of the states of the switchable layer (15) is set to a predetermined transmission spectrum.
    Type: Application
    Filed: May 8, 2018
    Publication date: April 22, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Ties DE JONG, Casper VAN OOSTEN
  • Crystalline form of (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)-methanol
    Publication number: 20210113572
    Abstract: A crystalline form of (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)-phenyl]-(6-methoxy-pyridazin-3-yl)-methanol can be prepared as a pharmaceutical composition.
    Type: Application
    Filed: March 28, 2018
    Publication date: April 22, 2021
    Applicant: Merck Patent GmbH
    Inventors: Michael LANGE, Clemens Kuehn, Thomas Fuchss, David Maillard, Marcel Breuning, Marco Poma, Edoardo Burini
  • Chiral compounds
    Patent number: 10982149
    Abstract: Chiral compounds of formula I wherein the paramters have the meaning given in claim 1, liquid crystal mixtures comprising at least one chiral compound of formula I, to chiral linear or crosslinked liquid crystal polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula I, to the use of chiral compound of formula I and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and a liquid crystal display comprising a mixture comprising at least one chiral compound of formula I.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: April 20, 2021
    Assignee: Merck Patent GmbH
    Inventors: Matthias Bremer, Edward Plummer, Thomas Eichhorn, Peter Schreiner, Christian Kuehn
  • Liquid crystalline medium
    Patent number: 10982150
    Abstract: The present invention relates to liquid crystalline media comprising one or more naphthothiadiazol derivatives of formula I, in which R11, R12, A11, A12, A21, A22, Z11, Z12, Z21, Z22, W, X11, X12, L, r, s and t have the meanings indicated in claim 1, to the use of such liquid crystal media for optical, electro-optical and electronic purposes, in particular in devices for regulating the passage of energy from an outside space into an inside space, for example in windows.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: April 20, 2021
    Assignee: Merck Patent GmbH
    Inventors: Peer Kirsch, Rene Lutz, Michael Junge, Ursula Patwal
  • Domain-exchanged antibody
    Patent number: 10982008
    Abstract: The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: April 20, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Gordana Wozniak-Knopp, Sylvia Dietrich, Florian Rüker, Alec Gross, Stefan Becker
  • Materials for organic electroluminescent devices
    Patent number: 10981880
    Abstract: The present invention relates to fluorene derivatives and to electronic devices in which these compounds are used as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: April 20, 2021
    Assignee: Merck Patent GmbH
    Inventors: Adam W. Franz, Rémi M. Anémian
  • Materials for electronic devices
    Patent number: 10985330
    Abstract: The application relates to compounds having functional substituents in a specific spatial arrangement, to devices comprising same, and to the preparation and use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 20, 2021
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Tobias Grossmann, Anja Jatsch, Thomas Eberle, Jonas Kroeber, Christof Pflumm, Lars Dobelmann-Mara
  • Crystalline modifications of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride and N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts
    Patent number: 10981864
    Abstract: The present invention relates to novel crystalline modifications of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications and processes of manufacturing and pharmaceutical formulations thereof.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: April 20, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Axel Becker, Gilmary Gallon, Christoph Saal, Clemens Kuehn
  • CRYSTALLINE SODIUM SALT OF 5-METHYL-(6S)-TETRAHYDROFOLIC ACID
    Publication number: 20210107902
    Abstract: The present invention is directed to a crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to sodium is from 1:1.51 to 1:2.5 and/or hydrates and/or solvates thereof, as well as, a process of obtaining the same.
    Type: Application
    Filed: March 28, 2018
    Publication date: April 15, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Rudolf MOSER, Viola GROEHN, Fritz BLATTER, Martin SZELAGIEWICZ, Ruth BOEHNI STAMM, Markus RUETTIMANN
  • Positive working photosensitive material
    Patent number: 10976662
    Abstract: The present application for patent relates to a light-sensitive positive working photosensitive composition especially useful for imaging thick films using a composition which gives very good film uniformity and promotes a good process latitude against feature pattern collapse in patterns created upon imaging and developing of these films.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: April 13, 2021
    Assignee: Merck Patent GmbH
    Inventors: Weihong Liu, PingHung Lu, Chunwei Chen, SookMee Lai, Yoshiharu Sakurai, Aritaka Hishida
  • Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Patent number: 10975075
    Abstract: The compounds are imidazolonylquinoline compounds of the following formula and are useful in the inhibition, regulation and/or modulation of signal transduction by kinases, in particular ATM kinase, furthermore for the treatment of diseases which relate to ATM kinase, in particular cancer, and which compounds can be supplied in pharmaceutical compositions and kits.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: April 13, 2021
    Assignee: Merck Patent GmbH
    Inventors: Thomas Fuchss, Kai Schiemann
  • Liquid-crystalline medium
    Patent number: 10975308
    Abstract: A liquid-crystalline media comprising one or more compounds of formula S where the parameters have the meaning defined in claim 1, and one or more compounds of the formula I and one or more compounds of the formula II or one or more compounds of the formula I and one or more compounds of the formula III or one or more compounds of the formula II and one or more compounds of the formula III or one or more compounds of the formula I and one or more compounds of the formula II and one or more compounds of the formula III: in which the parameters have the meaning indicated in claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: April 13, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Atsutaka Manabe, Rocco Fortte, Dagmar Klass, Renate Seeger