Patents Assigned to Merck Sharp & Dhome Corp.
  • Pyrazole carboxamides as inhibitors of 11-?-hydroxysteroid dehydrogenase-1
    Patent number: 7659408
    Abstract: Pyrazole carboxamides of structural formula I are selective inhibitors of the 11?-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: February 9, 2010
    Assignee: Merck Sharp & Dhome Corp.
    Inventors: Ying-Duo Gao, Xin Gu, Nancy J. Kevin, Sherman T. Waddell