Patents Assigned to Merck Sharp & Dohme B.V.
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Publication number: 20210403560Abstract: Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.Type: ApplicationFiled: September 8, 2021Publication date: December 30, 2021Applicant: Merck Sharp & Dohme B.V.Inventors: Gregory John Carven, Hans van Eenennaam, Gradus Johannes Dulos
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Patent number: 11077050Abstract: The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).Type: GrantFiled: March 19, 2018Date of Patent: August 3, 2021Assignees: Merck Sharp & Dohme Corp., Merck Sharp & Dohme B.V.Inventors: Sachin Mittal, Irina Kazakevich, Himanshu Bhattacharjee, Peter Bakker, Luke Schenck, David J. Goldfarb, Amitava Mitra, Donna Carroll, Nazia Khawaja
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Patent number: 11051508Abstract: A mixing apparatus (1) for mixing slaughter offal with a preservative agent, the apparatus comprising an offal collection tank (3) with a bottom (4) provided with a discharge opening (5) connectable to a closable discharge, an agitator (8) extending into the offal collection tank, and a pump unit (9) operatively connectable to the discharge, wherein the apparatus further comprises a preservative reservoir (7) mounted on top of the collection tank (3). A collection and preservation system is provided, wherein the addition of preservation agent can be strictly controlled, can easily and quickly be installed and connected when it is to be used. After use, the system is easily removed and cleaned.Type: GrantFiled: April 11, 2019Date of Patent: July 6, 2021Assignee: Merck Sharp & Dohme B.V.Inventors: Adolph Bartholomeus Gijtenbeek, Harry van Tuijn, Marinus Johannes Gerardus Maria Ploegmakers
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Patent number: 11040184Abstract: The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.Type: GrantFiled: September 5, 2018Date of Patent: June 22, 2021Assignee: MERCK SHARP & DOHME B.V.Inventors: Dennis Cornelis Franciscus Beelen, Martin Van Harmelen, Robertus Theodoor Maria Moormann, Maurice Petrus Wilhelmus Tak
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Patent number: 10934296Abstract: The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.Type: GrantFiled: February 14, 2019Date of Patent: March 2, 2021Assignee: Merck Sharp & Dohme B.V.Inventors: Tjeerd A. Barf, Christiaan Gerardus Johannes Maria Jans, Adrianus Petrus Antonius de Man, Arthur A. Oubrie, Hans C. A. Raaijmakers, Johannes Bernardus Maria Rewinkel, Jan Gerard Sterrenburg, Jacobus C. H. M. Wijkmans
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Patent number: 10918515Abstract: A vaginal ring applicator having a polymeric barrel and at least one friction reducing agent, wherein the barrel is a flattened cylinder having two slightly curved and opposing sides connected by two arcs, wherein the barrel extends between an insertion end and a plunger end; and a plunger extending between distal and proximal ends, wherein the distal end of the plunger engages the plunger end of the barrel and wherein the plunger fits telescopically within the barrel.Type: GrantFiled: March 30, 2016Date of Patent: February 16, 2021Assignee: Merck Sharp & Dohme B.V.Inventors: Owen Callaghan, Cornelis P. M. Govers, Joris M. Swaak, Marco A. Voogsgerd, Mario A. A. de Zeeuw, Jesper Laursen, Klaas Sipkens
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Patent number: 10821277Abstract: The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.Type: GrantFiled: September 6, 2018Date of Patent: November 3, 2020Assignee: MERCK SHARP & DOHME B.V.Inventors: Dennis Cornelis Franciscus Beelen, Martin Van Hermelen, Robertus Theodoor Maria Moormann, Maurice Petrus Wilhelmus Tak
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Publication number: 20200289493Abstract: The present invention provides methods of treatment for recurrent cancer(s) through combination therapy with an agent that inhibits programmed death-1 protein (PD-1) signaling and an agent that inhibits poly [ADP-ribose] polymerase (PARP) signaling.Type: ApplicationFiled: May 9, 2018Publication date: September 17, 2020Applicants: TESARO, Inc., MERCK SHARP & DOHME B.V.Inventors: Dmitri Bobilev, Bruce Dezube, Peng Sun, Andrew R. Ferguson
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Publication number: 20200289406Abstract: The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).Type: ApplicationFiled: March 19, 2018Publication date: September 17, 2020Applicants: MERCK SHARP & DOHME CORP., MERCK SHARP & DOHME B. V.Inventors: Sachin Mittal, Irina Kazakevich, Himanshu Bhattacharjee, Peter Bakker, Luke Schenck, David J. Goldfarb, Amitava Mitra, Donna Carroll, Nazia Khawaja
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Publication number: 20200131272Abstract: The present invention relates to anti-CD27 antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Applicants: Merck Sharp & Dohme Corp., Merck Sharp & Dohme B.V.Inventors: Amy M. Beebe, Jason Ka Jen Cheung, Veronica Juan, Laurence Fayadat-Dilman, Svetlana Sadekova, Jerelyn Wong, Hans van Eenennaam, Andrea van Elsas, Lars Guelen, Thierry Olivier Fischmann, Winifred W. Prosise
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Patent number: 10556957Abstract: The present invention relates to anti-CD27 antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.Type: GrantFiled: September 25, 2017Date of Patent: February 11, 2020Assignees: Merck Sharp & Dohme Corp., Merck Sharp & Dohme B. V.Inventors: Amy M. Beebe, Jason Ka Jen Cheung, Veronica Juan, Laurence Fayadat-Dilman, Svetlana Sadekova, Jerelyn Wong, Hans van Eenennaam, Andrea van Elsas, Lars Guelen, Thierry Olivier Fischmann, Winifred W. Prosise
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Publication number: 20190300618Abstract: The present invention relates to anti-CD27 antibodies, as well as use antibodies in the treatment of diseases such as cancer and infectious disease.Type: ApplicationFiled: September 25, 2017Publication date: October 3, 2019Applicants: Merck Sharp & Dohme Corp., Merck Sharp & Dohme B.V.Inventors: Amy M. Beebe, Jason Ka Jen Cheung, Veronica Juan, Laurence Fayadat-Dilman, Svetlana Sadekova, Jerelyn Wong, Hans van Eenennaam, Andrea van Elsas, Lars Guelen, Thierry Olivier Fischmann, Winifred W. Prosise
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Patent number: 10301281Abstract: The present disclosure relates to forms of a CCR5 inhibitory compound, (4,6-dimethylpyrimidin-5-yl)(4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-piperazin-1-yl)-4-methylpiperidin-1-yl)methanone.Type: GrantFiled: November 11, 2015Date of Patent: May 28, 2019Assignees: MERCK SHARP & DOHME CORP., MERCK SHARP & DOHME B.V.Inventors: Alfred Y. Lee, William De Wildt
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Patent number: 10239883Abstract: The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.Type: GrantFiled: August 3, 2017Date of Patent: March 26, 2019Assignee: Merck Sharp & Dohme B.V.Inventors: Tjeerd A. Barf, Christiaan Gerardus Johannes Maria Jans, Adrianus Petrus Antonius de Man, Arthur A. Oubrie, Hans C. A. Raaijmakers, Johannes Bernardus Maria Rewinkel, Jan Gerard Sterrenburg, Jacobus C. H. M. Wijkmans
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Patent number: 10155259Abstract: The invention relates to FSH receptor antagonist according to general formula I or a pharmaceutically acceptable salt thereof and to a pharmaceutical composition containing the same. The compounds can be used for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, and for the treatment of uterine fibroids and other menstrual-related disorders.Type: GrantFiled: July 29, 2015Date of Patent: December 18, 2018Assignee: Merck Sharp & Dohme B.V.Inventors: Wesley Peter Blackaby, Martin De Kort, Mark Enthoven, Paul Stuart Hinchliffe, Christian Bernard Matthijs Poulie, Cornelis Marius Timmers, Saskia Verkaik
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Patent number: 10092739Abstract: The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.Type: GrantFiled: July 17, 2008Date of Patent: October 9, 2018Assignee: MERCK SHARP & DOHME B.V.Inventors: Dennis Cornelis Franciscus Beelen, Martin Van Harmelen, Robertus Theodoor Maria Moormann, Maurice Petrus Wilhelmus Tak
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Publication number: 20180177949Abstract: A backstop for a syringe can include a base having a first surface and an opposing second surface. A skirt can extend outwardly from the second surface of the base. An opening can extend through the base. The opening can be surrounded by the skirt. A first extension can extend generally perpendicularly from the second surface at an outer periphery of the base. A second extension can extend generally perpendicularly from the second surface at the outer periphery of the base. The second extension can be diametrically opposed to the first extension.Type: ApplicationFiled: June 20, 2016Publication date: June 28, 2018Applicant: Merck Sharp & Dohme B.V.Inventors: Jacobus A. de Waal Malefijt, Dennis Broeke, Sander H. W. de Jong
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Publication number: 20180111996Abstract: Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.Type: ApplicationFiled: November 13, 2017Publication date: April 26, 2018Applicant: Merck Sharp & Dohme B.V.Inventors: Gregory John Carven, Hans van Eenennaam, Gradus Johannes Dulos
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Publication number: 20180086841Abstract: The present invention relates to anti-CD27 antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.Type: ApplicationFiled: September 25, 2017Publication date: March 29, 2018Applicants: Merck Sharp & Dohme Corp., Merck Sharp & Dohme B.V.Inventors: Amy M. Beebe, Jason Ka Jen Cheung, Veronica Juan, Laurence Fayadat-Dilman, Svetlana Sadekova, Jerelyn Wong, Hans van Eenennaam, Andrea van Elsas, Lars Guelen, Thierry Olivier Fischmann, Winifred W. Prosise
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Patent number: 9925200Abstract: The present invention is directed to stable pharmaceutical formulations. More specifically, the present invention is directed to stable pharmaceutical formulations of testosterone undecanoate.Type: GrantFiled: June 15, 2015Date of Patent: March 27, 2018Assignee: Merck Sharp & Dohme B.V.Inventor: Gerritdina G. Schoonus-Gerritsma