Patents Assigned to Merck Sharp & Dohme Corpl
  • THIADIAZOLYL - OXIMINOACETIC ACID DERIVATIVE COMPOUNDS
    Publication number: 20170369459
    Abstract: Thiadiazolyl-oximinoacetic acid derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds. Compound (1) (TATD) is commercially available (CAS No. 76028-96-1). It has now been discovered that the thiadiazolyl-oximinoacetic acid derivative compound (1) (TATD) can be prepared from dimethyl malonate (SM 1, CAS No. 108-59-8) according to methods described herein. The methods provide products having desirable purity.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 28, 2017
    Applicant: Merck Sharp & Dohme Corpl
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas