Abstract: The invention herein is directed to immunoassays for the detection of A?42 oligomers. The inventive assays are based on the observations herein that the presence of A?42 oligomers in a preparation is directly related to a decrease in a C-terminal (CT) immunosignal and a correlated increase in an N-terminal (NT) immunosignal, relative to the immunosignal generated in the absence of A?42 oligomers, in an A?42 CT and NT ELISA assay and an A?42 CT AlphaLISA assay. The invention herein involves the use of these assays alone or in combination to screen for inhibitors of A?42 oligomerization.

Abstract: The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.