Patents Assigned to Merck Sharp & Dohme LLC
  • PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES
    Publication number: 20230075760
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Application
    Filed: September 22, 2022
    Publication date: March 9, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui, Julie Marie Skinner
  • METHODS FOR MONITORING THE PROGRESS OF POLYSACCHARIDE SIZE-REDUCTION
    Publication number: 20230073288
    Abstract: The present invention relates to Polysaccharide Size-Reduction Monitoring Methods useful for the non-invasive, and accurate monitoring of the progress of a polysaccharide size-reduction process.
    Type: Application
    Filed: February 24, 2021
    Publication date: March 9, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jennifer C. P. Wang, Kelsey A. Richards, Jayesh Desai, Bhumit A. Patel, Michael A. Winters, Patrick M. McHugh, Philip R. Kuhl, John P. Higgins, Michael I. Larkin, Michelle H. Chen
  • METHODS OF SEPARATING HOST CELL LIPASES FROM AN ANTI-LAG3 ANTIBODY PRODUCTION
    Publication number: 20230077205
    Abstract: Provided herein are methods of separating host cell lipases from an anti-LAG3 antibody or antigen binding fragment in chromatographic processes and methods of improving polysorbate-80 stability in an anti-LAG3 antibody formulation by separating host cell lipases from the anti-LAG3 antibody or antigen binding fragment using chromatographic processes. Also provided are pharmaceutical compositions comprising an anti-LAG3 antibody or antigen binding fragment and less than 2 ppm of a host cell lipase.
    Type: Application
    Filed: January 28, 2021
    Publication date: March 9, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Colette M. CUTLER, Hong LI, Sketa PATEL, Sandra E. RIOS, John P. WELSH
  • USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR
    Publication number: 20230062119
    Abstract: The present invention includes methods of identifying a patient who will likely be responsive to treatment with a protein arginine N-methyltransferase 5 inhibitor, or a pharmaceutically acceptable salt thereof, and methods of treating the same.
    Type: Application
    Filed: December 16, 2020
    Publication date: March 2, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Benjamin Nicholson, Rachel Allison Altura, Razvan Cristescu, David John Curtis, Ian Philip Street
  • FORMULATIONS OF DENGUE VIRUS VACCINE COMPOSITIONS
    Publication number: 20230061673
    Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a glycol or sugar alcohol, optionally an alkali or alkaline salt and an amino acid; and formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar of at least 150 mg/ml, a carrier, and optionally an alkali or alkaline salt and an amino acid.
    Type: Application
    Filed: July 26, 2022
    Publication date: March 2, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Michael S. Ryan, Sherrie-Ann P. Martin, Morrisa Jones, Justin Stanbro, Akhilesh Bhambhani, Jeffrey Thomas Blue, Heidi Joanne Pixley, Erin J. Green-Trexler, Lynne Ann Isopi
  • INDAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES
    Publication number: 20230066268
    Abstract: The present invention relates to novel Indazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5 and R6 are as defined herein. The present invention also relates to compositions comprising at least one Indazole Derivative, and methods of using the Indazole Derivatives for treating or preventing a herpesvirus infection in a patient.
    Type: Application
    Filed: December 15, 2020
    Publication date: March 2, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Andrew John Cooke, Christopher D. Cox, Scott D. Edmondson, Charles Lee Jayne, Anilkumar G. Nair, Jeffrey W. Schubert, Jason W. Skudlarek, David M. Tellers, De-Yi Yang
  • STAPLED TRIAZOLE CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS
    Publication number: 20230063794
    Abstract: The stapled peptides of the present invention, and pharmaceutically acceptable salts thereof, are co-agonists of the glucagon and GLP-1 receptors, and may be useful in the treatment, prevention and suppression of diseases mediated by the glucagon receptor and the GLP-1 receptor, including but not limited to, metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
    Type: Application
    Filed: December 18, 2020
    Publication date: March 2, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Elisabetta Bianchi, Qiaolin Deng, Songnian Lin, Federica Orvieto, Anandan Palani, Antonello Pessi, Tomi K. Sawyer
  • Pharmaceutical formulation comprising incretin-insulin conjugates
    Patent number: 11590237
    Abstract: This disclosure relates to stable aqueous pharmaceutical formulations comprising a therapeutically effective amount of an incretin-insulin conjugate as well as methods of using the same, and aqueous pharmaceutical formulations containing an incretin-insulin conjugate which are stable and which provide a protracted pharmacodynamics profile, which include L-arginine HCl and phenol (or m-cresol) as stabilizing agents. The invention also provide a method of treating a patient or individual having a metabolic disease, comprising administering to the patient or individual an effective amount of any of the aqueous pharmaceutical formulations described herein.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: February 28, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Shuai Shi, Valentyn Antochshuk
  • Substituted pyrazole-pyrimidines, variants thereof, and uses therefore
    Patent number: 11591315
    Abstract: Disclosed herein are substituted pyrazole-pyrimidine compounds of Formula I and variants thereof for the treatment, for example, of diseases associated with P2X purinergic receptors: In one embodiment, the P2X3 and/or P2X2/3 antagonists disclosed herein are potentially useful, for example, for the treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: February 28, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Ronald Charles Hawley, Prabha Ibrahim, Anthony P. Ford, Joel R. Gever
  • COMBINATION CANCER TREATMENT USING A PD-1 ANTAGONIST, AN ILT4 ANTAGONIST, AND LENVATINIB OR SALTS THEREOF
    Publication number: 20230058779
    Abstract: Provided herein are methods of treating cancer (e.g., RCC), which comprise administering to a human patient in need thereof: (a) a PD-1 antagonist; (b) an ILT4 antagonist; and (c) lenvatinib represented by Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are kits containing such agents and uses of therapeutic combinations of such agents for the treatment of cancer.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 23, 2023
    Applicants: Merck Sharp & Dohme LLC, EISAI R&D Management Co., Ltd.
    Inventors: Rachel A. Altura, Philip E. Brandish, Rodolfo Fleury Perini
  • BICYCLIC HETEROCYCLE COMPOUNDS METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES
    Publication number: 20230054782
    Abstract: The present invention relates to novel Bicyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5, R6, and R7 are as defined herein. The present invention also relates to compositions comprising at least one Bicyclic Heterocycle Compound, and methods of using the Bicyclic Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 23, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Andrew John Cooke, Brendan M. Crowley, Marc A. Labroli, Michael Aaron Plotkin, Izzat T. Raheem, Ling Tong, Deyou Sha
  • HAND HELD DEVICE FOR AUTOMATICALLY REMOVING AND REPLACING SCREW-ON CAPS FOR CRYOGENIC TUBES, CRYOGENIC VIALS AND MICROTUBES
    Publication number: 20230055698
    Abstract: A handheld, battery operated device that, when activated, will grip a screw-cap on the top of a cryogenic vial, microtube, test tube or other pharmaceutical product container, and automatically rotate the cap in a counterclockwise direction to remove the cap, and automatically rotate the cap in a clockwise direction to fasten the cap back on the cryogenic vial, microtube, test tube or other pharmaceutical product container.
    Type: Application
    Filed: August 15, 2022
    Publication date: February 23, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventor: Robert A. Levin
  • Process for synthesis of a phenoxy diaminopyrimidine compound
    Patent number: 11584724
    Abstract: Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: February 21, 2023
    Assignees: Merck Sharp & Dohme LLC, Werthenstein BioPharma GmbH
    Inventors: Kevin M. Maloney, Kallol Basu, Michael James Di Maso, Guy R. Humphrey, Alfred Y. Lee, Feng Peng, Hong Ren, Siwei Zhang
  • HPV VACCINE
    Publication number: 20230048144
    Abstract: The present disclosure provides, among other things, a single-dose vaccine composition that includes a chitosan adjuvant and HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82, where the single-dose vaccine composition provides enhanced or comparable HPV vaccine response in comparison to a similar multiple-dose vaccine formulated without such chitosan adjuvant.
    Type: Application
    Filed: August 4, 2022
    Publication date: February 16, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Andrew Bett, Colleen M. Barr, John P. Bilello, Pedro J. Cejas, Amy S. Espeseth, Tong-Ming Fu, Erica L. Strable, Sara Zimmermann
  • METHODS FOR TREATING CANCER USING A COMBINATION OF A PD-1 ANTAGONIST, AN ILT4 ANTAGONIST, AND CHEMOTHERAPEUTIC AGENTS
    Publication number: 20230050449
    Abstract: Provided herein are methods of treating cancer (e.g., NSCLC), which comprise administering to a human patient in need thereof: (a) a PD-1 antagonist; (b) an ILT4 antagonist; and (c) one or more chemotherapeutic agents. Also provided are pharmaceutical compositions and kits containing such agents for the treatment of cancer.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 16, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Philip E. Brandish, Rachel A. Altura, Bilal Piperdi
  • PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES
    Publication number: 20230041441
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
    Type: Application
    Filed: September 27, 2022
    Publication date: February 9, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui, Julie Marie Skinner
  • Stabilized RSV F proteins and uses thereof
    Patent number: 11566051
    Abstract: The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: January 31, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Lan Zhang, Arthur Fridman, Eberhard Durr, Andrew Bett
  • Long-acting co-agonists of the glucagon and GLP-1 receptors
    Patent number: 11566057
    Abstract: Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: January 31, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Anandan Palani, Qiaolin Deng, Chunhui Huang, Yuping Zhu, Elisabetta Bianchi, Federica Orvieto
  • Radial map data visualization
    Patent number: 11568001
    Abstract: A visualization system generates for display one or more radial maps that represent data values for a plurality of parameters measured for groups of entities. Each group of rows of the radial map represents a group of entities for whom the parameters are measured and compared against a baseline or control group, while each column represents a measured parameter. If the visualization system determines that an entity has a data value for a measured parameter that deviates from the control group value by more than a threshold amount, the system visually distinguishes the outlier value from the other geometric shapes in the radial map. Additionally, two or more radial maps may be simultaneously displayed on a visual interface based on correlations between data points for groups of entities.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: January 31, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventor: Oriana Jeannette Love
  • PRE-FILLED SYRINGE STOPPER RETAINER HAVING PROJECTIONS OR RECEIVERS AND METHODS OF USING SAME
    Publication number: 20230025555
    Abstract: A stopper retainer comprises a base having an upper surface, a lower surface, and a perimeter; a sidewall joined to the base around the perimeter, the sidewall having a raised height to define an interior cavity with the base; and a plurality of projections extending from the lower surface of the base, each of the plurality of projections being sized to at least partially fit within a lumen of a syringe barrel.
    Type: Application
    Filed: December 11, 2020
    Publication date: January 26, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Ophelia Wells, Wail Rasheed, Raymond K. Seto, Cassie Megna, Eduardo Cristofolli, Michael F. Tormey