Patents Assigned to Merck
  • Liquid-crystalline mixtures
    Patent number: 10723950
    Abstract: The present application relates to mixtures which have liquid-crystalline properties. The application furthermore relates to the use of the mixtures in devices which regulate the transmission of light through an area element.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: July 28, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Michael Junge, Ursula Patwal, Peer Kirsch
  • Liquid crystalline medium
    Patent number: 10723948
    Abstract: The invention relates to dielectrically positive liquid crystalline media comprising a compound of formula I wherein the parameters have the meaning given in claim 1 and to liquid crystal displays comprising these media, especially to active matrix displays and in particular to TN and IPS mode displays.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 28, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Harald Hirschmann, Martina Windhorst, Christian Hock, Andreas Pohle, Axel Jansen
  • Naphthalene compounds for liquid-crystalline mixtures
    Patent number: 10723951
    Abstract: The invention relates to compounds of the formula I, in which R, A, Z, m, L1, L2, L3 and X have the meanings indicated in Claim 1, to a process for the preparation thereof, and to liquid-crystalline media comprising at least one compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: July 28, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Christian Jasper, Susann Gunst, Helmut Haensel, Brigitte Schuler
  • Metal complexes containing allyl ligands
    Patent number: 10723749
    Abstract: Metal complexes containing substituted allyl ligands and methods of using such metal complexes to prepare metal-containing films are provided.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: July 28, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Bin Xi, Joby Eldo, Charles Dezelah, Ravi Kanjolia, Guo Liu
  • Hydrophilic compounds for optically active devices
    Patent number: 10723713
    Abstract: The present invention relates to novel compounds, particularly to hydrophilic compounds, comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices. The present application also relates to ophthalmic devices comprising such compounds.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: July 28, 2020
    Assignee: Merck Patent GmbH
    Inventors: Lars Dobelmann-Mara, Stefan Riedmueller, Martin Schraub
  • NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE
    Publication number: 20200230117
    Abstract: Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.
    Type: Application
    Filed: April 24, 2017
    Publication date: July 23, 2020
    Applicants: IOMet Pharma Ltd., Merck Sharp & Dohme Corp.
    Inventors: Phillip M. Cowley, Meredeth Ann McGowan, Thomas J. Brown, Yongxin Han, Kun Liu, Qinglin Pu, Alan Wise, Hongjun Zhang, Hua Zhou
  • ALPHA-ALUMINA FLAKES
    Publication number: 20200231827
    Abstract: The present invention relates to alumina flakes having a defined thickness and particle size distribution and to their use in varnishes, paints, automotive coatings, printing inks, masterbatches, plastics and cosmetic formulations and as substrate for effect pigments.
    Type: Application
    Filed: April 8, 2020
    Publication date: July 23, 2020
    Applicant: Merck Patent GmbH
    Inventors: Ryuta SUZUKI, Gerhard PFAFF, Sabine SCHOEN, Noriyuki MATSUDA, Katsuhisa NITTA
  • HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES
    Publication number: 20200231559
    Abstract: The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.
    Type: Application
    Filed: February 14, 2018
    Publication date: July 23, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Lars DOBELMANN-MARA, Stefan RIEDMUELLER, Martin SCHRAUB
  • PHOSPHOR AND A COMPOSITION
    Publication number: 20200231872
    Abstract: The present invention relates to a phosphor and a composition.
    Type: Application
    Filed: July 24, 2018
    Publication date: July 23, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Hiroshi OKURA, Stephan DERTINGER, Tarunjot SINGH, Ryuta SUZUKI, Kazuhisa AZUMA, Eiji NISHIHARA, Tadashi ISHIGAKI, Koutoku OHMI, Ryota YAMANASHI, Kenji TODA, Daniel SZABO, Noriyuki MATSUDA
  • N3-SUBSTITUTED IMINOPYRIMIDINONES AS ANTIMALARIAL AGENTS
    Publication number: 20200230140
    Abstract: The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
    Type: Application
    Filed: February 13, 2017
    Publication date: July 23, 2020
    Applicants: Merck Sharp & Dohme Corp., The Walter and Eliza Hall Institute of Medical Research
    Inventors: Tanweer A. Khan, Jared N. Cumming, David B. Olsen, Justin A. Boddey, Alan F. Cowman, Brad E. Sleebs
  • NOVEL SUBSTITUTED N'-HYDROXYCARBAMIMIDOYL-1,2,5-OXADIAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS
    Publication number: 20200231606
    Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Application
    Filed: August 24, 2017
    Publication date: July 23, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kun Liu, Abdelghani Achab, Purakkattle Biju, Timothy A. Cernak, Yongqi Deng, Xavier Fradera, Liangqin Guo, Yongxin Han, Shuwen He, Joseph Kozlowski, Derun Li, Guoqing Li, Qinglin Pu, Zhi-Cai Shi, Wensheng Yu, Hongjun Zhang
  • ALPHA-ALUMINA FLAKES
    Publication number: 20200231828
    Abstract: The present invention relates to alumina flakes having a defined thickness and particle size distribution and to their use in varnishes, paints, automotive coatings, printing inks, masterbatches, plastics and cosmetic formulations and as substrate for effect pigments.
    Type: Application
    Filed: April 8, 2020
    Publication date: July 23, 2020
    Applicant: Merck Patent GmbH
    Inventors: Ryuta SUZUKI, Gerhard PFAFF, Sabine SCHOEN, Noriyuki MATSUDA, Katsuhisa NITTA
  • Auto injector with separate needle injection
    Patent number: 10716899
    Abstract: An auto injector having sequential control of needle insertion and dose injection is disclosed. A syringe with a needle is movably positioned in a housing between a first position in which the needle is accommodated inside the housing and a second position in which the needle protrudes outside the housing. A plunger rod tube has at least one locking member configured to normally lock a plunger rod to the plunger rod tube. A syringe driver applies a force to the syringe to move the syringe together with plunger rod tube, plunger rod and plunger rod driver from the first position to the second position. In the second position, the locking member is unlocked and releases the plunger rod to thereby activate the plunger rod driver to advance the plunger rod in the syringe for delivering of at least one dose of medicament.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: July 21, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Soeren Bechmann, Flemming Madsen, Esben W. Johansen
  • Methods for treating MS using pyrimidine and pyridine compounds with BTK inhibitory activity
    Patent number: 10716788
    Abstract: The present invention provides methods of treating MS using pyrimidine and pyridine compounds which are inhibitors of Bruton's tyrosine kinase (BTK).
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: July 21, 2020
    Assignee: Merck Patent GmbH
    Inventor: Tammy Dellovade
  • HUMANIZED ANTIBODY FOR TREATING OR PREVENTING COGNITIVE DISORDERS, PROCESS FOR PRODUCING THE SAME, AND AGENT FOR TREATING OR PREVENTING COGNITIVE DISORDERS USING THE SAME
    Publication number: 20200223916
    Abstract: The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phosphorylated at the serine at position 413.
    Type: Application
    Filed: January 17, 2020
    Publication date: July 16, 2020
    Applicants: TEIJIN PHARMA LIMITED, MERCK SHARP & DOHME CORP.
    Inventors: Hiroshi Eguchi, Takashi Murakami, Naoko Namiki, Akira Tanokura, Jeanne E. Baker, Sophie Parmentier Batteur, Angela Marie Jablonski, Daniel Stephen Malashock, Carl Mieczkowski, Gopalan (Raghu) Raghunathan
  • SANITATION ASSEMBLY AND METHOD
    Publication number: 20200222565
    Abstract: A sanitation assembly (1) comprising a first chamber (2) with a first volume (2a) for receiving a first fluid, and a second chamber (3) with a second volume (3a) for receiving a second fluid, wherein the first volume (2a) communicates with an outlet (6) of the assembly (1) via a first valve mechanism (4) configured to allow discharge of the fluid from the first volume (2a) to the outlet (6) at a predefined first opening pressure, wherein the second volume (3a) communicates with the outlet (6) of the assembly (1) via a second valve mechanism (5) configured to allow discharge of the fluid from the second volume (3a) to the outlet (6) at a predefined second opening pressure, and wherein the predefined second opening pressure of the second valve mechanism (5) is higher than the predefined first opening pressure of the first valve mechanism (4).
    Type: Application
    Filed: September 24, 2018
    Publication date: July 16, 2020
    Applicant: Merck Patent GmbH
    Inventor: Fabrice COMINI
  • METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F
    Publication number: 20200222550
    Abstract: The present invention provides a method of producing a polysaccharide-protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation step prior to filtration to remove free polysaccharide.
    Type: Application
    Filed: January 30, 2018
    Publication date: July 16, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Michael Albert Winters, John E. MacNair
  • FLUORINE COMPOUNDS
    Publication number: 20200223976
    Abstract: The present invention relates to fluorine compounds (I), (II) and (III), to processes for the preparation thereof, and to the use thereof.
    Type: Application
    Filed: September 24, 2018
    Publication date: July 16, 2020
    Applicant: Merck Patent GmbH
    Inventors: Reiner FRIEDRICH, Fabian KOCH
  • COMPOUNDS FOR THE TREATMENT OF MALARIA
    Publication number: 20200223220
    Abstract: The present invention provides methods of treating malaria by administration of a compound of Formula (I): or a pharmaceutically acceptable salt of said compound, to a subject in need thereof, wherein the variables X, R1, R3, R4, R5, A, B, L, m and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
    Type: Application
    Filed: March 24, 2020
    Publication date: July 16, 2020
    Applicants: Merck Sharp & Dohme Corp., The Walter and Eliza Hall Institute of Medical Research
    Inventors: Tanweer A. Khan, Jared N. Cumming, David B. Olsen, Justin A. Boddey, Alan F. Cowman, Brad E. Sleebs
  • Intermediates and procedures for the synthesis of functional materials
    Patent number: 10711138
    Abstract: The present invention relates to heteroaromatic compounds which have two different reactive groups, their use in the synthesis of asymmetrically substituted compounds, and synthesis processes in which the compounds according to the invention are reacted sequentially with two different compounds, whereby an asymmetrically substituted compound is formed.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: July 14, 2020
    Assignee: Merck Patent GmbH
    Inventors: Peer Kirsch, Susann Gunst