Patents Assigned to Merck
  • Patent number: 10435566
    Abstract: This invention relates to polymer particles preferably with surface functionality for charge retention, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, electrophoretic displays comprising such particle, and new polymerizable dyes.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: October 8, 2019
    Assignee: Merck Patent GmbH
    Inventors: Louise Diane Farrand, Jonathan Henry Wilson, Mark James, Christopher Lutz, Nathan Smith, Mark John Goulding
  • Patent number: 10435410
    Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 8, 2019
    Assignee: MERCK SHARP & DOHME CORPORATION
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R. Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Patent number: 10435398
    Abstract: The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: October 8, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Scott D. Kuduk, Nigel Liverton, Yunfu Luo
  • Patent number: 10439145
    Abstract: The present invention relates to compounds which are suitable for use in electronic devices, preferably organic electroluminescent devices.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: October 8, 2019
    Assignee: Merck Patent GmbH
    Inventors: Holger Heil, Lara-Isabel Rodriguez, Fabrice Eckes, Oliver Kaufhold, Anja Gerhard, Stefan Riedmueller
  • Patent number: 10435506
    Abstract: The present invention relates to thiadiazolopyridine polymers, their synthesis and their use. The present invention further relates to organic electronic devices comprising such thiadiazolopyridine polymers.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: October 8, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: William Mitchell, Mansoor D'Lavari
  • Patent number: 10435472
    Abstract: The instant invention provides for a new method of treating bone metastasis diseases in subjects, wherein said method preferably depends on whether the subject shows certain specific proteins levels in one or more body fluids prior to or during treatment, wherein said treatment comprises the administration of at least one pan ?v integrin inhibitor to a subject, a medicament for use in said new methods, and a method of predicting the outcome of a treatment with at least one pan ?v integrin inhibitor based on said specific protein levels in one or more body fluids of the subject.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: October 8, 2019
    Assignee: Merck Patent GmbH
    Inventors: Josef Straub, Eike Staub
  • Patent number: 10435628
    Abstract: The invention relates to a polymerizable LC medium with negative optical dispersion, a polymer film with negative optical dispersion obtainable from such a medium, and the use of the polymerizable LC medium and polymer film in optical, electro optical, electronic, semiconducting or luminescent components or devices.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: October 8, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Joseph Sargent, Owain Llyr Parri, Kevin Adlem, Hassan Arasi
  • Patent number: 10435386
    Abstract: A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: October 8, 2019
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Cheol K. Chung, Mark E. Scott, Paul Gerard Bulger, Kevin Michael Belyk, John Limanto, Guy R. Humphrey
  • Publication number: 20190298655
    Abstract: The present invention relates to a directly shaped tablet from extrudate based on polyvinyl alcohol (PVA), which can be used for pharmaceutical products, and that due to its improved properties can be better easily shaped into tablets, which show anti-alcohol-induced dose dumping effect. Furthermore, this invention refers to pharmaceutical tablets composition comprising extruded polyvinyl alcohol as carrier matrix and can improve the solubility of API.
    Type: Application
    Filed: November 6, 2017
    Publication date: October 3, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Mengyao ZHENG, Alessandro ELIA
  • Publication number: 20190300547
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 3, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Lars BURGDORF, Dieter DORSCH, Christos TSAKLAKIDIS
  • Publication number: 20190300791
    Abstract: The invention relates to polyfluorinated additives for use as components in liquid-crystal mixtures, to liquid-crystal mixtures which comprise these compounds, and to liquid-crystal displays based on these mixtures.
    Type: Application
    Filed: December 5, 2017
    Publication date: October 3, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Peer KIRSCH, Qiong TONG, Helga HAAS, Kaja Christina DEING, Christoph MARTEN, Andreas POHLE, Reiner FRIEDRICH
  • Publication number: 20190300513
    Abstract: Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.
    Type: Application
    Filed: April 1, 2019
    Publication date: October 3, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Michael D. Altman, Brandon D. Cash, Matthew Lloyd Childers, Jared N. Cumming, Duane E. DeMong, Andrew Marc Haidle, Timothy J. Henderson, James P. Jewell, Matthew A. Larsen, Jongwon Lim, Min Lu, Ryan D. Otte, Benjamin Wesley Trotter
  • Publication number: 20190300618
    Abstract: The present invention relates to anti-CD27 antibodies, as well as use antibodies in the treatment of diseases such as cancer and infectious disease.
    Type: Application
    Filed: September 25, 2017
    Publication date: October 3, 2019
    Applicants: Merck Sharp & Dohme Corp., Merck Sharp & Dohme B.V.
    Inventors: Amy M. Beebe, Jason Ka Jen Cheung, Veronica Juan, Laurence Fayadat-Dilman, Svetlana Sadekova, Jerelyn Wong, Hans van Eenennaam, Andrea van Elsas, Lars Guelen, Thierry Olivier Fischmann, Winifred W. Prosise
  • Patent number: 10428220
    Abstract: This invention relates to polymer particles, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, and electrophoretic displays comprising such particles.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: October 1, 2019
    Assignee: Merck Patent GmbH
    Inventors: Louise Diane Farrand, Claire Topping, Mark John Goulding
  • Patent number: 10428024
    Abstract: Compounds of the formula I in which X, Y, R1 and R2 have the meanings indicated in Claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: October 1, 2019
    Assignee: MERCK PATENT GMBH
    Inventor: Hans-Peter Buchstaller
  • Patent number: 10428080
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK? inhibitors.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: October 1, 2019
    Assignee: Merck Patent GmbH
    Inventors: Brian A. Sherer, Srinivasa Karra, Yufang Xiao
  • Patent number: 10431704
    Abstract: This invention relates to a method for producing a photodetector based on the deposition of precursor system having a liquid phase. The photodetectors are characterized by a certain group of semiconductor materials which can be used as the absorber in solar-blind UV detectors. A facile route for the formation of thin layers of such absorber materials is disclosed.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: October 1, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Rebekah Hooker, Deepak Ranjan Deshmukh, Pawel Miskiewicz, Andreas Klyszcz, Klaus Bonrad, Thomas Albrecht
  • Patent number: 10429129
    Abstract: Methods for preparing dried pellets of biological materials are described. The pellets can have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a solid surface followed by microwave vacuum drying the frozen droplets. These methods are useful for preparing dried pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: October 1, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Akhilesh Bhambhani, Robert K. Evans, Jessica Sinacola, Rebecca Lizzano
  • Patent number: 10428076
    Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: October 1, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Raphaelle Berger, Yi-Heng Chen, Guoqing Li, Joie Garfunkle, Hong-Dong Li, Shouwu Miao, Subharekha Raghavan, Cameron J. Smith, John Stelmach, Alan Whitehead, Rui Zhang, Yong Zhang, Jianmin Fu, Gang Ji, Falong Jiang
  • Publication number: 20190296242
    Abstract: The invention relates to polymers having at least one asymmetrical structural unit of the following formula (I): wherein A, B, Ar1, Ar2, Ar3 and Ar4, n, m, o and p can have the meaning as defined in claim 1, to methods for the production thereof and to the use thereof in electronic or optoelectronic devices, in particular in organic electroluminescent devices, so-called OLEDs (OLED=Organic Light Emitting Diodes). The present invention also relates to organic electroluminescent devices which contain said polymers.
    Type: Application
    Filed: November 27, 2017
    Publication date: September 26, 2019
    Applicant: Merck Patent GmbH
    Inventors: Beate Burkhart, Katja Maria Scheible, Nils Koenen, Holger Heil