Patents Assigned to Merck
  • 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
    Patent number: 10329289
    Abstract: The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 25, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jianming Bao, Xiaolei Gao, Sandra L. Knowles, Chunsing Li, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Debra L. Ondeyka, Andrew W. Stamford, Fengqi Zhang
  • Heteroaryl compounds as BTK inhibitors and uses thereof
    Patent number: 10329270
    Abstract: The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: June 25, 2019
    Assignee: Merck Patent GmbH
    Inventors: Hui Qiu, Richard D. Caldwell, Constantin Neagu, Igor Mochalkin, Lesley Liu-Bujalski, Reinaldo Jones, Devon Tate, Theresa L. Johnson, Anna Gardberg
  • Perfluoroalkyl group-containing bismuth compounds as lewis acid catalysts
    Patent number: 10328423
    Abstract: The invention relates to perfluoroalkyl group-containing bismuth compounds as Lewis acid catalysts, to specific compounds, and to the method for the production thereof.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 25, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Berthold Theo Hoge, Sven Joerg-Ruediger August Solyntjes, Anne Julia Bader, Nikolai Ignatiev
  • Pyrrolotriazine inhibitors of IRAK4 activity
    Patent number: 10329295
    Abstract: The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 25, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jongwon Lim, Michael D. Altman, Jason D. Brubaker, Craig R. Gibeau
  • Compounds for the inhibition of indoleamine-2,3-dioxygenase
    Patent number: 10329297
    Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of IDO, and for the treatment of IDO-related disorders.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: June 25, 2019
    Assignee: Merck Patent GmbH
    Inventor: Brian A. Sherer
  • ORGANIC SEMICONDUCTING COMPOUNDS COMPRISING A TETRAAZAPYRENE CORE
    Publication number: 20190185480
    Abstract: The present invention relates to organic semiconducting compounds of formula (I) wherein X1 is C, Si or Ge; X2 is 0, S or Se; and X3 is N or P as well as to organic electronic devices comprising such organic semiconducting compounds.
    Type: Application
    Filed: August 8, 2017
    Publication date: June 20, 2019
    Applicant: Merck Patent GmbH
    Inventors: Daniel BECKER, Andreas TAUGERBECK, Martin SCHRAUB
  • LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT
    Publication number: 20190185754
    Abstract: A liquid-crystalline media (LC media) containing a low-molecular-weight, non-polymer component, and a combination of self-alignment additives for vertical alignment of two or more of the specified kinds (formulae IA to IM). The combination of two or more self-alignment additives affect homeotropic (vertical) alignment of the LC media at a surface or the cell surfaces of a liquid-crystal display (LC display).
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Graziano ARCHETTI, Izumi SAITO, Rocco FORTTE, Edward Plummer, Dmitry USHAKOV, Helmut HAENSEL, Melanie KLASEN-MEMMER
  • 3-ARYL- HETEROARYL SUBSTITUTED 5-TRIFLUOROMETHYL OXADIAZOLES AS HISTONEDEACETYLASE 6 (HDAC6) INHIBITORS
    Publication number: 20190185462
    Abstract: The present invention is directed to substituted 5-trifluoromethyl oxadiazole compounds of generic formula (I) or a pharmaceutically acceptable salt thereof. In particular, the invention is directed to a class of aryl and heteroaryl substituted 5-trifluoromethyl oxadiazole compounds of formula I which may be useful as HDAC6 inhibitors for treating cellular proliferative diseases, including cancer, neurodegenerative diseases, such as schizophrenia and stroke, as well as other diseases.
    Type: Application
    Filed: June 19, 2017
    Publication date: June 20, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Abbas Walji, Richard Berger, Craig A. Stump, Kelly Ann S. Schlegel, James J. Mulhearn, Thomas J. Greshock, Deping Wang, Mark E. Fraley, Kristen G. Jones
  • LIQUID-CRYSTAL MEDIA AND LIGHT MODULATION ELEMENT
    Publication number: 20190185746
    Abstract: The present invention relates to liquid crystalline (LC) medium, to a method of its production and to the use of such LC media in polymer network liquid crystalline (PNLC) light modulation elements operated in the normally transparent mode. Furthermore, the present invention relates to such light modulation elements, as such, to the use of such light modulation elements as light shutters for transparent OLED displays, to the use of such light modulation elements in smart windows, and to a method of production of such light modulation elements according to the present invention.
    Type: Application
    Filed: September 4, 2017
    Publication date: June 20, 2019
    Applicant: Merck Patent GmbH
    Inventors: Dong-Mee SONG, Hyun-Woo BAE, Jung-Min LEE, Yong-Kuk YUN
  • ANTIVIRAL PRODRUGS OF TENOFOVIR
    Publication number: 20190183912
    Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 20, 2019
    Applicants: Merck Sharp & Dohme Corp., IDENIX PHARMACEUTICALS LLC
    Inventors: Daniel Da Costa, Cyril B. Dousson, David Dukhan, Jean-Laurent Paparin, Houcine Rahali, Izzat Raheem
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20190185747
    Abstract: The present invention relates to liquid-crystalline media comprising one or more compounds of formula Q and one or more compounds selected from the group of compounds of formulae T, U and I wherein the occurring groups and parameters have the meaning indicated in claim 1. The present invention further relates to the use of these liquid-crystal media, in particular in components for high-frequency technology, and to components of this type which contain media according to the invention, and to the production and use of these components. The components according to the invention are suitable, in particular, as phase shifters in the microwave and millimetre wave region, for microwave and millimetre wave array antennae and very particularly for so-called tunable “reflectarrays”.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 20, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Michael WITTEK, Renate SEEGER
  • ORGANIC SEMICONDUCTORS
    Publication number: 20190189925
    Abstract: The invention relates to novel organic semiconducting (OSC) compounds containing one or more 1,3-dithiolo[5,6-f]benzo-2,1,3-thiadiazole (“DTBTz”) or 1,3-dithiolo[6,7-g]quinoxaline (“DTQ”) units or derivatives thereof, to methods for their preparation and educts or intermediates used therein, to compositions and formulations containing them, to the use of the compounds and compositions as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices, perovskite-based solar cell (PSC) devices, organic photodetectors (OPD), organic field effect transistors (OFET) and organic light emitting diodes (OLED), and to OE devices comprising these compounds or compositions.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 20, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Changsheng WANG, William MITCHELL
  • DEUTERATED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
    Publication number: 20190185508
    Abstract: The present invention is directed to deuterated 4?-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 20, 2019
    Applicants: Merck Sharp & Dohme Corp., Idenix Pharmaceuticals LLC
    Inventors: Francois-Rene Alexandre, Izzat Raheem
  • Semiconducting particles in electronic elements
    Publication number: 20190189698
    Abstract: The present invention relates inter alia to a color display comprising nanoparticles and color filters.
    Type: Application
    Filed: February 14, 2019
    Publication date: June 20, 2019
    Applicants: MERCK PATENT GMBH, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Bernhard RIEGER, Edgar BOEHM, Volker HILARIUS, Christof PFLUMM, Uri BANIN
  • CHROMANE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR THE TREATMENT OF VIRAL DISEASES
    Publication number: 20190185486
    Abstract: The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A?, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
    Type: Application
    Filed: August 14, 2017
    Publication date: June 20, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Wensheng Yu, Joseph A. Kozlowski, Ling Tong, Craig A. Cobum, Bin Hu, Bin Zhong, Jinglai Hao, Dahai Wang
  • LIQUID-CRYSTAL MEDIUM
    Publication number: 20190185748
    Abstract: The present invention relates to an LC medium comprising and a liquid-crystalline host consisting of an LC component H) comprising one or more mesogenic or liquid-crystalline compounds and an optically active component D) and optionally a polymerizable component P) comprising one or more polymerizable compounds; and to the use of the polymerizable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment type.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicant: MERCK PATENT GMBH
    Inventor: Kirsten (Min-Chu) LIAO
  • Liquid-crystalline medium and high-frequency components comprising same
    Patent number: 10323188
    Abstract: The present invention relates to liquid-crystalline media comprising one or more pleochroic dyes and one or more compounds selected from the group of compounds of formulae I, II and III, in which the parameters have the meaning indicated in Claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: June 18, 2019
    Assignee: Merck Patent GmbH
    Inventors: Michael Wittek, Dagmar Klass, Peer Kirsch
  • F-saccharide-folates
    Patent number: 10322195
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the 18F isotope F is linked via a prosthetic group, more specifically via a prosthetic group having a saccharide group, such as a cyclic mono- or oligosaccharide, preferably based on a pyranoside or furanoside, which is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: June 18, 2019
    Assignee: Merck & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Simon Mensah Ametamey, Cindy Ramona Fischer, Viola Groehn
  • Indole derivatives and their use in neurodegenerative diseases
    Patent number: 10323000
    Abstract: The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: June 18, 2019
    Assignee: Merck Patent GmbH
    Inventor: Srinivasa R. Karra
  • Antibody neutralizing human respiratory syncytial virus
    Patent number: 10323079
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 18, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su