Patents Assigned to Merck
  • Cold Storage System for Storing Pharmaceutical Product Containers
    Publication number: 20190114731
    Abstract: Intelligent refrigerator system for storing pharmaceutical product containers, such as vials, ampules, syringes, bottles, medication tubes, blister packs and cartons, at the point of dispensing. Embodiments of the invention use product identification technology, such as radio-frequency identification (RFID) tags and readers, to uniquely identify containers as they are added to or removed from the cold storage compartment of the refrigerator, and automatically retrieve from a local or remote database a variety of details associated with the containers and their contents, such as manufacturing data, expiration dates, time out of refrigeration, inventory levels, safety information, usage statistics, known contraindications and warnings, etc. If the details indicate that there is a problem with a particular pharmaceutical (e.g.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 18, 2019
    Applicant: Merck, Sharp & Dohme Corp
    Inventor: Alan J. Lowenstein
  • PARTICLE SIZE AND DISTRIBUTION OF POLYMER FOR MELT EXTRUSION APPLICATION
    Publication number: 20190111138
    Abstract: The present invention relates to an improved powdered polyvinyl alcohol (PVA), which can be used for pharmaceutical products, and that due to its improved properties can be better dosed during formulation processes.
    Type: Application
    Filed: May 10, 2017
    Publication date: April 18, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter LUBDA, Mengyao ZHENG, Nicole DI GALLO, Anja-Nadine KNUETTEL
  • Liquid crystal material
    Patent number: 10260001
    Abstract: The present application relates to a liquid-crystalline material which comprises at least one dye compound and at least one compound of a formula (IA) or (IB). The liquid-crystalline material is suitable for use in optical switching devices, in particular in devices for the homogeneous regulation of the passage of light through an area.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: April 16, 2019
    Assignee: Merck Patent GmbH
    Inventors: Michael Junge, Mila Fischer, Ursula Patwal, Peer Kirsch, Susann Beck
  • Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
    Patent number: 10259795
    Abstract: The invention provides ?-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1?-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: April 16, 2019
    Assignee: Merck Serono S.A.
    Inventors: Patrick Naxos Page, Matthias Schwarz, Catherine Jorand-Lebrun, Anna Quattropani, Vincent Pomel
  • Proof of non-tampering for stored data
    Patent number: 10261711
    Abstract: An application shim receives transactions that will update a portion of data stored in an existing data store. A reduced representation of the pre-update portion of data is generated and compared to an existing reduced representation of the same portion of data to verify that the data has not been tampered with. An updated reduced representation is generated based on the post-update portion of data. The updated reduced representation is added to a distributed ledger such as a block chain. Further verification of non-tampering may be provided by comparing the reduced representation stored by the system and the one appended to the blockchain. If a discrepancy is identified, appropriate corrective action may be taken, such as blocking further transactions, notifying responsible entities, and/or restoring the data from a backup.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: April 16, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: David Brett Pasirstein
  • COMPOSITIONS COMPRISING FUNCTIONALIZED POLYVINYL ALCOHOL AND NANOCAPSULES CONTAINING A LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20190106627
    Abstract: The use of functionalized polymerizable polyvinyl alcohol as a binder or matrix for a dispersion of nanoparticles, wherein the nanoparticles respectively comprise a polymeric shell and a core containing a liquid crystalline medium. Composites comprising the functionalized polymer and the nanocapsules, methods for preparing the composites and electro-optical devices containing such composites.
    Type: Application
    Filed: October 5, 2018
    Publication date: April 11, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Hassan ARASI, Mariam NAMUTEBI, Rachel TUFFIN
  • COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES
    Publication number: 20190106391
    Abstract: The present invention describes spirobifluorene derivatives substituted by pyridine and/or pyrimidine groups, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
    Type: Application
    Filed: March 15, 2017
    Publication date: April 11, 2019
    Applicant: Merck Patent GmbH
    Inventors: Margarita Wucherer-Plietker, Amir Parham, Sebastian Meyer, Tobias Grossmann
  • NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
    Publication number: 20190106431
    Abstract: The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • CMV NEUTRALIZING ANTIGEN BINDING PROTEINS
    Publication number: 20190106481
    Abstract: A supercritical extractor system may include extractor chambers coupled to a supercritical fluid pump and configured to receive a matrix for an extraction process and a supercritical fluid from the supercritical fluid pump, and evaporator chambers coupled to the extractor chambers and configured to output an extractant from the matrix. Each evaporator chamber may include a body defining a cavity, a cone within the cavity, and arms coupled between an inner surface of the body and the cone. The supercritical extractor system may include a condenser coupled between the evaporator chambers and the supercritical fluid reservoir, and a controller coupled to the supercritical fluid pump, the extractor chambers, and the evaporator chambers and configured to monitor a characteristic during the extraction process.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 11, 2019
    Applicants: Merck Sharp & Dohme Corp., The Board of Regents, The University of Texas System
    Inventors: Tong-Ming Fu, Aimin Tang, Dai Wang, Zhiqiang An, Ningyan Zhang, Sha Ha
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20190106626
    Abstract: The invention relates to a liquid crystalline medium, characterised in that it comprises one or more compounds of formula A and one or more compounds of formula II wherein the parameters have the meaning indicated in claim 1, and to high-frequency components comprising the same, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, in particular microwave phased-array antennas.
    Type: Application
    Filed: March 22, 2017
    Publication date: April 11, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Constanze BROCKE, Atsutaka MANABE, Michael WITTEK, Renate SEEGER
  • Composition and method for preparation of organic electronic devices
    Patent number: 10256408
    Abstract: The present invention relates to novel compositions comprising an organic semiconductor (OSC) and one or more organic solvents. The composition is solid at a temperature of 25° C. and fluid at a higher temperature and the boiling point of the solvent is at most 400° C. Furthermore, the present invention describes the use of these compositions as inks for the preparation of organic electronic (OE) devices, especially organic photovoltaic (OPV) cells and OLED devices, to methods for preparing OE devices using the novel compositions, and to OE devices, OLED devices and OPV cells prepared from such methods and compositions.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: April 9, 2019
    Assignee: Merck Patent GmbH
    Inventors: Mark James, Magda Goncalves-Miskiewicz, Philip E. May, Lana Nanson, Ruth Effenberger, Edgar Kluge
  • Magnetic pigments
    Patent number: 10253191
    Abstract: The present invention is related to magnetic pigments comprising a transparent flaky homogeneously composed substrate having two parallel major surfaces and a coating comprising a layered structure composed of a hematite and a magnetite layer, to a process for the production of said pigments as well as to their use.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: April 9, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Kaiman Shimizu, Fumiko Sasaki, Yukitaka Watanabe, Masahiko Yazawa
  • Diazirine containing organic electronic compositions and device thereof
    Patent number: 10256409
    Abstract: The present invention relates to organic electronic devices, and more specifically to organic field effect transistors, comprising a dielectric layer that comprises a polycycloolefinic polymer and a diazirine compound.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 9, 2019
    Assignees: PROMERUS, LLC, MERCK PATENT GMBH
    Inventors: Larry F Rhodes, Hugh Burgoon, Irina Afonina, Tomas Backlund, Aurelie Morley
  • Receptacle for accepting nutrient media
    Patent number: 10253288
    Abstract: Disclosed is a receptacle for accepting nutrient media, especially for bacterial cultures. Said receptacle comprises a dish and a lid that covers the dish. The dish and the lid each have a circular bottom (dish bottom and lid bottom) and an annular wall (dish wall and lid wall) that projects from the bottom. One of the walls, preferably the lid wall, has an at least slightly larger internal diameter than the external diameter of the other wall, preferably the dish wall, such that one wall can be slid onto the other wall to close the dish. In order to be able to safely handle the receptacle, engaging means which prevent the dish and the lid from being accidentally released when the same are mutually engaged, are associated with the dish and the lid.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: April 9, 2019
    Assignee: MERCK PATENT GMBH
    Inventor: Rolf Müller
  • Boronic acid derivatives
    Patent number: 10253049
    Abstract: Compounds of formula (I) are inhibitors of LMP7 and can be employed, inter alia, for the treatment of an autoimmune disorder or hematological malignancies.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 9, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Markus Klein, Oliver Schadt, Philipp Haselmayer, Michael Busch
  • Heteroaryl compounds as BTK inhibitors and uses thereof
    Patent number: 10253023
    Abstract: The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: April 9, 2019
    Assignee: Merck Patent GmbH
    Inventors: Pascale Gaillard, Jeyaprakashnarayanan Seenisamy, Lesley Liu-Bujalski, Richard D. Caldwell, Justin Potnick, Hui Qiu, Constantin Neagu, Reinaldo Jones, Annie Cho Won, Andreas Goutopoulos, Brian A. Sherer, Theresa L. Johnson, Anna Gardberg
  • Process for making nucleoside phosphoramidate compounds
    Patent number: 10251903
    Abstract: The present invention is directed to a process for making Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: April 9, 2019
    Assignees: Merck Sharp & Dohme Corp., Idenix Pharmaceuticals LLC
    Inventors: Bryon L. Simmons, Kevin R. Campos, Artis Klapars, Alistair J. Stewart, Benjamin A. Mayes, Peter E. Maligres, Alan Hyde, Steven Mark Silverman, Yong-Li Zhong, Adel M. Moussa, Kenneth Baker, Kara Van Valkenburg
  • AMINO ACID SEQUENCES DIRECTED AGAINST IL-17A, IL-17F AND/OR IL-17A/F AND POLYPEPTIDES COMPRISING THE SAME
    Publication number: 20190100584
    Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
    Type: Application
    Filed: June 7, 2018
    Publication date: April 4, 2019
    Applicant: Merck Patent GmbH
    Inventors: Heidi ROMMELAERE, Joost Alexander KOLKMAN, Michael John Scott SAUNDERS, Ann UNION, Yolande CHVATCHKO, Amanda E.I. PROUDFOOT, Alain VICARI, Denis BRUNIQUEL, Laurent CHEVALET, Olivier LEGER
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20190100695
    Abstract: The present invention relates to liquid crystal mixtures comprising one or more compounds of the formula A and, in addition one or more compounds of formula I or one or more compounds of formula II wherein the individual radicals have the respective meanings indicated in claim 1, to the use thereof for high-frequency components, and to high-frequency components, in particular antennae, especially for the gigahertz range, comprising these media.
    Type: Application
    Filed: March 22, 2017
    Publication date: April 4, 2019
    Applicant: Merck Patent GmbH
    Inventors: Atsutaka MANABE, Christian JASPER, Volker REIFFENRATH, Constanze BROCKE, Detlef PAULUTH, Dagmar KLASS, Renate SEEGER
  • CHEWABLE DOSAGE FORMS CONTAINING SITAGLIPTIN AND METFORMIN
    Publication number: 20190099367
    Abstract: The present invention provides a chewable dosage form having a matrix comprising: a combination of active pharmaceutical ingredients which is metformin hydrochloride and sitagliptin or a pharmaceutically acceptable salt thereof; a fully or partially pregelatinized starch, a polyethylene glycol polymer; a lubricant; an emulsifier; a flavoring agent; and a sweetener. The present invention also provides a method of treating diabetes, e.g., non-insulin dependent (Type 2) diabetes mellitus, comprising administering a therapeutically effective amount of the chewable dosage form to a mammalian patient in need thereof.
    Type: Application
    Filed: September 25, 2018
    Publication date: April 4, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Wycliffe S. Omwancha, Rubi Burlage