Patents Assigned to Merck
  • Rotary printing method
    Patent number: 10131168
    Abstract: The present invention relates to a rotary printing process for the application of functional coatings to a print substrate, to a coated print substrate produced by the said process, and to the use thereof, in particular in the packaging sector.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: November 20, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Andreas Becker, Thomas Rathschlag, Johannes Tasch
  • Amido-Substituted Pyridotriazine Derivatives Useful As HIV Integrase Inhibitors
    Publication number: 20180325927
    Abstract: The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R1, R2 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyridotriazine Derivative, and methods of using the Amido-Substituted Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.
    Type: Application
    Filed: November 11, 2016
    Publication date: November 15, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Thomas H. Graham, Tao Yu, Sherman T. Waddell, John A. McCauley, Andrew Stamford, Wengsheng Liu, Jay A. Grobler, Libo Xu
  • SAMPLE PREPARATION DEVICE
    Publication number: 20180328823
    Abstract: A sample preparation device (1) comprising a first chamber (2) containing a membrane support (30) on which a membrane (9) is placed or can be placed, an inlet (20) to the first chamber (2) and an outlet (21) from the first chamber (2), at least one second chamber (3) provided with or adapted to be provided with an anaerobic generation means (23) and/or an anaerobic detection indicator, wherein the at least one second chamber (3) is connected to the first chamber (2) by a communication path (8), wherein the communication path (8) is liquid-tightly closed by a tap device (4) in a first position (A) of the tap device (4) and is adapted to be opened to allow fluid communication between the first chamber (2) and the at least one second chamber (3) in that the tap device (4) is moved to a second position (B) of the tap device (4).
    Type: Application
    Filed: October 13, 2016
    Publication date: November 15, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Stephane OLIVIER, Fabrice COMINI
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20180327667
    Abstract: The invention relates to a liquid-crystalline medium, characterised in that it comprises one or more compounds of the formula IA, and one or more compounds of the formula IB, in which RA, RB, XA, XB and Y1-13 have the meanings indicated in Claim 1, and to the use thereof for electro-optical purposes, in particular for shutter glasses, 3D applications, in TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, PS-FFS and PS-VA-IPS displays.
    Type: Application
    Filed: July 25, 2018
    Publication date: November 15, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Harald HIRSCHMANN, Sabine SCHOEN
  • AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
    Publication number: 20180327385
    Abstract: Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein “R1”, “RA-1”, “R2”, “R3”, and “Het” are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
    Type: Application
    Filed: November 13, 2015
    Publication date: November 15, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Rongze KUANG, Pauline Ting, Amjad Ali, Heping Wu, Michael Berlin, Andrew Stamford, Hongwu Wang, Gang Zhou, David Kim, Qiaolin Deng, Yeon-Hee Lim, Younong Yu
  • IMPROVED PROTEIN SEPARATION IN ION EXCHANGE CHROMATOGRAPHY
    Publication number: 20180327447
    Abstract: Disclosed are improved preparative (>5 g/l) protein separations, which are achieved by combining salt and pH gradients for preparative protein separations in combination with the development of a preparative step elution protein separation based on data generated by combined salt-pH gradient runs.
    Type: Application
    Filed: October 28, 2016
    Publication date: November 15, 2018
    Applicant: Merck Patent GmbH
    Inventor: Matthias JOEHNCK
  • BI-SPECIFIC ANTIBODIES FOR ENHANCED TUMOR SELECTIVITY AND INHIBITION AND USES THEREOF
    Publication number: 20180326085
    Abstract: A heterodimeric bispecific immunoglobulin molecule includes a first Fab or scFv fragment which specifically binds to EGFR, and a second Fab or scFv fragment which specifically binds to c-MET, and an antibody hinge region, an antibody CH2 domain and an antibody CH3 domain including a hybrid protein-protein interaction interface domain. Each of the interaction interface domains is formed by an amino acid segment of the CH3 domain of a first member and an amino acid segment of the CH3 domain of a second member. The hybrid protein-protein interface domain of the first chain is interacting with the protein-protein-interface of the second chain by homodimerization of a corresponding amino acid segment of the same member of the immunoglobulin superfamily within interaction domains.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 15, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Achim DOERNER, Lars TOLEIKIS, SOOD D. Vanita, Carolin SELLMANN, Christine KNUEHL
  • SYSTEM AND METHODS FOR DERIVING GENE SIGNATURE BIOMARKERS OF RESPONSE TO PD-1 ANTAGONISTS
    Publication number: 20180327848
    Abstract: A gene expression platform, which is a combination of a set of genes that are correlated with response to a PD-1 antagonist in multiple tumor types and a normalization gene set, is disclosed. A method and system of using the gene expression platform to derive gene signature biomarkers of anti-tumor response to a PD-1 antagonist and to test patient samples for predictive gene signature biomarkers are also disclosed.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 15, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Mark D. Ayers, Andrey Loboda, Jared K. Lunceford, Terrill K. McClanahan, Erin E. Murphy, Michael Nebozhyn
  • Cyanopyridine Derivatives as Liver X Receptor Beta Agonists, Compositions, and Their Use
    Publication number: 20180327374
    Abstract: In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Application
    Filed: November 7, 2016
    Publication date: November 15, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Michael T. Rudd, Edward J. Brnardic, Yuntae Kim, Robert S. Meissner, Vanessa L. Rada, Shawn J. Stachel, Celina V. Zerbinatti
  • Spirocyclic Pyridotriazine Derivatives Useful As HIV Integrase Inhibitors
    Publication number: 20180325926
    Abstract: The present invention relates to Spirocyclic Pyridotriazine Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R16 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Pyridotriazine Derivative, and methods of using the Spirocyclic Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.
    Type: Application
    Filed: November 11, 2016
    Publication date: November 15, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Thomas H. Graham, Tao Yu, Sherman T. Waddell, John A. McCauley, Andrew Stamford, Wengsheng Liu, Jay A. Grobler, Libo Xu
  • METERING INJECTOR FOR DELIVERNG LIQUID, AND METHOD OF USING SAME
    Publication number: 20180326157
    Abstract: An injector for delivering liquid can include a body having a proximal end, a distal end, a longitudinal axis, and a track follower adjacent to the proximal end. A plunger can be disposed at least partially within the body and movable with respect to the body along the longitudinal axis. An actuator can be positioned at the proximal end of the body and operably connected to the plunger. The actuator can include a track having a first portion and a second portion. The first portion can limit travel of the actuator along the longitudinal axis to deliver a first predetermined amount of the liquid. The second portion can limit travel of the actuator along the longitudinal axis to deliver a second predetermined amount of the liquid. The actuator can be positionable to selectively control displacement of the plunger pursuant to the first portion or the second portion of the track.
    Type: Application
    Filed: December 14, 2016
    Publication date: November 15, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jeffrey C. Givand, Peter A. Basile
  • COMPOUNDS FOR ELECTRONIC DEVICES
    Publication number: 20180327339
    Abstract: The present application relates to phenanthrene compounds of a particular formula (I), their use in electronic devices, electronic devices comprising such phenanthrene compounds, as well as processes for the synthesis of such phenanthrene compounds.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 15, 2018
    Applicant: Merck Patent GmbH
    Inventors: Lara-Isabel Rodriguez, Rouven Linge, Sebastian Meyer, Holger Heil
  • Polarized light emissive device
    Patent number: 10126475
    Abstract: The present invention relates to a polarized light emissive device comprising a plural of fluorescent semiconductor quantum rods, and to a preparation thereof. The invention further relates to a use of the polarized light emissive device in optical devices, and to an optical device comprising the polarized light emissive device.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: November 13, 2018
    Assignee: Merck Patent GmbH
    Inventor: Masaki Hasegawa
  • Phosphors and phosphor-converted LEDs
    Patent number: 10125315
    Abstract: The present invention relates to pyrosilicate phosphors, to a process for the preparation thereof and to the use thereof as conversion phosphors. The present invention also relates to an emission-converting material comprising the conversion phosphor according to the invention, and to the use thereof in light sources, in particular pc-LEDs (phosphor converted light emitting devices). The present invention furthermore relates to light sources, in particular pc-LEDs, and to lighting units which comprise a primary light source and the emission-converting material according to the invention.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: November 13, 2018
    Assignee: Merck Patent GmbH
    Inventors: Aleksander Zych, Ralf Petry, Mathias Rapphahn, Ingo Koehler, Stefan Tews
  • Synthesis of cephalosporin compounds
    Patent number: 10125149
    Abstract: Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: November 13, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: David Waller, Gregory Gazda, Zachary Minden, Lisa Barton, Clifton Leigh
  • Method for preparing crystalline insulin or insulin analog compositions
    Patent number: 10124040
    Abstract: A method for crystallizing insulin or insulin analogs under alkaline conditions in the presence of zinc, purifying the crystals by filtering through a filter, and drying the crystals captured on the filter to produce crystalline insulin or insulin analog compositions is described. Method has been exemplified with insulin lispro.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: November 13, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Douglas S. Watson, Allison C. Ortigosa, Mark C. Sleevi, Kathryn M. Story
  • Factor XIa inhibitors
    Patent number: 10123995
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: November 13, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Eric Mertz, Weiguo Liu, Scott D. Edmondson, Amjad Ali, Ying-Duo Gao, Santhosh F. Neelamkavil, Sung-Sau So, Remond Moningka, Wanying Sun, Alan Hruza, Linda L. Brockunier
  • Particles for electrophoretic displays comprising a core and a random-copolymer coating
    Patent number: 10126625
    Abstract: This invention relates to particles comprising a core particle and a polymeric shell, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: November 13, 2018
    Assignee: Merck Patent GmbH
    Inventors: Nils Greinert, Thomas Bauer, Matthias Koch, Wolfgang Hechler, Thomas Rentschler, Nathan Smith
  • Materials for electronic devices
    Patent number: 10125214
    Abstract: The present invention relates to polymers comprising structural units having partially fluorinated substituents, to mixtures and formulations comprising the polymers according to the invention, to a process for the preparation of the polymers according to the invention, and to the use of the polymers according to the invention as functional materials in electronic devices.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: November 13, 2018
    Assignee: Merck Patent GmbH
    Inventors: René Peter Scheurich, Junyou Pan, Frank Egon Meyer, Niels Schulte, Rémi Manouk Anèmian, Susanne Heun, Thomas Eberle, Aurélie Ludemann, Herwig Buchholz, Wolfgang Hierse
  • NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
    Publication number: 20180319804
    Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I).
    Type: Application
    Filed: July 11, 2018
    Publication date: November 8, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jongwon Lim, Xianhai Huang, Ronald D. Ferguson, Wei Zhou, Christopher W. Boyce, Phieng Siliphaivanh, David J. Witter, Milana M. Maletic, Joseph A. Kozlowski, Kevin J. Wilson