Patents Assigned to Merck
  • LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT
    Publication number: 20180258346
    Abstract: The present invention relates to liquid-crystalline media (LC media) comprising a low-molecular-weight component, a self-alignment additive comprising a thiol group and optionally a polymerizable component. The self-alignment additives effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the liquid-crystalline medium (LC medium) without alignment layers. The invention discloses novel structures for self-alignment additives which have a thiol functional groups.
    Type: Application
    Filed: August 16, 2016
    Publication date: September 13, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Yong-Kuk YUN, Min-Ok JIN, Hyun-Jin YOON, Mi-Nam PARK, Rocco FORTTE, Graziano ARCHETTI, Thorsten KODEK, Izumi SAITO
  • PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180256575
    Abstract: The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: May 10, 2016
    Publication date: September 13, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dong-Ming Shen, Deping Wang, XiaoXia Qian, Bart Harper, Meng Yang, Yingjian Bo
  • 7-AMINOCEPHEM DERIVATIVE COMPOUNDS
    Publication number: 20180258101
    Abstract: This disclosure provides methods of making certain 7-aminocephem derivatives useful in the manufacture of cephalosporin antibiotic compounds.
    Type: Application
    Filed: March 14, 2018
    Publication date: September 13, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian MOSHOS, Valdas JURKAUSKAS
  • ZINC-SULFIDE PIGMENTS COATED WITH SIO2-AGGLOMERATES
    Publication number: 20180258289
    Abstract: The present invention relates to coated zinc sulfide pigments and to the use thereof, preferably in paints, automotive paints, industrial coatings, powder coatings, plastics, printing inks, ceramic glazes and cosmetic formulations, and to a process for the preparation thereof.
    Type: Application
    Filed: July 29, 2016
    Publication date: September 13, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Helge Bettina KNIESS, Ulrich QUITTMANN, Oliver Robert PIENING
  • BRØNSTED-ACIDIC FLUOROALKYL PHOSPHONATES
    Publication number: 20180258115
    Abstract: The invention relates to Brønsted-acidic fluoroalkyl phosphonates as bifunctional catalysts and to processes for the preparation thereof.
    Type: Application
    Filed: August 30, 2016
    Publication date: September 13, 2018
    Applicant: Merck Patent GmbH
    Inventors: Nikolai (Mykola) IGNATIEV, Peter BARTHEN, Bernd BREDENHAGEN, Michaela Katharina MEYER, Walter FRANK
  • OXY-CYANOQUINOLINONE PDE9 INHIBITORS
    Publication number: 20180258046
    Abstract: The present invention is directed to oxycyanoquinolinone compounds which may be useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: July 27, 2016
    Publication date: September 13, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: ANTONELLA CONVERSO, MILDRED L. KAUFMAN, KEVIN RODZINAK
  • ORGANIC SEMICONDUCTOR COMPOSITIONS AND THEIR USE IN THE PRODUCTION OF ORGANIC ELECTRONIC DEVICE
    Publication number: 20180261768
    Abstract: The present invention relates compositions comprising an organic semiconducting material, a solvent, and specifically selected polymer particles, which allow modifying the viscosity of such compositions. The present application further relates to the use of such compositions in the production of organic electronic devices.
    Type: Application
    Filed: July 11, 2016
    Publication date: September 13, 2018
    Applicant: Merck Patent GmbH
    Inventors: Lichun CHEN, Andromachi MALANDRAKI
  • Pharmaceutical Compound
    Publication number: 20180258075
    Abstract: Provided is a compound having formula (I): wherein R2 is selected from —C1, —Br and —CN; R1 and R4 are independently selected from H and —F; R631, R632, R641 and R642 are independently selected from —H, —F and substituted or unsubstituted C1-C3 alkyl groups; and R651 and R652 are independently selected from H and substituted or unsubstituted C1-C3 alkyl groups and substituted or unsubstituted phenyl groups; and wherein at least one of R631, R632, R641, R642 and R652 is not —H, or wherein when all of R631, R632, R641, R642 and R652 are —H, R651 is not Me or Et.
    Type: Application
    Filed: September 12, 2016
    Publication date: September 13, 2018
    Applicants: Merck Sharp & Dohme Corp., IOmet Pharma Ltd.
    Inventors: Phillip M. Cowley, Yongxin Han
  • PHENOXAZINE DERIVATIVES FOR ORGANIC ELECTROLUMINESCENT DEVICES
    Publication number: 20180258082
    Abstract: The present invention relates to the compounds of the formula (1) and to organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as host material or dopant in the emitting layer and/or as hole-transport material and/or as electron-transport material.
    Type: Application
    Filed: July 15, 2016
    Publication date: September 13, 2018
    Applicant: Merck Patent GmbH
    Inventors: Holger Heil, Beate Burkhart, Lara-Isabel Rodriguez, Sebastian Meyer, Rouven Linge, Amandine Darsy
  • ANTIBODY THAT BINDS TO HUMAN PROGRAMMED DEATH LIGAND 2 (PD-L2) AND USES THEREOF
    Publication number: 20180258171
    Abstract: The present disclosure provides antibodies and antigen binding fragments thereof including, but not limited to, monoclonal antibodies that specifically bind to human programmed death ligand 2 (PD-L2). The invention further provides nucleic acids encoding the antibodies and antigen binding fragments of the invention and host cells transformed therewith. The antibodies and antigen binding proteins of the invention are useful in methods for the immunohistochemical detection of human PD-L2 expression in tissue samples.
    Type: Application
    Filed: September 20, 2016
    Publication date: September 13, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jennifer H. Yearley, Linda Liang, Michael Eric Bigler, Christopher John Gibson
  • Methods of use of anti-CD19 antibodies with reduced immunogenicity
    Patent number: 10072092
    Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: September 11, 2018
    Assignee: Merck Patent GmbH
    Inventors: Michael Super, Jonathan Davis, Pascal Andre Stein
  • Antibody neutralizing human respiratory syncytial virus
    Patent number: 10072072
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: September 11, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Liquid-crystalline medium and liquid-crystal display comprising the same
    Patent number: 10072210
    Abstract: The invention relates to a liquid-crystalline medium, having particular dielectric properties, in that it has: either a dielectric constant perpendicular to the director (??) in the range of 2 or more to less 8 or less and at the same time a ratio of the dielectric constant perpendicular to the director (??) to the dielectric anisotropy (??), i.e. (??/??) of 1.0 or more or or a dielectric constant perpendicular to the director (??) of 8 or more and a dielectric anisotropy (??) of 26 or less and preferably comprises one or more compounds having a high dielectric constant perpendicular to the director (??) and a high average dielectric constant (?av.). These compounds are suitable for use in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: September 11, 2018
    Assignee: MERCK PATENT GMBH
    Inventor: Atsutaka Manabe
  • Compounds for electronic devices
    Patent number: 10074807
    Abstract: The present invention relates to compounds of the formula (1), to the use thereof in electronic devices, and to electronic devices, particularly organic electroluminescence devices, comprising said compounds according to the invention, particularly as blue emitting material in an emitting layer.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: September 11, 2018
    Assignee: Merck Patent GmbH
    Inventors: Arne Buesing, Holger Heil, Philipp Stoessel
  • Liquid-crystalline media
    Patent number: 10072209
    Abstract: The invention relates to liquid-crystalline media which can be used, in particular, for electro-optical displays having active-matrix addressing based on the ECB effect and for IPS (in-plane switching) displays or FFS (fringe field switching) displays.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 11, 2018
    Assignee: Merck Patent GmbH
    Inventors: Melanie Klasen-Memmer, Marcus Reuter, Rocco Fortte, Detlef Pauluth, Matthias Bremer, Helmut Haensel, Harald Hirschmann
  • Ethyl N-boc piperidinyl pyrazolo pyridones as Janus kinase inhibitors
    Patent number: 10072025
    Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: September 11, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Mark E. Scott, David Guerin, Danielle Molinari, Sam Kattar, Peter Fuller, Christopher Dinsmore, Norman Kong, Yunfeng Bai, Jianmin Fu, Yumei Liu, Zhixiang Zheng
  • Use of cyclohexanol derivatives as antimicrobial active compounds
    Patent number: 10071037
    Abstract: The present invention relates to the use of at least one cyclohexanol derivative of the formula (I) and/or (II) as antimicrobial active compound or as anti-acne, antidandruff, antiperspirant or deodorant active compound, to preparations comprising these compounds, and to specific cyclohexanol derivatives and to a process for the preparation thereof.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: September 11, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Thomas Rudolph, Tatjana Mueller
  • PROCESS FOR PREPARING SPRAY DRIED SOLID DISPERSIONS OF (S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3-(METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE FOR PHARMACEUTICAL PREPARATIONS
    Publication number: 20180250232
    Abstract: A process for preparing spray dried solid dispersions of (S)—N-(3-(6-isopropoxypyridin-3-yl)-1H4ndazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous free base and hypromellose acetate succinate for pharmaceutical preparations including pharmaceutical capsule preparations.
    Type: Application
    Filed: August 29, 2016
    Publication date: September 6, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Yung-Chi Lee, Dan Zhang
  • TABLETS HAVING MEDIA INDEPENDENT ACTIVE SUBSTANCE DELIVERY
    Publication number: 20180250233
    Abstract: The present invention relates to formulations having extended release of active ingredient, comprising an active ingredient from BCS Class I having high solubility and high permeability in a polyvinyl alcohol-containing matrix, from which the active ingredient is released at a controlled rate over a therapeutically relevant time period independently of the composition of the release medium.
    Type: Application
    Filed: August 25, 2016
    Publication date: September 6, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Finn BAUER, Thorsten WEDEL, Gudrun BIRK, Roberto OGNIBENE, Dieter LUBDA, Guenter MODDELMOG
  • METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF
    Publication number: 20180251428
    Abstract: The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound and subsequent cyclization.
    Type: Application
    Filed: August 10, 2016
    Publication date: September 6, 2018
    Applicant: Merck Patent GmbH
    Inventors: Luc EBERHARDT, Andreas WAECHTLER, David MAILLARD, Stefan LEHMANN