Patents Assigned to Merck
  • COMPOUNDS AND LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20180216005
    Abstract: Compounds of the formula I, and liquid-crystalline media, preferably having a nematic phase and negative dielectric anisotropy, comprising a) one or more compounds of the formula I and one or more compounds selected from b) one or more compounds of formula II and/or c) one or more compounds selected from compounds of formulae III-1 to III-4 and formula B Methods for making and using these liquid-crystalline media in electro-optical displays, particularly in active-matrix displays based on the VA, ECB, PALC, FFS or IPS effect and the displays which contain these media. Methods for stabilizing liquid-crystalline media with compounds of formula I, where the liquid-crystalline media comprise one or more compounds of the formula II and one or more compounds selected from compounds of the formulae III-1 to III-4 and formula B.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Martin ENGEL, Sabrina MAAG, Ingo ALMEROTH, Rocco FORTTE, Achim GOETZ, Thorsten KODEK, Oliver HEPPERT
  • COMPOUNDS AND LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20180216006
    Abstract: Compounds of formula I, and liquid-crystalline media, preferably having a nematic phase and negative dielectric anisotropy, comprising: a) one or more compounds of formula I and one or more other compounds selected from: b) one or more compounds of formula II and/or c) one or more compounds selected from compounds of formulae III-1 to III-4 and B Use thereof in electro-optical displays, particularly in active-matrix displays based on the VA, ECB, PALC, FFS or IPS effect and use of compounds of formula I for stabilisation of liquid-crystalline media which comprise one or more compounds of formula II and/or one or more compounds selected from compounds of formulae III-1 to III-4 and B.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Applicant: Merck Patent GmbH
    Inventors: Martin ENGEL, Sabrina MAAG, Ingo ALMEROTH, Rocco FORTTE, Achim GOETZ, Thorsten KODEK, Oliver HEPPERT
  • Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds
    Patent number: 10035774
    Abstract: Pyrazolyl carboxylic acid and pyrazolyl urea derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: July 31, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Yisheng Yang, Youchu Wang
  • Crystalline forms of a BACE inhibitor, compositions, and their use
    Patent number: 10035796
    Abstract: The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease, are disclosed herein.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: July 31, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Irina Kazakevich, Scott Trzaska, Tao Feng
  • LIQUID CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT
    Publication number: 20180208848
    Abstract: The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerisable component. The polymerisable component comprises self-aligning, polymerisable mesogens (polymerisable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the LC medium without alignment layers. The invention discloses novel structures for polymerisable self-alignment additives which have a certain position of the functional groups.
    Type: Application
    Filed: June 25, 2015
    Publication date: July 26, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Graziano ARCHETTI, Izumi SAITO, Rocco FORTTE, Oliver HEPPERT, Andreas TAUGERBECK, Elena NEUMANN
  • COMPOSITIONS OF FLUORINATED SURFACTANTS AND ANTIOXIDANTS
    Publication number: 20180207080
    Abstract: The invention relates to the use of specific fluorosurfactants for increasing the efficacy of antioxidants, in particular in cosmetic, dermatological preparations and medicinal products, and to specific mixtures and preparations
    Type: Application
    Filed: June 16, 2016
    Publication date: July 26, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Manuela LOCH, Reiner FRIEDRICH
  • PULVERULENT, DIRECTLY COMPRESSIBLE POLYVINYL ALCOHOL GRADES
    Publication number: 20180207101
    Abstract: The present invention relates to premixes for the production of active compound-containing tablets which comprise polyvinyl alcohols (PVAs). The invention also relates to active compound-containing tablets which comprise a corresponding premix.
    Type: Application
    Filed: July 3, 2015
    Publication date: July 26, 2018
    Applicant: Merck Patent GmbH
    Inventors: Roberto OGNIBENE, Finn BAUER, Thorsten WEDEL, Guenter MODDELMOG
  • MODULATION OF TUMOR IMMUNITY
    Publication number: 20180207266
    Abstract: Methods of treating proliferative disorders are described. In particular, combination treatment with a GITR agonist and a PD-1 antagonist are provided.
    Type: Application
    Filed: March 20, 2018
    Publication date: July 26, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Gu Danling, Amy M. Beebe
  • ASSAY FOR SIMULTANEOUS GENOMIC AND PROTEOMIC ANALYSIS
    Publication number: 20180208975
    Abstract: The present invention is directed to a biochemical assay for simultaneous genomic and proteomic analysis.
    Type: Application
    Filed: January 17, 2018
    Publication date: July 26, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Vanessa Marie Peterson, Joel Albert Klappenbach
  • PHENYL-CYANOQUINOLINONE PDE9 INHIBITORS
    Publication number: 20180208557
    Abstract: The present invention is directed to phenylcyanoquinolinone compounds which may be useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: July 27, 2016
    Publication date: July 26, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: VICTORIA COFRE, ANTONELLA CONVERSO, KEVIN RODZINAK
  • DEVICE FOR THE REGULATION OF LIGHT TRANSMISSION
    Publication number: 20180210272
    Abstract: The present application concerns a switchable device for the regulation of light transmission, which has a compartemented structure, where the switching state of each of the compartments can be controlled individually.
    Type: Application
    Filed: June 20, 2016
    Publication date: July 26, 2018
    Applicant: MERCK PATENT GMBH
    Inventor: Casper Laurens VAN OOSTEN
  • Heteroaryl compounds as IRAK inhibitors and uses thereof
    Patent number: 10030013
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Catherine Jorand-Lebrun, Reinaldo Jones, Annie Cho Won, Ngan Nguyen, Theresa L. Johnson, Lizbeth Celeste Deselm, Kausik Panda
  • Compounds for organic electroluminescent devices
    Patent number: 10032992
    Abstract: The present invention relates to boron compounds for use in electronic devices, especially organic electroluminescent devices, and to a process for preparing these compounds and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Amir Hossain Parham, Philipp Stoessel, Christof Pflumm, Arne Buesing, Thomas Eberle
  • Soluble guanylate cyclase stimulators
    Patent number: 10030027
    Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: July 24, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Raphaelle Berger, Yi-Heng Chen, Guoqing Li, Joie Garfunkle, Hong-Dong Li, Shouwu Miao, Subharekha Raghavan, Cameron J. Smith, John Stelmach, Alan Whitehead, Rui Zhang, Yong Zhang, Jianmin Fu, Gang Ji, Falong Jiang
  • Spirobifluorene derivative-based materials for electronic devices
    Patent number: 10032989
    Abstract: The present application relates to spirobifluorene derivatives of a formula (I), to the use thereof in electronic devices, and to processes for preparing said derivatives.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Jochen Pfister, Teresa Mujica-Fernaud, Elvira Montenegro
  • Fail safe mechanism for switchable window
    Patent number: 10031356
    Abstract: An optical device, having an active matrix, containing polymer dispersed liquid crystals, guest-host liquid crystals, suspended particles and/or polymer stabilized cholesteric liquid crystals, the active high transmissive mode has at least 40% of incoming light transmitted through the optical device and in low transmissive mode less than 40% of incoming light transmitted through the optical device, the active matrix is switchable between high transmissive mode and low transmissive mode. The optical device containing a fail-safe mechanism, which is capable to switch the active matrix from a low transmissive mode in a high transmissive mode without the power of an applied grid. The optical device has a fail-safe mechanism comprising at least one battery and a controller.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Casper Van Oosten, Felix Schlosser
  • Cell culture media
    Patent number: 10030225
    Abstract: The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. with a phosphorylated derivative.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Joerg Von Hagen, Marcel Andre Breuning, Christian Jasper
  • Methods for treating intrapulmonary infections
    Patent number: 10028963
    Abstract: This disclosure relates to the treatment of intrapulmonary bacterial infections, including treatment of nosocomial pneumonia lung infections with pharmaceutical compositions containing the cephalosporin ceftolozane.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: July 24, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Gurudatt A. Chandorkar, Jennifer A. Huntington, Tara Parsons, Obiamiwe C. Umeh
  • Electron transfer composition for use in an electron injection layer for organic electronic devices
    Patent number: 10032983
    Abstract: The present invention relates to a novel electron transfer composition comprising one or more metal ion comprising compound, the use of such electron transfer composition in organic electronic devices, particularly in photodiodes, as well as such organic electronic devices, particularly photodiodes.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: July 24, 2018
    Assignee: Merck Patent GmbH
    Inventors: Lichun Chen, Frank Egon Meyer, Andromachi Malandraki, Piotr Wierzchowiec, Tomas Backlund
  • CELL LINE 3M
    Publication number: 20180201683
    Abstract: The present invention provides, inter alia, an isolated cell line, 3M as well as methods for making such a cell line and methods of using such a cell line, e.g., to produce a protein such as an immunoglobulin.
    Type: Application
    Filed: March 6, 2018
    Publication date: July 19, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Ankit A. Merchant, Yung-Shyeng Tsao