Patents Assigned to Merck
  • AZACARBAZOLE BTK INHIBITORS
    Publication number: 20180141962
    Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In Cparticular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated dis orders.
    Type: Application
    Filed: April 4, 2016
    Publication date: May 24, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: JIAN LIU, JOSEPH KOZLOWSKI, RONALD KIM, XIAOLEI GAO, SOBHANA BABU BOGA, YOUNONG YU, HAO WU, SHILAN LIU, CHUNDAO YANG
  • BICYCLIC HETEROCYCLIC COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180141952
    Abstract: The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: June 27, 2016
    Publication date: May 24, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Shawn J. Stachel, Michael P. Dwyer, Christopher J. Sinz, Jonathan E. Wilson, Daniel V. Paone, Yili Chen, Shimin Xu
  • SURFACE ANCHORED LIGHT CHAIN BAIT ANTIBODY DISPLAY SYSTEM
    Publication number: 20180142233
    Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 24, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Hussam Hisham Shaheen, Dongxing Zha
  • THIADIAZOLOQUINOXALINE DERIVATIVES
    Publication number: 20180142153
    Abstract: The present invention relates to thiadiazoloquinoxaline derivatives of the formula I, in which R11, R12, A11, A12, A21, A22, Z11, Z12, Z21, Z22, W, X11, X12, r and s have the meanings indicated in claim 1, to processes and intermediates for the preparation thereof, to the use of the compounds of the formula I for optical, electro-optical and electronic purposes, in particular in liquid-crystal media and in devices for regulating the passage of energy from an outside space into an inside space, and to these LC media and the devices comprising these media.
    Type: Application
    Filed: April 13, 2016
    Publication date: May 24, 2018
    Applicant: Merck Patent GmbH
    Inventors: Peer KIRSCH, Andreas RUHL, Susann GUNST, Michael JUNGE, Ursula PATWAL, Mila FISCHER
  • Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta
    Publication number: 20180141947
    Abstract: The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
    Type: Application
    Filed: June 24, 2016
    Publication date: May 24, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Meredith Ann McGowan, Hua Zhou, Jason D. Katz, Lihu Yang, Joey L. Methot, Kathryn Ann Lipford, Shimin Xu, Ning Fu, Guoquan Xu, Deqian Bian, Jianmin Fu, Yabin Li, Kin Chiu Fong
  • COMPOUNDS FOR THE HOMEOTROPIC ALIGNMENT OF LIQUID-CRYSTALLINE MEDIA
    Publication number: 20180142152
    Abstract: Disclosed are liquid-crystalline media (LC media) comprising a low-molecular-weight component and a polymerisable component. The polymerisable component contains self-aligning, polymerisable mesogens (polymerisable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). Disclosed are also LC displays having homeotropic alignment of the LC medium without alignment layers. Further disclosed are the structures for polymerisable self-alignment additives.
    Type: Application
    Filed: November 20, 2017
    Publication date: May 24, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Graziano ARCHETTI, Edward PLUMMER, Helmut HAENSEL, Rocco FORTTE, Timo UEBEL
  • Purification of immunoglobulins from plasma
    Patent number: 9975920
    Abstract: The present invention relates to the purification of target molecules like immunoglobulins from plasma. The use of a certain type of ion exchanger based on a crosslinked polyvinylether results in especially high yields of the target molecule.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: May 22, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Annika Aldinger, Achim Schwaemmle, Matthias Joehnck, Dirk Mueller, Marc Mazur
  • Compounds for the inhibition of cyclophilins and uses thereof
    Patent number: 9975902
    Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: May 22, 2018
    Assignee: Merck Patent GmbH
    Inventors: Catherine Jorand-Lebrun, Theresa L. Johnson, Ulrich Graedler, Xuliang Jiang, Santosh Kulkarni
  • Organic electronic compositions and device thereof
    Patent number: 9978944
    Abstract: The present invention relates to organic electronic devices, and more specifically to organic field effect transistors, comprising a dielectric layer that comprises a polycycloolefinic polymer with an olefinic side chain.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: May 22, 2018
    Assignees: PROMERUS, LLC, MERCK PATENT GMBH
    Inventors: Larry F Rhodes, Crystal D Cyrus, Hugh A Burgoon, Irina Afonina, Toby Cull
  • Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
    Patent number: 9975888
    Abstract: The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: May 22, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Craig A. Coburn, Milana M. Maletic, Yunfu Luo, Zhiqi Qi, Chun Sing Li, Tingting Yu
  • Materials for organic electroluminescent devices
    Patent number: 9978957
    Abstract: Triphenylene derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices, one of example of which is represented by formula I. The invention furthermore relates to a process for the preparation of the triphenylene derivatives and to electronic devices comprising the triphenylene derivatives.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 22, 2018
    Assignee: Merck Patent GmbH
    Inventors: Anja Jatsch, Rémi M. Anémian, Bernd Schröder, Arne Buesing, Philipp Stoessel, Christof Pflumm, Jonas V. Kroeber, Thomas Eberle
  • Factor XIa inhibitors
    Patent number: 9975874
    Abstract: The present invention provides a compound of Formula (I) (Formula (I)) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 22, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Eric Mertz, Scott D. Edmondson, Alan Hruza, Jiafang He, Sung-Sau So, Amjad Ali, Ying-Duo Gao
  • Materials for electronic devices
    Patent number: 9978949
    Abstract: The application relates to a compound of a formula (I) which is suitable for use as functional material in electronic devices.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: May 22, 2018
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Elvira Montenegro, Frank Voges, Jonas Valentin Kroeber, Philipp Stoessel
  • Materials for electronic devices
    Patent number: 9978950
    Abstract: The present application relates to a compound of a formula (I) which contains a spirobifluorene basic structure condensed onto a benzofuran unit. The application furthermore relates to a process for the preparation of the compound of the formula (I), and to the use of the compound of the formula (I) in an electronic device.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: May 22, 2018
    Assignee: Merck Patent GmbH
    Inventors: Jochen Pfister, Frank Voges, Elvira Montenegro, Teresa Mujica-Fernaud
  • Electrophoretic fluid
    Patent number: 9977309
    Abstract: This invention relates to electrophoretic fluids comprising a solvent, a dye, white particles, and colored particles selected from red, green, blue, magenta, cyan, yellow particles, and mixtures thereof, and electrophoretic display devices comprising such fluids.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: May 22, 2018
    Assignee: Merck Patent GmbH
    Inventor: Nathan Smith
  • Variants of group 5 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues
    Patent number: 9975932
    Abstract: The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterized by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: May 22, 2018
    Assignee: Merck Patent GmbH
    Inventors: Martin Wald, Andreas Nandy, Helmut Fiebig, Bernhard Weber, Helga Kahlert, Gerald Reese, Oliver Cromwell
  • 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists
    Patent number: 9975876
    Abstract: The present invention is directed to 2-pyridyloxy-3-ester-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ether compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: May 22, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Scott D. Kuduk, Jason W. Skudlarek
  • Method and device for carrying out thin-layer chromatography
    Patent number: 9976999
    Abstract: A method for performing thin-layer chromatography applies a liquid sample to a separating layer. A mobile phase is subsequently applied to the separating layer and brought into contact with the liquid sample. After a developmental phase, a thin-layer chromatogram is produced. The liquid sample is taken up from a sample storage container with the aid of an autopipette using a new pipette tip for each sample application operation and applied to the separating layer. A device for performing the method includes a support plate for the accommodation of the separating layer, a first storage container for the accommodation of the sample, and a second storage container for the accommodation of the mobile phase.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: May 22, 2018
    Assignee: MERCK PATENT GMBH
    Inventor: Michael Schulz
  • New stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Publication number: 20180134711
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Typeface
    Patent number: D818526
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: May 22, 2018
    Assignee: Merck KGaA
    Inventors: Richard Holt, Andrew Millington, Vinay Mistry, Stuart Dickinson