Patents Assigned to Merck
  • Ceftolozane antibiotic compositions
    Patent number: 9872906
    Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: January 23, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
  • Liquid-crystalline medium and electro-optical display
    Patent number: 9873834
    Abstract: The invention relates to a liquid-crystalline medium having a nematic phase and negative dielectric anisotropy which comprises a) one or more compounds of formula I b) one or more compounds of formula II and c) one or more compounds selected from the compounds of formulae III-1 to III-4 in which the parameters have the meanings indicated herein, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the VA, ECB, PALC, FFS or IPS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the use of the compounds of the formula I for the stabilisation of a liquid-crystalline medium which comprises one or more compounds of formula II and one or more compounds selected from the compounds of formulae III-1 to III-4.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: January 23, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Mark Goebel, Elvira Montenegro, Atsutaka Manabe
  • PROCESS FOR PRINTING MULTICOLOURED PRINTED IMAGES
    Publication number: 20180016452
    Abstract: The present invention relates to a process for printing multicoloured printed images in which exclusively interference pigments are used for the coloured pigmentation of the printing inks, to printed products produced using a process of this type, to the use thereof, and to suitable interference pigments.
    Type: Application
    Filed: January 25, 2016
    Publication date: January 18, 2018
    Applicant: Merck Patent GmbH
    Inventors: Peter CLAUTER, Cairon PLATZER, Kirsten FRITSCHE, Marc-Dieter WEINGART, Lorenz BOEGLI, Christoph SCHMIDT
  • PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS
    Publication number: 20180015106
    Abstract: The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof wherein: R1 is W is and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 18, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Zhiqiang Yang, Guizhen Dong, Milana Maletic
  • CONJUGATES FOR PROTECTION FROM NEPHROTOXIC ACTIVE SUBSTANCES
    Publication number: 20180015173
    Abstract: The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds, to a process for the preparation of the conjugate, to the use thereof for the protection of the kidney against nephrotoxic active compounds, and to a medicament comprising the conjugate.
    Type: Application
    Filed: October 3, 2017
    Publication date: January 18, 2018
    Applicant: Merck Patent GmbH
    Inventors: Armin KUEBELBECK, Gregor LARBIG, Stefan ARNOLD, Walter MIER, Uwe HABERKORN
  • LIGHT MODULATION ELEMENT
    Publication number: 20180016499
    Abstract: The invention relates to a light modulation element comprising a cholesteric liquid crystalline medium sandwiched between two substrates (1), provided with a common electrode structure (2) and a driving electrode structure (3) individually, wherein the substrate with driving and/or common electrode structure is additionally provided with an alignment electrode structure (4) which is separated from the driving and or common electrode structure on the same substrate by a dielectric layer (5). The invention is further related to a method of production of said light modulation element and to the use of said light modulation element in various types of optical and electro-optical devices, such as electro-optical displays, liquid crystal displays (LCDs), non-linear optic (NLO) devices, and optical information storage devices.
    Type: Application
    Filed: December 30, 2015
    Publication date: January 18, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Ming-Chou WU, Kuan-Yu CHEN
  • Factor XIa inhibitors
    Patent number: 9868727
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: January 16, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Weiguo Liu, Scott D. Edmondson, Zhuyan Guo, Sung-Sau So, Anthony K. Ogawa, Rongze Kuang, Heping Wu, Amjad Ali, Ying-Duo Gao, Yu Jiang, Chunsing Li, Tingting Yu
  • Azabenzimidazole tetrahydrofuran derivatives
    Patent number: 9868733
    Abstract: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: January 16, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: James M. Apgar, Tesfaye Biftu, Ping Chen, Danqing Feng, Jacqueline D. Hicks, Ahmet Kekec, Kenneth J. Leavitt, Bing Li, Iyassu Sebhat, Xiaoxia Qian, Lan Wei, Robert R. Wilkening, Zhicai Wu, Ashok Arasappan
  • Colored polymer particles for electrophoretic displays
    Patent number: 9868803
    Abstract: This invention relates to colored polymer, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: January 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Louise Diane Farrand, Nils Greinert, Claire Topping, Jonathan Henry Wilson, Simon Biggs, Olivier Cayre, Simon Lawson, Alexandre Richez, Simone Stuart-Cole
  • Organic electroluminescent device
    Patent number: 9871213
    Abstract: The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent devices.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: January 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Esther Breuning, Arne Buesing, Amir Hossain Parham, Holger Heil, Horst Vestweber
  • Heterocycles as modulators of kinase activity
    Patent number: 9867826
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R. Huck, Andreas Goutopoulos
  • Liquid crystal displays and liquid crystalline media with homeotropic alignment
    Patent number: 9868904
    Abstract: The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy comprising self-aligning mesogens (SAMs) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the liquid-crystalline medium (LC medium) without conventional imide alignment layers. The LC media may be supplemented by a polymerizable or polymerized component, which serves for stabilization of the alignment, for adjustment of the tilt angle and/or as passivation layer.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: January 16, 2018
    Assignee: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Archetti Graziano, Andreas Taugerbeck
  • Diazine-fused amidines as BACE inhibitors, compositions, and their use
    Patent number: 9868738
    Abstract: In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I) or a tautomer thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1A, R1B, R2, RA, ring A, RA, m, L1, RL, ring C, RC, and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: January 16, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kun Liu, Shuwen He, Jared N. Cumming, Andrew W. Stamford
  • Electronic devices
    Patent number: 9871201
    Abstract: The application relates to an electronic device comprising anode, cathode, at least one emitting layer between anode and cathode, at least one p-doped layer A which comprises a monotriarylamine as host, and at least one layer B comprising a monotriarylamine. The invention furthermore relates to a p-doped mixture comprising a monotriarylamine of the formula (II), (III) or (IV) as host and an electron-acceptor compound as dopant and to the use of the mixture in an electronic device.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: January 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Christof Pflumm, Frank Voges, Jonas V. Kroeber, Philipp Stoessel, Joachim Kaiser
  • CMV neutralizing antigen binding proteins
    Patent number: 9868777
    Abstract: The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). Also encompassed by the invention are antigen binding proteins that have been humanized. The antigen binding proteins of the invention are useful as a therapeutic agent for treating and/or preventing CMV infections in a patient in need thereof.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: January 16, 2018
    Assignees: Merck Sharp & Dohme Corp., Board of Regents of the University of Texas System
    Inventors: Tong-Ming Fu, Dai Wang, Zhiqiang An
  • Hexahydro-1H-4,7-methanoisoindole-1,3-dione compounds
    Patent number: 9867821
    Abstract: The present invention is directed to therapeutic agents which are atypical antipsychotics and which are useful in the treatment of neurological and psychiatric disorders associated with dopamine D2 and serotonin 5-HT2A neurotransmission dysfunction.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: January 16, 2018
    Assignees: SUMITOMO DAINIPPON PHARMA CO., LTD., MERCK SHARP & DOHME CORP.
    Inventors: Mark T. Bilodeau, Kausik K. Nanda, B. Wesley Trotter
  • Compounds having a C—C triple bond and use thereof in liquid-crystal mixtures
    Patent number: 9868905
    Abstract: Compounds containing at least one C—C triple bond of the formula I R1-[A1-Z1]m-A2A3-[Z2-A4]n-[Z3-A5]o-R2??I, which have neutral dielectric anisotropy, to the use thereof for high-frequency components, to liquid-crystalline media comprising the compounds, and to high-frequency components, in particular antennae, especially for the giga- and terahertz region, comprising these media. The liquid-crystalline media serve, for example, for the phase shifting of microwaves for tuneable phased-array antennae.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: January 16, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Constanze Brocke, Christian Jasper, Detlef Pauluth, Atsutaka Manabe
  • POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS
    Publication number: 20180010046
    Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerisable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment type.
    Type: Application
    Filed: December 17, 2015
    Publication date: January 11, 2018
    Applicant: Merck Patent GmbH
    Inventors: Qiong TONG, Helga HAAS, Thorsten KODEK, Peer KIRSCH, Constanze BROCKE, Eveline BARON, Christoph MARTEN
  • DEVICE FOR THE REGULATION OF LIGHT TRANSMISSION
    Publication number: 20180011359
    Abstract: The present application discloses a switchable device, comprising a switching layer and a first conductive layer and a second conductive layer, where the switching layer is positioned between the first and the second conductive layer, and where at least one of the first and the second conductive layers comprises a plurality of isolating sections and a plurality of conductive sections, where the isolating sections and the conductive sections alternate over the area of the conductive layer, and where the switching state of the switchable device is controlled by touch motions.
    Type: Application
    Filed: December 22, 2015
    Publication date: January 11, 2018
    Applicant: Merck Patent GmbH
    Inventors: Ties DE JONG, Casper Laurens VAN OOSTEN
  • FORMULATIONS WITH A LOW PARTICLE CONTENT
    Publication number: 20180013067
    Abstract: The present invention relates to formulations comprising at least one organic semiconductor and at least one organic solvent, characterized in that the formulation contains less than 10,000 particles per liter formulation having an average size in the range from 0.1 to 20 ?m, to their use for the preparation of electronic devices, to methods for preparing electronic devices using the formulations of the present invention, and to electronic devices prepared from such methods and formulations.
    Type: Application
    Filed: January 21, 2016
    Publication date: January 11, 2018
    Applicants: Merck Patent GmbH, Seiko Epson Corporation
    Inventors: Edgar BOEHM, Anja GERHARD, Dietmar KUNKEL, Volker HILARIUS, Uchida MASAHIRO, Sonoyama TAKUYA, Takei SHUICHI, Imamura KOJI