Patents Assigned to Merck
  • Publication number: 20110118428
    Abstract: The present invention relates to novel compounds containing CF3O end groups, to the use thereof as surface-active substances, and to processes for the preparation of these compounds.
    Type: Application
    Filed: June 27, 2009
    Publication date: May 19, 2011
    Applicant: Merck Patent Gesellschaft Mit Beschrankterhaftung
    Inventors: Wolfgang Hierse, Eckhard Claus, Melanie Kleineidam, Peer Kirsch, Elvira Montenegro, Martin Seidel
  • Publication number: 20110117116
    Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.
    Type: Application
    Filed: January 15, 2010
    Publication date: May 19, 2011
    Applicant: MERCK PATENT GmbH
    Inventors: Wayne R. THOMAS, Kaw-Yan Chua, Bruce L. Rogers, Mei-chang Kuo
  • Patent number: 7943608
    Abstract: The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases in the development or course of which kinases are involved.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: May 17, 2011
    Assignee: Merck Patent GmbH
    Inventors: Melanie Schultz, Lars Thore Burgdorf, Dirk Finsinger, Andree Blaukat, Hartmut Greiner, Christina Esdar
  • Patent number: 7943637
    Abstract: Novel thienopyridine derivatives of the formula (I), in which R1, R2, R3 and Y have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: May 17, 2011
    Assignee: Merck Patent GmbH
    Inventors: Hans-Michael Eggenweiler, Michael Wolf
  • Patent number: 7943662
    Abstract: The invention relates to complexes of certain flavonoid derivatives, of the formula (I), where R1 and R2 are selected from H and OR11, where OR11 stands, independently of one another, for OH, straight-chain or branched C1- to C20-alkoxy groups, straight-chain or branched C3- to C20-alkenyloxy groups, straight-chain or branched C1- to C20-hydroxyalkoxy groups, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom in the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or C3- to C10-cycloalkoxy groups and/or C3- to C12-cycloalkenyloxy groups, where the rings may in each case also be bridged by —(CH2)n— groups, where n=1 to 3, and/or mono- and/or oligoglycosyl radicals, with the proviso that at least one radical from R1 and R2 stands for OR11, and R3 to R10 may be identical or different and stand, independently of one another, for radicals which are substantially inert with respect to the UV properties, to compositions which comprise such complexes, to corres
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: May 17, 2011
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Christophe Carola, Anne Toullec, Herwig Buchholz
  • Patent number: 7943061
    Abstract: The invention relates to chiral compounds, methods of their preparation, and to their use in optical, electrooptical, electronic, semiconducting or luminescent components or devices, and in decorative, security, cosmetic or diagnostic applications.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: May 17, 2011
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Louise Diane Farrand, Patricia Eileen Saxton
  • Patent number: 7943615
    Abstract: The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: May 17, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jason M. Cox, Scott D. Edmondson, Anthony Mastracchio
  • Patent number: 7943649
    Abstract: The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: May 17, 2011
    Assignee: Merck Frosst Canada Ltd.
    Inventors: Anh Chau, Bernard Cote, Yves Ducharme, Richard Frenette, Richard Friesen, Marc Gagnon, Andre Giroux, Evelyn Martins, Hongping Yu, Tom Wu
  • Patent number: 7943300
    Abstract: This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this respect, the invention offers a technology to improve the yield of functionally expressed recombinant proteins.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: May 17, 2011
    Assignee: Merck Patent GmbH
    Inventors: Uwe Horn, Ulrike Riesenberg, Wolfgang Strittmatter
  • Publication number: 20110108824
    Abstract: The present invention relates to electroluminescent polymers which comprise 2-vinylthiophenylbenzene derivatives as recurring units, to a process for the preparation thereof, to blends and formulations comprising these polymers, and to the use of these polymers in electronic devices, in particular in organic light-emitting diodes, so-called OLEDs.
    Type: Application
    Filed: August 4, 2009
    Publication date: May 12, 2011
    Applicant: MERCK PATENT GMBH
    Inventors: Susanne Heun, Aurélie Ludemann, Rémi Manouk Anemian, Niels Schulte
  • Publication number: 20110108818
    Abstract: The present invention relates to organic electroluminescent devices which comprise ketone or phosphine oxide derivatives as matrix material and at least two phosphorescent compounds.
    Type: Application
    Filed: November 18, 2009
    Publication date: May 12, 2011
    Applicant: Merck Patent GmbH
    Inventors: Joachim Kaiser, Arne Buesing, Anja Gerhard, Philipp Stoessel, Susanne Heun
  • Publication number: 20110112077
    Abstract: The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 12, 2011
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Scott D. KUDUK, Ronald K, CHANG
  • Publication number: 20110111976
    Abstract: One aspect of the invention generally relates to use of tissue enriched miRNAs as biomarker to estimate tissue damage in a fluid sample. In a second aspect, methods are provided for monitoring a subject who is exposed or might have been exposed to an agent that has a risk of causing tissue injury. In a third aspect, methods are provided for identifying an agent as having a risk of causing tissue injury to a vertebrate subject. In a fourth aspect, kits are provided for practicing the methods of above-listed aspects. The contents of this ABSTRACT are not intended to in anyway limit the scope of the inventions claimed herein.
    Type: Application
    Filed: April 24, 2009
    Publication date: May 12, 2011
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Thomas L. Fare, Philip W. Garrett-Engele, Warren E. Glaab, Jason M. Johnson, Omar F. Laterza, Lee Lim, Steve W. Ludmerer, David B. Olsen, Joseph F. Sina, Frank D. Sistare
  • Publication number: 20110108823
    Abstract: The present invention relates to aromatic amines and to electronic devices in which these amines are used, in particular, as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
    Type: Application
    Filed: September 10, 2009
    Publication date: May 12, 2011
    Applicant: MERCK PATENT GMBH
    Inventors: Philipp Stoessel, Holger Heil, Dominik Joosten, Christof Pflumm, Anja Gerhard
  • Publication number: 20110108769
    Abstract: The invention relates to the use of a multi-nuclear metal or transition metal complex in an organic electronic device, said complex having a small ?E spacing, particularly between 50 cm?1 and 2000 cm?1, between the lowest triplet state and the singlet state that is higher and is achieved by thermal backfilling from the triplet. The invention further relates to the use of the strong absorptions of such multinuclear metal complexes, particularly in OSCs.
    Type: Application
    Filed: June 23, 2009
    Publication date: May 12, 2011
    Applicant: Merck Patent GmbH
    Inventors: Hartmut Yersin, Uwe Monkowius
  • Publication number: 20110108822
    Abstract: The present invention relates to transition-metal complexes of the general formula I or II, in particular as emitter molecules in organic electronic devices, to a layer and to an electronic device which comprise the compounds according to the invention, and to a process for the preparation of the compounds according to the invention.
    Type: Application
    Filed: October 14, 2009
    Publication date: May 12, 2011
    Applicant: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Arne Buesing, Anja Gerhard, Joachim Kaiser, Rocco Fortte
  • Publication number: 20110112064
    Abstract: The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
    Type: Application
    Filed: January 18, 2011
    Publication date: May 12, 2011
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: James C. Barrow, Kelly-Ann S. Bieber, Rowena V. Cube, Mamio Christa Mattern, Thomas S. Reger, Youheng Shu, Zhi-Qiang Yang
  • Publication number: 20110108821
    Abstract: The present invention relates to white emitting organic electroluminescent devices having at least one blue fluorescent emitter layer.
    Type: Application
    Filed: May 22, 2009
    Publication date: May 12, 2011
    Applicant: Merck Patent GmbH
    Inventors: Joachim Kaiser, Horst Vestweber, Simone Leu, Arne Buesing, Holger Heil, Philipp Stoessel
  • Publication number: 20110112275
    Abstract: The present invention relates to condensed aromatic compounds with multiple ring bridging of the general formulae (1), (2), (3), (4) and (5). The invention furthermore relates to the use of the compounds according to the invention in an organic electronic device and to a process for the preparation of the compounds according to the invention. The invention furthermore relates to an electronic device which comprises the compounds according to the invention.
    Type: Application
    Filed: October 1, 2009
    Publication date: May 12, 2011
    Applicant: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Christof Pflumm, Holger Heil, Arne Buesing
  • Publication number: 20110112337
    Abstract: The invention relates to a method for the liquid-liquid extraction of alcohols from aqueous solutions using at least one ionic liquid containing a tricyanomethide anion as solvent.
    Type: Application
    Filed: May 28, 2009
    Publication date: May 12, 2011
    Applicant: MERCK PATENT GESELLSCHAFT
    Inventors: William-Robert Pitner, Emil Ferdinand Aust, Michael Schulte, Uschi Schmid-Grossmann