Patents Assigned to Merck
  • S,S'-bis(pyridylmethyl)-carbonodithioates
    Patent number: 3971797
    Abstract: S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
    Type: Grant
    Filed: May 16, 1974
    Date of Patent: July 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
  • Preparation of cyanopyridines
    Patent number: 3970659
    Abstract: Cyanopyridines are prepared by bringing a reactant stream comprising an alkyl substituted pyridine, ammonia, steam and oxygen into contact with a novel catalyst composition which results in high selectivity to the desired cyanopyridine.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: July 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Glenn R. Elion, Arthur E. Klink
  • Process for preparing indene acetic acids
    Patent number: 3970693
    Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl) benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid.This invention relates to new processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid, to intermediates thereof and processes for said intermediates.
    Type: Grant
    Filed: July 5, 1974
    Date of Patent: July 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
  • Preparation of cyanopyridines
    Patent number: 3970657
    Abstract: Cyanopyridines are prepared by bringing a reactant stream comprising an alkyl substituted pyridine, ammonia, steam and oxygen into contact with a novel catalyst composition which results in high selectivity to the desired cyanopyridine.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: July 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Glenn R. Elion, Arthur E. Klink
  • Inhibiting xanthine oxidase with 3-haloalkyl substituted benzothiadiazine-1,1-dioxides
    Patent number: 3969518
    Abstract: Method for decreasing the concentration of uric acid in the blood and urine of a mammal by the administration of a 3-haloalkyl-1,2,4-benzothiadiazine-1,1-dioxide product or 3,4-dihydro derivative thereof. The products employed in this method of treatment are prepared by conventional methods employing the appropriate orthanilamide and haloalkanoic acid halide or carboxaldehyde. The products effect the lowering of the uric acid level by virtue of their xanthine oxidase inhibiting properties.
    Type: Grant
    Filed: May 24, 1972
    Date of Patent: July 13, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Frederick C. Novello
  • 4-Nitro-5-cyanoimidazoles as coccidiostats
    Patent number: 3968228
    Abstract: 4-Nitro-5-cyanoimidazoles substituted with a 1-loweralkyl group and variously substituted at the 2-position are useful as antiparasitic agents particularly as coccidiostats. The 4-nitro-5-cyanoimidazole coccidiostats are included in compositions useful for administration to poultry as treatment for coccidiosis.
    Type: Grant
    Filed: February 10, 1975
    Date of Patent: July 6, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Dale R. Hoff, Peter Kulsa, Helmut H. Mrozik, Edward F. Rogers
  • 2-Aminomethyl-5-hydroxy-4H-pyran-4-one and derivatives thereof
    Patent number: 3968236
    Abstract: The 2-aminomethyl-5-hydroxy-4H-pyran-4-ones of the present invention are disclosed to have pharmaceutical utility as skeletal muscle relaxants. Also disclosed are processes for the preparation of such pyranones; pharmaceutical compositions comprising such compounds; and method of treatment comprising administering such compounds and compositions when a muscle relaxant effect is indicated.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: July 6, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Joshua Rokach, Clarence S. Rooney
  • 1-Alkyl-4-(10 and/or 11)-bromo-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-ylidene piperidine compounds
    Patent number: 3968115
    Abstract: The new 1-alkyl-4-(10-oxo or -hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine compounds are prepared from the corresponding 10-desoxy compounds having a double bond at the 10,11-position by a process involving bromination, dehydrobromination of the resulting dibromo compound, followed by enamine formation and hydrolysis to give the desired 10-oxo compound. The compounds prepared in this manner are active as antihistamines and as appetite stimulants.
    Type: Grant
    Filed: August 14, 1972
    Date of Patent: July 6, 1976
    Assignee: Merck & Co., Inc.
    Inventor: John D. Prugh
  • Phenoxypropionic acid derivatives
    Patent number: 3968143
    Abstract: Phenoxypropionic acid derivatives of the formula ##SPC1##Wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##SPC2##With a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.
    Type: Grant
    Filed: August 14, 1974
    Date of Patent: July 6, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Gunter Lauterbach, Werner Mehrhof, Herbert Nowak, Zdenek Simane
  • Pharmaceutical compositions and method of treatment employing 1,3-dioxo-2,2-disubstituted indanyloxy alkanoic acids
    Patent number: 3966966
    Abstract: [1,3-Dioxo-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids and their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a (2- or 2,2-di)substituted-6-hydroxy-(or mercapto)-1,3-indanedione with a haloalkanoic acid or ester thereof and if the ester is employed hydrolyzing the ester.
    Type: Grant
    Filed: July 31, 1974
    Date of Patent: June 29, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
  • Foam stable malt beverage
    Patent number: 3966976
    Abstract: This invention relates to a process for preparing malt beverages having good foam stability and improved lace and cling, and a method of preparing such beverages by adding 5 - 100 ppm of a polysaccharide colloid S-10.
    Type: Grant
    Filed: May 27, 1975
    Date of Patent: June 29, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Harry R. Schuppner, Jr., John H. Randel
  • Deuteration of functional group-containing hydrocarbons
    Patent number: 3966781
    Abstract: Deuterated functional group-containing hydrocarbons prepared by treating the non-labelled substrate in the liquid state with deuterium gas in the presence of a Group VII or VIII metal catalyst with heating between ambient to 300.degree. C. The labelled compounds are especially useful in reaction mechanism studies, as tracers in separation process studies, in the investigation of the physical properties of labelled compounds and in other specialized research work.
    Type: Grant
    Filed: December 10, 1973
    Date of Patent: June 29, 1976
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Joseph G. Atkinson, Michael O. Luke
  • Clarification of xanthan gum
    Patent number: 3966618
    Abstract: Fermentation broths and other aqueous suspensions containing a dissolved xanthan gum and suspended solids resulting from the fermentation producing the xanthan gum are clarified by treatment with a minor amount of a protease enzyme. The injectivity of aqueous solutions containing xanthan gum so clarified is improved, in oil well flooding operations, over solutions not so treated.
    Type: Grant
    Filed: October 10, 1974
    Date of Patent: June 29, 1976
    Assignee: Merck & Co., Inc.
    Inventor: George T. Colegrove
  • Prostaglandin E.sub.1 intermediate 3-carboxymethyl-4-methyl-2-1-carboxy-7-(loweralkoxy or aralkoxycarbonyl)-heptyl]-4-hydroxybutyric acid, .gamma.-lactone, and processes of their preparation
    Patent number: 3965120
    Abstract: Disclosed is a novel stereospecific synthesis of Prostaglandin E.sub.1.
    Type: Grant
    Filed: February 11, 1975
    Date of Patent: June 22, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Chan-Hwa Kuo, David Taub, Norman L. Wendler
  • Enzymatic determination of glucose
    Patent number: 3964974
    Abstract: Glucose is rapidly ad quantitatively determined with an analytical agent containing glucose dehydrogenase having an activity of at least 2 .mu./mg and NADH.sub.2 oxidase activity less than 0.1%, a pyridine coenzyme, a buffer and mutarotase to increase spontaneous mutarotation of alpha-glucose to beta-glucose. There may be optionally present inhibitors for reduced pyridine coenzyme oxidases and a thermal stabilizing amount of alkali metal chloride.
    Type: Grant
    Filed: September 10, 1973
    Date of Patent: June 22, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Dieter Banauch, Wolfgang Brummer, Wolfgang Ebeling, Roland Helger, Norbert Hennrich, Hermann Lang
  • Process for production of vaccines
    Patent number: 3965258
    Abstract: Process for producing a live virus vaccine for the immunization of chickens against Marek's disease utilizing a multiplate machine.
    Type: Grant
    Filed: April 16, 1975
    Date of Patent: June 22, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Kenneth L. Posch, Clarence L. Baugh, Raymond E. Spier
  • Pyridyl containing 1-benzenesulfonyl triazoles
    Patent number: 3963731
    Abstract: Compositions useful in the treatment of gout and hyperuricemia and containing a substituted 1,2,4-triazole as the active ingredient are provided, the triazoles being substituted at the 5 position with a pyridyl radical and at the 3 position with a phenyl or a pyridyl radical. Methods of preparing these substituted triazoles are described. Certain of the compounds are novel.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: June 15, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Frederick C. Novello, John J. Baldwin
  • Gas washer and liquid treatment system
    Patent number: 3963464
    Abstract: An injector type spray cooling system is described having a cooled water recovery sump in which water is directed through a strainer slanted with its upper edge upstream so that a self cleaning action is produced.
    Type: Grant
    Filed: March 6, 1974
    Date of Patent: June 15, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Edward N. Schinner
  • Synthetic antigens of luteinizing hormone releasing hormone
    Patent number: 3963691
    Abstract: Synthetic antigens related to luteinizing hormone-releasing hormone (hereinafter designated LH-RH) having the amino acid composition, pyroglutamyl-histidyl-tryptophanylseryl-tyrosyl-glycyl-leucyl-arginyl-prol yl-glycyl-poly-L-lysine (hereinafter designated pyroglu-his-trp-ser-tyr-glyleu-arg-pro-gly-poly-L-lys) and poly-L-lysyl-glutarylhistidyl-tryptophanyl-seryl-tyrosyl-glycyl-leucyl-arg inylprolyl-glycine amide (hereinafter designated poly-L-lysglutaryl-his-trp-ser-tyr-gly-leu-arg-pro-gly) are prepared by coupling the corresponding decapeptide with poly-L-lysine. The corresponding decapeptides are prepared by controlled stepwise procedures starting with individual amino acid components. These antigens have the property of inducing formation of antibodies to luteinizing hormone-releasing hormone (LH-RH) in animals.
    Type: Grant
    Filed: October 7, 1974
    Date of Patent: June 15, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Carl H. Hoffman, Harvey Schwam, Stephen F. Brady, Martin Hichens, Ruth F. Nutt
  • Cephalosporin compounds
    Patent number: 3962224
    Abstract: Novel 7-azido-3-cephem compounds are prepared via .alpha.-amino-phosphonoacetate esters. The cephem compounds are intermediates for the preparation of novel and known useful antibiotic cephalosporins.
    Type: Grant
    Filed: March 5, 1973
    Date of Patent: June 8, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe