Patents Assigned to Merck
  • Substituted N?-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
    Patent number: 11034661
    Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: June 15, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Liangqin Guo, Yongxin Han, Kun Liu, Shuwen He, Joseph Kozlowski, Ravi Nargund, Wensheng Yu, Hongjun Zhang, Qinglin Pu, Derun Li, Abdelghani Achab, Guoqing Li
  • Water purification and dispensing system and method
    Patent number: 11035484
    Abstract: The invention provides a water purification and dispensing system, preferably for producing ultrapure water and offering the purified water at one or more dispensing sites in a desired volume.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: June 15, 2021
    Assignee: Merck Patent GmbH
    Inventors: Pascal Roitel, Christophe Paragot, Laurent Moreau
  • Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Patent number: 11033547
    Abstract: The invention relates to carboxamide-pyrimidine derivatives of the general formula I, or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: June 15, 2021
    Assignee: Merck Patent GmbH
    Inventors: Catherine Jorand-LeBrun, Roch Boivin, Igor Mochalkin, Theresa Johnson, Nina Linde, Doreen Musch, Deepak Kumar
  • METAL COMPLEXES
    Publication number: 20210175441
    Abstract: The present invention relates to iridium complexes suitable for use in organic electroluminescent devices, especially as emitters.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 10, 2021
    Applicant: Merck Patent GmbH
    Inventors: Philipp Stoessel, Armin Auch
  • LIQUID-CRYSTALLINE MEDIUM FOR USE IN A SWITCHING ELEMENT
    Publication number: 20210171830
    Abstract: The present invention relates to liquid-crystalline media comprising one or more mesogenic compounds, one or more chiral compounds, and one or more polymerisable mesogenic compounds, wherein the media exhibit a pitch of 0.55 ?m or more and a clearing point of 80° C. or more and wherein the one or more polymerisable mesogenic compounds are contained in an amount, based on the overall contents of the media, of 5% by weight or less. The present invention further relates to modulation materials obtainable from the media and to switching layers and window elements containing the materials.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 10, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Paul VERBUNT, Ties DE JONG, Michael JUNGE, Mila FISCHER
  • Cladribine regimen for treating progressive forms of Multiple Sclerosis
    Publication number: 20210169912
    Abstract: Specific oral dosings, specific oral dosage forms, and/or specific oral dose regimens including Cladribine can be effective for the treatment of progressive forms of Multiple Sclerosis, especially Primary Progressive Multiple Sclerosis and/or Secondary Progressive Multiple Sclerosis. Methods of treatment can be based on specific oral dosings, specific oral dosage forms, and/or specific oral dose regimens including Cladribine.
    Type: Application
    Filed: October 23, 2020
    Publication date: June 10, 2021
    Applicant: Merck Patent GmnH
    Inventors: Fernando Dangond, Matthias Dotzauer
  • Piperidinyl-propanone derivatives
    Patent number: 11026936
    Abstract: Compounds of the formula I in which X, Q, R1 and R2 have the meanings indicated in Claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: June 8, 2021
    Assignee: Merck Patent GmbH
    Inventor: Hans-Peter Buchstaller
  • Metal complexes
    Patent number: 11031562
    Abstract: The present invention relates to metal complexes and to electronic devices, especially organic electroluminescent devices, comprising these metal complexes.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 8, 2021
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Nils Koenen, Christian Ehrenreich
  • Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Patent number: 11028092
    Abstract: The present invention is directed to pyrazolopyrimidine compounds of the general structural formula I: which may be useful as therapeutic agents for the treatment of disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating cardiovascular and cerebrovascular diseases, such as hypertension, chronic kidney disease and heart failure, and neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: June 8, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Ashok Arasappan, Jason M. Cox, John S. Debenham, Zahid Hussain, Derun Li, Dongfang Meng, Subharekha Raghavan
  • Chemically amplified positive photoresist composition and pattern forming method using same
    Patent number: 11029599
    Abstract: The present invention relates to a photosensitive resin composition suitable for forming a thick film, which comprises (A) an alkali-soluble resin, (B) at least one plasticizer selected from a group consisting of an alkali-soluble vinyl resin and an acid-dissociable group containing vinyl resin, (C) an acid generator, and (D) an organic solvent.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 8, 2021
    Assignee: Merck Patent GmbH
    Inventors: Tetsumasa Takaichi, Shunji Kawato, Masato Suzuki, Kazumichi Akashi, Tomohide Katayama
  • Black matrix composition, black matrix, and black matrix production method
    Patent number: 11028270
    Abstract: [Problem] To provide a composition for a black matrix which is a material suitable for manufacturing a black matrix, which is suitable for a high luminance display device structure and has high heat resistance and high light-shielding properties. [Means for Solution] The present invention uses a composition for a black matrix comprising: (I) a black colorant containing carbon black having a volume average particle diameter of 1 to 300 nm; (II) a siloxane polymer to be obtained by hydrolyzing and condensing a silane compound represented by a prescribed formula in the presence of an acidic or basic catalyst; (III) surface modified silica fine particles; (IV) a thermal base generator; and (V) a solvent.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: June 8, 2021
    Assignee: Merck Patent GmbH
    Inventors: Hirohiko Nishiki, Tohru Okabe, Izumi Ishida, Shogo Murashige, Atsuko Noya, Toshiaki Nonaka, Naofumi Yoshida
  • Aromatic amino siloxane functionalized materials for use in capping porous dielectrics
    Patent number: 11031237
    Abstract: The present invention relates to new aromatic-amino functional siloxanes, which are compounds comprising one or two tail groups X2, and a linking group L of structure (2) linking each said tail group to said head group, wherein the head group X has structure (1), containing an optional organic moiety Y, wherein the attachment point of said tail group X2 through said linking group L to the head group X1, may be, at positions a, b, c, d, or e. Another aspect of this invention are compositions containing these novel aromatic amino functional siloxane. A further aspect of this invention are compositions comprised of the above novel aromatic-amino functional siloxanes, and also the composition resulting from the aging of these compositions at room temperature for about 1 day to about 4 weeks.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: June 8, 2021
    Assignee: Merck Patent GMbH
    Inventors: Sachin Bobade, Orest Polishchuk, Munirathna Padmanaban, Durairaj Baskaran
  • Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
    Patent number: 11026958
    Abstract: The present disclosure relates to compounds of formula (I) that are useful as modulators of ?7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: June 8, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Brendan M. Crowley, Ian M. Bell, Andrew John Harvey, Brian T. Campbell, Thomas J. Greshock, Vanessa L. Rada
  • Multi-level convolutional LSTM model for the segmentation of MR images
    Patent number: 11030750
    Abstract: Approaches for the automatic segmentation of magnetic resonance (MR) images. Machine learning models segment images to identify image features in consecutive frames at different levels of resolution. A neural network block is applied to groups of MR images to produce primary feature maps at two or more levels of resolution. The images in a given group of MR images may correspond to a cycle and have a temporal order. A second RNN block is applied to the primary feature maps to produce two or more output tensors at corresponding levels of resolution. A segmentation block is applied to the two or more output tensors to produce a probability map for the MR images. The first neural network block may be a convolutional neural network (CNN) block. The second neural network block may be a convolutional long short-term (LSTM) block.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: June 8, 2021
    Assignees: Merck Sharp & Dohme Corp., MSD International GmbH
    Inventors: Antong Chen, Dongqing Zhang, Ilknur Icke, Belma Dogdas, Sarayu Parimal
  • 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
    Patent number: 11028054
    Abstract: The present invention provides 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitor compounds of formula (I), which may be therapeutically useful as DHODH inhibitors, in which R1 to R3 and ‘m’ have the meanings given in the specification, and pharmaceutically acceptable salts or stereoisomer thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting DHODH. The present invention also provides methods for synthesizing 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives of formula (I). The present invention also provides pharmaceutical formulations comprising at least one of the DHODH inhibitor compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: June 8, 2021
    Assignee: Merck Patent GmbH
    Inventors: Siva Sanjeeva Rao Thunuguntla, Subramanya Hosahalli, Sunil Kumar Panigrahi, Matthias Schwarz, Michael Arit
  • DISPLAY DEVICE, PRODUCTION AND USE THEREOF
    Publication number: 20210163763
    Abstract: The present invention relates to a display device, in particular a backlit display device having a visible side and a back side, which appears opaque in colour and texture on viewing of the visible side without backlighting, but, with the backlighting switched on, is sufficiently transparent that the transmission of information by the light source from the back side is possible, and to the production of a display device of this type and to the use thereof.
    Type: Application
    Filed: July 17, 2019
    Publication date: June 3, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Sabine EBERLE, Udo GUMSHEIMER
  • USE OF SPECIFIC BENZYLIDENE MALONATES FOR PROTECTING THE SKIN FROM CHEMICALLY INDUCED STRESS
    Publication number: 20210161783
    Abstract: The invention relates to the use of specific benzylidenemalonates, in particular in a cosmetic preparation, for protecting the skin against chemically induced stress, in particular against chemically induced stress caused by heavy metals and/or particulate matter, or for the prevention and/or prophylaxis of epidermal morphological change.
    Type: Application
    Filed: April 9, 2019
    Publication date: June 3, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Marina LEFORT, Lilia HEIDER, Valerie BICARD BENHAMOU, Silke HORNUNG
  • NOVEL SUBSTITUTED TETRAHYDROQUINOLINE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS
    Publication number: 20210161896
    Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Application
    Filed: August 12, 2019
    Publication date: June 3, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dane Clausen, Xavier Fradera, Yongxin Han, Alexander Pasternak, Li Xiao, Hongjun Zhang
  • LIQUID-CRYSTALLINE MEDIUM FOR USE IN A SWITCHING ELEMENT
    Publication number: 20210163820
    Abstract: The present invention relates to liquid-crystalline media comprising one or more mesogenic compounds of formula I as set forth hereinafter, wherein the one or more compounds of formula I are contained in the medium in an amount, based on the overall contents of the medium, of at least 15% by weight. The present invention further relates to a switching layer, a switching element and a window element containing the liquid-crystalline medium.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 3, 2021
    Applicant: Merck Patent GmbH
    Inventors: Michael JUNGE, Andreas BEYER, Mila FISCHER, Ewa PTAK
  • Packaging
    Patent number: D922197
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: June 15, 2021
    Assignee: Merck KGaA
    Inventors: Mark Hinkle, Jeffrey Whitford