Patents Assigned to Merck
  • Double Layer Liquid Crystal Device and Process of Manufacture
    Publication number: 20210096431
    Abstract: A double layer liquid crystal device comprises a first and a second layer with orthogonal or crossed alignment of the liquid crystal phase of the two layers, in which the first and second layer have first and second alignment aids comprised of a polymerized or polymerizable molecular compound. The layers are aligned by UV photoalignment and vertical self-alignment by the aid of suitable additives.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Applicant: Merck Patent GmbH
    Inventors: Joseph SARGENT, Sarabjot KAUR, Simon SIEMIANOWSKI, Izumi SAITO
  • ANTIDIABETIC BICYCLIC COMPOUNDS
    Publication number: 20210094938
    Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia Formula (I).
    Type: Application
    Filed: November 12, 2018
    Publication date: April 1, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Steven L. Colletti, Duane DeMong, Kevin D. Dykstra, Zhiyong Hu, Michael Miller
  • DRUG DELIVERY SYSTEM FOR THE DELIVERY OF ANTIVIRAL AGENTS
    Publication number: 20210093555
    Abstract: This invention relates to novel implant drug delivery systems for long-acting delivery of antiviral drugs. These compositions are useful for the treatment or prevention of human immunodeficiency virus (HIV) infection.
    Type: Application
    Filed: April 5, 2018
    Publication date: April 1, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Stephanie Elizabeth Barrett, Marian E. Gindy, Li Li, Ryan S. Teller, Seth P. Forster
  • RECOMBINANT EXPRESSION OF CHLAMYDIA MOMP ANTIGEN
    Publication number: 20210093703
    Abstract: The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.
    Type: Application
    Filed: June 8, 2020
    Publication date: April 1, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal, Ping Qiu
  • N-aryl and N-heteroaryl piperidine derivatives as liver X receptor beta agonists, compositions, and their use
    Patent number: 10961215
    Abstract: In its many embodiments, the present invention provides certain substituted N-aryl and N-heteroaryl piperidine compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, L, R4, L1, Q, R5 and R6 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, may be useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: March 30, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michael T. Rudd, Zhaoyang Meng, Jenny Wai, David Jonathan Bennett, Edward J. Brnardic, Nigel J. Liverton, Shawn J. Stachel, Yongxin Han, Paul Tempest, Jiuxiang Zhu, Xuewang Xu
  • Liquid-crystalline medium
    Patent number: 10961457
    Abstract: The present invention relates to liquid-crystalline media comprising a) one or more compounds of the formula ST-1, as defined herein, and b) one or more compounds of the formula ST-2, as defined herein, and c) one or more compounds of the formula RV, as defined herein, and d) one or more compounds selected from formula IA and IB, as defined herein, and to liquid-crystal displays containing these media, especially to displays addressed by an active matrix and in particular to displays of the in-plane switching (IPS) or fringe-field switching (FFS) type.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: March 30, 2021
    Assignee: Merck Patent GmbH
    Inventors: Chang-Jun Yun, Chang-Suk Choi, Yeon-Jeong Han, Heui-Seok Jin, Yong-Kuk Yun
  • F-labelled folates as PET radiotracers
    Patent number: 10961246
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 30, 2021
    Assignee: MERCK & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Simon Mensah Ametamey, Tobias Ludwig Ross, Viola Groehn
  • Materials for organic electroluminescent devices
    Patent number: 10961230
    Abstract: The present invention describes amines with dibenzofuran or dibenzothiophene groups in combination with carbazole, especially for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these compounds.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: March 30, 2021
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Thomas Eberle, Anja Jatsch, Tobias Grossmann, Jonas Valentin Kroeber, Elvira Montenegro, Dominik Joosten, Caroline Wern
  • Carbazole derivatives
    Patent number: 10964894
    Abstract: The present invention relates to carbazole derivatives, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: March 30, 2021
    Assignee: Merck Patent GmbH
    Inventors: Amir Parham, Aurélie Ludemann, Dominik Joosten, Tobias Grossmann, Jonas Kroeber
  • PIGMENTS
    Publication number: 20210087403
    Abstract: Pigments based on particles which are coated with at least one layer which consists of a mixture of amorphous carbon (a-C) and nanocrystalline graphite (nc-graphite) and use of these pigments in, for example, paints, plastics, industrial coatings, automotive coatings, printing inks and cosmetic formulations.
    Type: Application
    Filed: September 1, 2020
    Publication date: March 25, 2021
    Applicant: MERCK PATENT GMBH
    Inventors: Adeliene SCHMITT, Udo GUMSHEIMER
  • Pharmaceutical formulation
    Publication number: 20210085611
    Abstract: A pharmaceutical formulation has (S)-[2-chloro-4-fluoro-5-(7-tnorpholin-4-yl-quinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)methanol or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 28, 2018
    Publication date: March 25, 2021
    Applicant: Merck Patent GmbH
    Inventors: Simon GEISSLER, Martina Jeschke, Patrizia Boniforte, Markus Weigandt
  • Fluorine containing polymers
    Patent number: 10954323
    Abstract: The present invention relates to novel fluorine containing polymers, compositions comprising the polymers, the use of the polymers in coatings, especially in water and dirt repellent coatings, and products coated with polymer containing coatings.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 23, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Haibo Fang, Reiner Friedrich
  • 4?-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof
    Patent number: 10953029
    Abstract: The present invention is directed to 4?-substituted nucleoside derivatives of Formula (I) and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4?-substituted nucleoside derivatives of Formula (I) and derivatives thereof.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: March 23, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Vinay M. Girijavallabhan
  • Ink composition of an organic functional material
    Patent number: 10954403
    Abstract: The present invention relates to an ink composition comprising an organic functional material having a molecular weight of at most 5,000 g/mol and a first organic solvent selected from the group consisting of terpene, terpenoid, and combination of any of these, as well as to the use of the ink composition, an electronic device prepared by using the ink composition and method for preparing/fabricating thereof.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: March 23, 2021
    Assignee: Merck Patent GmbH
    Inventors: Li Wei Tan, Pawel Miskiewicz, Philip Edward May, Daniel Walker
  • Materials for electronic devices
    Patent number: 10957860
    Abstract: The application relates to a compound of a formula (I) which is suitable for use as functional material in electronic devices.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 23, 2021
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Elvira Montenegro, Frank Voges, Jonas Valentin Kroeber, Philipp Stoessel
  • Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Patent number: 10954240
    Abstract: The present invention is directed to substituted certain reversed indazole compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R9, and A are as defined herein, which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: March 23, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Xing Dai, Kallol Basu, Duane DeMong, Sarah W. Li, Michael Miller, Jack D. Scott, Andrew W. Stamford
  • Insulin receptor partial agonists and GLP-1 analogues
    Patent number: 10953076
    Abstract: The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: March 23, 2021
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Yingjun Mu, Songnian Lin
  • Materials for organic light-emitting devices
    Patent number: 10957864
    Abstract: The invention relates to compounds which are suitable for use in electronic devices, and electronic devices, in particular organic electroluminescent devices, containing said compounds.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: March 23, 2021
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Anja Jatsch, Tobias Grossmann, Thomas Eberle, Jonas Valentin Kroeber, Rouven Linge
  • Heterocyclic compounds for use in electronic devices
    Patent number: 10957859
    Abstract: The present invention relates to heterocyclic compounds and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: March 23, 2021
    Assignee: Merck Patent GmbH
    Inventors: Anja Jatsch, Amir Hossain Parham, Thomas Eberle, Tobias Grossmann, Jonas Valentin Kroeber
  • Water purifier
    Patent number: D914835
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: March 30, 2021
    Assignee: Merck Patent GmbH
    Inventors: Laurent Moreau, Thierry Cassou