Patents Assigned to Merial Limited
  • Publication number: 20150283228
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
    Type: Application
    Filed: February 6, 2015
    Publication date: October 8, 2015
    Applicants: MERIAL LIMITED, UNIVERSITE PARIS-SUD, INSTITUT GUSTAVE ROUSSY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Herve Poulet, Thierry Heidmann
  • Publication number: 20150196487
    Abstract: The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.
    Type: Application
    Filed: February 26, 2015
    Publication date: July 16, 2015
    Applicant: MERIAL LIMITED
    Inventors: Noel Joseph Francois Detraz, Guillaume Rigaut
  • Publication number: 20150190502
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Application
    Filed: November 17, 2014
    Publication date: July 9, 2015
    Applicant: MERIAL LIMITED
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma
  • Publication number: 20150164864
    Abstract: This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II): or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 20, 2015
    Publication date: June 18, 2015
    Applicant: MERIAL LIMITED
    Inventors: Mark David Soll, Diane Larsen, Susan Mancini Cady, Peter Cheifetz, Izabela Galeska
  • Publication number: 20150166485
    Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
    Type: Application
    Filed: February 20, 2015
    Publication date: June 18, 2015
    Applicant: MERIAL LIMITED
    Inventor: Charles Q. Meng
  • Publication number: 20150157704
    Abstract: The present invention encompasses recombinant Newcastle Disease Virus-Herpesvirus vaccines or compositions. The invention encompasses recombinant NDV vectors encoding and expressing herpesvirus pathogen, antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals against disease.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 11, 2015
    Applicant: MERIAL LIMITED
    Inventors: Michel Bublot, Frederic Reynard, Herve Poulet, Frederic Raymond David
  • Publication number: 20150136030
    Abstract: The present disclosure relates to a device for delivering substances to specific embryonic structures, including heart and blood vessels, within a developing avian egg. The disclosure also relates to methods of using the device to produce enhanced avian embryos. Methods include administering to chicken embryos various substances, including vaccines, nutrients, and stem cells. Chickens resulting from enhanced avian embryos have advantages, including greater growth potential and resistance to pathogen infection/infestation.
    Type: Application
    Filed: October 17, 2014
    Publication date: May 21, 2015
    Applicants: MAT Malta Advanced Technologies Limited, Merial Limited
    Inventors: Sven Meissner, Stefan Geissler, Toni Frohnert, Doreen Goehler, Bjoern Fischer
  • Publication number: 20150128873
    Abstract: The application discloses a multi-chamber, multi-formulation fluid delivery system, comprising a multi-chamber applicator in fluid communication with multi-chamber packaging. Applicators according to the instant disclosure have reduced squeeze-strength requirements, and are useful for dispensing fluids, including medicaments, to animals, including livestock animals. The multi-chamber packaging provides separate storage for formulations containing incompatible active ingredients, and is suitable for use with the multi-chamber applicator. The application also discloses methods for using the system to simultaneously deliver multiple active ingredients, at least some of which are not suitable for co-formulation, thus reducing the time, economic burden and animal stress involved with applying multiple, separate formulations to animals.
    Type: Application
    Filed: September 17, 2014
    Publication date: May 14, 2015
    Applicant: MERIAL LIMITED
    Inventors: Todd Luepke Prescott, Rodney Gordon Walker, Gareth Nigel Lauchlan, David Andrew Trow
  • Publication number: 20150125487
    Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.
    Type: Application
    Filed: October 30, 2014
    Publication date: May 7, 2015
    Applicant: MERIAL LIMITED
    Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
  • Publication number: 20150126523
    Abstract: The present invention relates to novel and inventive isoxazoline of formula (I) and salts thereof: wherein variables D1, D2, D3, D4, D5, R1, B1, B2, B3, R2, R3, R4, R5, R6, Y, Z, L, a and b are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
    Type: Application
    Filed: October 30, 2014
    Publication date: May 7, 2015
    Applicant: MERIAL LIMITED
    Inventor: Charles Q. Meng
  • Publication number: 20150098968
    Abstract: The present invention is a Haemophilus parasuis vaccine against serovar type 4 capable of triggering a protective immune response when administered to pigs as a killed vaccine. The present invention is also a method for vaccinating swine against Haemophilus parasuis infection, serovar type 4, by a) clonally propagating one or more cells which are capable of triggering an immune response against Haemophilus parasuis infection, serovar type 4, that protects the pig against Haemophilus parasuis infection, and b) combining an immunologically effective amount of the cells with a veterinarily acceptable carrier in a form suitable for administration as a vaccine to the pig, and c) administering as a killed vaccine. The cell culture is from a pathogenic parent strain.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 9, 2015
    Applicant: MERIAL LIMITED
    Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
  • Publication number: 20150073153
    Abstract: Provided are improved processes for the preparation of 1-aryl pyrazole compounds of formula (I) and (IB): which are substituted at the 5-position of the pyrazole ring with a carbon-linked functional group. The process described are efficient and scalable and do not utilize hazardous sulfenyl halide reagents.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Applicant: Merial Limited
    Inventors: Charles Q. Meng, Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Xinxi Zhan, Jean Robert Labrosse, Michel Mulhauser
  • Patent number: 8945070
    Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: February 3, 2015
    Assignee: Merial Limited
    Inventors: Robert William Lachlan Holmes, Rodney Gordon Walker, Todd Donald Ebbett, Colin Anthony Standing, Peter Robert Williams, Giovanni Ciampa, Michael Rossignuolo, Robert John Smith
  • Patent number: 8946270
    Abstract: The subject matter disclosed herein is directed to amido-pyridyl ether compounds of formula I: wherein, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, Ra, a, b and d are as described herein, compositions comprising the compounds of formula I, methods for their preparation and methods for their uses against parasites.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: February 3, 2015
    Assignee: Merial Limited
    Inventors: Charles Q. Meng, Clare Louise Murray, Itta Bluhn-Chertudi, Mustapha Soukri, Mary George Johnson
  • Publication number: 20150030623
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 29, 2015
    Applicants: Merial Limited, Centre National De la Recherche Scientifique, Institut Gustave Roussy, Universite Paris-Sud
    Inventors: Herve Poulet, Thierry Heidmann
  • Patent number: 8937185
    Abstract: Provided are improved processes for the preparation of 1-aryl pyrazole compounds of formula (I) and (IB): which are substituted at the 5-position of the pyrazole ring with a carbon-linked functional group. The process described are efficient and scalable and do not utilize hazardous sulfenyl halide reagents.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: January 20, 2015
    Assignee: Merial Limited
    Inventors: Charles Q Meng, Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Xinxi Zhan, Jean Robert Labrosse, Michel Mulhauser
  • Publication number: 20150011601
    Abstract: This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds in combination with substituted imidazole compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to an animal in need thereof.
    Type: Application
    Filed: September 23, 2014
    Publication date: January 8, 2015
    Applicant: MERIAL LIMITED
    Inventor: Charles Q. Meng
  • Publication number: 20150011943
    Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.
    Type: Application
    Filed: September 25, 2014
    Publication date: January 8, 2015
    Applicant: MERIAL LIMITED
    Inventors: Robert William Lachlan Holmes, Rodney Gordon Walker, Todd Donald Ebbett, Colin Anthony Standing, Peter Robert Williams, Giovanni Ciampa, Michael Rossignuolo, Robert John Smith
  • Patent number: 8921408
    Abstract: This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds alone or in combination with formamidine compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to the animal in need thereof.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: December 30, 2014
    Assignee: Merial Limited
    Inventors: Mark David Soll, Luiz Gustavo Cramer, Patrice Wurtz, James Pate, Natalya Shub, Loic Patrick Le Hir de Fallois, Philip Reid Timmons
  • Patent number: 8916371
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 23, 2014
    Assignee: Merial Limited
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma