Patents Assigned to Merial Limited
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Patent number: 8124642Abstract: The invention relates to 5-(substituted dithio- or dioxy-alkylamino)pyrazole derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).Type: GrantFiled: March 23, 2009Date of Patent: February 28, 2012Assignee: Merial LimitedInventors: David Chou, Werner Knauf, Michael Maier, Friederike Lochhaas, Stefan Schnatterer, Karl Seeger
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Patent number: 8105776Abstract: The presence of horns within commercial cattle populations increases the chances of injuries. The Polled (hornless) condition in cattle has existed since domestication, and it has been selected by breeders because of its economic importance and ease of management. A dominant mutation is believed to cause the polled phenotype. The present invention relates to the identification of breed-specific single nucleotide polymorphisms (SNPs) and their haplotypes, in the bovine genome, in or near gene(s) encoding polypeptides associated with the Polled phenotyped in beef production.Type: GrantFiled: December 18, 2008Date of Patent: January 31, 2012Assignees: Merial Limited, The Texas A&M University SystemInventors: Clare A. Gill, Stewart Bauck, Brent Woodward, Nathan Voss
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Patent number: 8097732Abstract: Disclosed are compounds of formula (I) or pesticidally acceptable salts thereof, wherein, for example, W is ?N—, ?CH—, ?CR7— or ?C(NR8R9)—, R7 is halogen, R8 and R9 are independently of one another hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, aralkyl or heterocyclylalkyl, R1 is cyano, halogen, haloalkyl or CS NH2, R2 is alkyl or cycloalkyl, R3 is hydrogen, alkyl or cycloalkyl, R4 is hydrogen, alkyl or cycloalkyl, R5 is haloalkyl, haloalkoxy, halogen or —SF5, R6 is hydrogen, halogen, haloalkyl, nitro or NR16R17, R16 and R17 are independently of one another hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, aralkyl or heterocyclylalkyl, X is —S—, —SO—, or —SO2—, Y is —O—, —S—, —SO—, or SO2—, Z is hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, aralkyl, heterocyclylalkyl or NR18R19, and R18 and R19 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, aralkyl, heterocyclylalkyl.Type: GrantFiled: June 18, 2007Date of Patent: January 17, 2012Assignee: Merial LimitedInventors: David T. Chou, Michael Maier, Friederike Petry, Werner Knauf
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Patent number: 8097266Abstract: This invention relates to pharmaceutical and veterinary formulations providing enhanced solvency and stability for pharmaceutical and veterinary agents for administration to animals, especially ruminants. In addition, the invention relates to pour-on formulations for combating parasites in animals, such as cattle and sheep. In some embodiments, this invention provides glycol-ether-based pour-on formulations comprising a composition comprising a flukicide, such as, for example, clorsulon (4-amino-6-trichloroethenyl-1,3-benzene disulfonamide) and/or a macrolide anthelmintic or antiparasitic agent. In other embodiments, the invention provides pour-on formulations comprising at least one active agent, a glycol ether, and a stability enhancer. This invention also provides for methods for eradicating, controlling, and/or preventing parasite infestation in animals, such as cattle and sheep.Type: GrantFiled: November 26, 2008Date of Patent: January 17, 2012Assignee: Merial LimitedInventors: Ronald Peter Gogolewski, Douglas Cleverly, Paul Thwaites, Mark David Soll
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Patent number: 8097599Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.Type: GrantFiled: June 4, 2010Date of Patent: January 17, 2012Assignee: Merial LimitedInventor: Laurent Bernard Fischer
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Publication number: 20120009218Abstract: Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.Type: ApplicationFiled: April 20, 2011Publication date: January 12, 2012Applicant: Merial LimitedInventors: Helen Rachel Crooke, Jacqueline Elizabeth Shea, Robert Graham Feldman, Sylvain Gabriel Goutebroze, Francois-Xavier Le Gros
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Patent number: 8088801Abstract: The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives of formula (I): wherein R3, R4, R5, R6, R7, P, Q, V, W, X, Y, Z and a are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.Type: GrantFiled: May 12, 2008Date of Patent: January 3, 2012Assignees: Merial Limited, Aventis AgizicultureInventors: Mark David Soll, Loïc Patrick Le Hir de Fallois, Scot Kevin Huber, Hyoung Ik Lee, Douglas Edward Wilkinson, Robert Toms Jacobs
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Patent number: 8067382Abstract: The invention relates to a novel formulation having the advantage of including triclabendazole in solution. In addition a further anthelmintic may be included. The formulation is made by mixing the abamectin and benzyl alcohol and mixing this with triclabendazole and butyl dioxitol. The mix is then heated to dissolve the active, and allowed to cool at which stage the solution is diluted to volume with PEG 4000. The present invention overcomes the solubility difficulties of triclabendazole and presents the triclabendazole in a solution.Type: GrantFiled: December 7, 2009Date of Patent: November 29, 2011Assignee: Merial LimitedInventor: Colin Manson Harvey
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Patent number: 8062645Abstract: The present invention relates to the field of vaccination against Salmonella in animals, particularly avian animals. The present invention also encompasses kits and uses of Salmonella immunogenic compositions or vaccines. The present invention further relates to methods and compositions comprising at least one primo-administration of an attenuated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle and at least one attenuated Salmonella, administered to an avian animal before at least one boost-administration of an inactivated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle, and at least one inactivated Salmonella.Type: GrantFiled: December 10, 2007Date of Patent: November 22, 2011Assignee: Merial LimitedInventors: François-Xavier Le Gros, Stephane Lemiere
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Publication number: 20110212129Abstract: The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs, d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus, and e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus.Type: ApplicationFiled: December 7, 2010Publication date: September 1, 2011Applicants: SANOFI PASTEUR S.A., MERIAL LIMITEDInventors: Catherine Gerdil, Catherine Moste, Isabelle Legastelois, Michel Marie Joseph Bublot, François-Xavier Le Gros
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Patent number: 8008268Abstract: The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against vesicular stomatitis virus (VSV) in an animal susceptible to VSV. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain at least one heterologous nucleic acid molecule(s), expresses in vivo in the animal VSV antigen(s), immunogen(s) or epitope(s) thereof, e.g., VSV G protein and/or VSV N protein and/or VSV M protein. The heterologous nucleic acid molecule(s) may be adjusted to the vector/mammalian cell system by codon optimization. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.Type: GrantFiled: August 16, 2006Date of Patent: August 30, 2011Assignee: Merial LimitedInventors: Jiansheng Yao, Jules Maarten Minke, Jean Christophe Audonnet
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Patent number: 7998733Abstract: The present invention relates to chimeric vectors. More specifically, the invention relates to recombinant poxvirus vectors and viruses that are capable of expressing an alphaviral RNA replicon expressing a heterologous sequence of interest.Type: GrantFiled: October 5, 2004Date of Patent: August 16, 2011Assignee: Merial LimitedInventors: Jiansheng Yao, Sheena May Loosmore, Jean-Christophe Francis Audonnet
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Patent number: 7964621Abstract: The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): wherein, R3, R4, R5, R6, R7, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.Type: GrantFiled: October 20, 2009Date of Patent: June 21, 2011Assignee: Merial LimitedInventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Philip Reid Timmons
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Patent number: 7943125Abstract: Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.Type: GrantFiled: October 7, 2008Date of Patent: May 17, 2011Assignee: Merial LimitedInventors: Helen Rachel Crooke, Jacqueline Elizabeth Shea, Robert Graham Feldman, Sylvain Gabriel Goutebroze, Francois-Xavier Le Gros
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Patent number: 7919522Abstract: Provided is a novel ivermectin derivative and compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (A) a pharmaceutically effective amount of a 1-N-phenylpyrazole compound; (B) a pharmaceutically effective amount of an ivermectin derivative of formula (II) wherein: R14 represents —(CH2)s—O—Z wherein, s is 1 or 2; Y represents —CH(OR15)—, —C(?O)— or —C(?NOR15); R15 represents hydrogen, alkyl or phenyl; and R16 represents —CH3 or —CH2CH3; Z is alkyl, alkenyl, alkynyl, acyl, alkylalkoxy, aryl, alkanoyloxy, alkoxycarbonyl, alkenoyl, alkynoyl, or aroyl.Type: GrantFiled: May 3, 2007Date of Patent: April 5, 2011Assignee: Merial LimitedInventors: Mark D. Soll, Albert Boeckh, Natalya Shub
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Patent number: 7915010Abstract: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding R. sanguineus glutamate gated chloride channels, substantially purified forms of associated R. sanguineus glutamate gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Rhipicephalus sanguineus glutamate gated chloride channels, which will be useful as insecticides.Type: GrantFiled: January 5, 2007Date of Patent: March 29, 2011Assignee: Merial LimitedInventors: Jeffrey W. Warmke, Youfeng Yang, Doris F. Cully, Michel J. Hamelin
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Patent number: 7910112Abstract: The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing avian influenza antigens, epitopes or immunogens which can be used to protect animals, in particular felids, against avian influenza.Type: GrantFiled: November 6, 2006Date of Patent: March 22, 2011Assignee: Merial LimitedInventors: Hervé Poulet, Jean Christophe Audonnet, Michel Bublot, Jiansheng Yao
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Patent number: 7906311Abstract: A cotton rat cell line, uses of cotton rat cells for growing, propagating, or culturing organisms, pathogens or viruses, such as PRRSV, and uses of the resultant organisms, pathogens or viruses, are disclosed.Type: GrantFiled: March 18, 2003Date of Patent: March 15, 2011Assignee: Merial LimitedInventors: Frederic R. David, Sudhir K. Reddy, Michael E. Tanner
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Patent number: 7879897Abstract: The invention relates to 5-sub-stituted-oxyalkylaminopyrazole derivatives of the formula or salts thereof wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests including arthropods and helminths.Type: GrantFiled: August 21, 2004Date of Patent: February 1, 2011Assignee: Merial LimitedInventors: David Teh-Wei Chou, Stefan Schnatterer, Werner Knauf, Karl Seeger
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Patent number: 7872038Abstract: The invention relates to 1-(2,4,6-trisubstituted-phenyl)-5-amino-4-substituted-pyrazole derivatives of formula (I) or salts thereof wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).Type: GrantFiled: February 25, 2005Date of Patent: January 18, 2011Assignee: Merial LimitedInventors: Stefan Schnatterer, David Teh-Wei Chou, Werner Knauf, Daniela Jans, Karl Seeger