Patents Assigned to Meridian Biopharmaceuticals GmbH
  • COMBINATION OF TUMOR-ASSOCIATED SURFACE PROTEIN ANTIGENS AND TUMOR-ASSOCIATED SUGARS IN THE TREATMENT AND DIAGNOSIS OF CANCER
    Publication number: 20160000914
    Abstract: The invention relates to a kit for the combined use for the treatment of cancer patients, which set comprises an antigen of a cellular surface protein, or an antibody directed against the cellular surface protein, and an antigen of an aberrant glycosylation, or an antibody directed against the aberrant glycosylation. This kit is destined both for the immunotherapeutic and the diagnostic application. The invention further relates to a selection method for selecting suitable tumor-specific antigens with the assistance of this kit and corresponding specific antibody preparations.
    Type: Application
    Filed: September 15, 2015
    Publication date: January 7, 2016
    Applicants: GREENOVATION BIOTECH GMBH, MERIDIAN BIOPHARMACEUTICALS GMBH
    Inventors: Hans LOIBNER, Gottfried HIMMLER
  • Method of treating lewis Y-expressing tumors
    Patent number: 8323650
    Abstract: The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: December 4, 2012
    Assignees: Meridian Biopharmaceuticals GmbH, Greenovation Biotech GmbH
    Inventors: Manfred Schuster, Gottfried Himmler, Guenter Waxenecker, Geert C. Mudde, Manuela Loidl, Gerda Redl, Hans Loibner
  • N-GLYCOSYLATED ANTIBODY
    Publication number: 20110020331
    Abstract: The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
    Type: Application
    Filed: May 24, 2010
    Publication date: January 27, 2011
    Applicants: MERIDIAN BIOPHARMACEUTICALS GmbH, GREENOVATION BIOTECH GmbH
    Inventors: Manfred Schuster, Gottfried Himmler, Günter Waxenecker, Geert C. Mudde, Manuela Loidl, Gerda Redl, Hans Loibner
  • IMMUNOGENIC, MONOCLONAL ANTIBODY
    Publication number: 20100310551
    Abstract: The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
    Type: Application
    Filed: March 29, 2010
    Publication date: December 9, 2010
    Applicants: MERIDIAN BIOPHARMACEUTICALS GmbH, GREENOVATION BIOTECH GmbH
    Inventors: Hans LOIBNER, Günter WAXENECKER, Gottfried HIMMLER, Helmut ECKERT, Manfred SCHUSTER, Ralf KIRCHEIS
  • N-glycosylated antibody
    Patent number: 7759464
    Abstract: The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: July 20, 2010
    Assignees: Greenovation Biotech GmbH, Meridian Biopharmaceuticals GmbH
    Inventors: Manfred Schuster, Gottfried Himmler, Gunter Waxenecker, Geert C. Mudde, Manuela Loidl, Gerda Redl, Hans Loibner