Abstract: An autoinjector useful for, inter alia, providing an injection of liquid medicament is disclosed, which includes a needle depth adapter for achieving a desired injection depth.

Abstract: An auto-injector for dispensing a predetermined dose of medicament is disclosed. The auto-injector includes a needle cover operative to engage an injection site. The needle cover is configured to move from a retracted position prior to a medicament dispensing operation to an extended locked position after the medicament dispensing operation. Any residual activation force remaining after the medicament dispensing operation is contained within the auto-injector and is not directed to the needle cover, thus attenuating, if not eliminating, any kickback effect.

Abstract: A needle and hub assembly for automatic injectors includes a cap or skirt that has a forward surface interposed between and reinforced by first and second engaged hub portions. A needle is received in a contiguous channel formed in the two hub portions. Methods of forming the assembly include molding the first hub portion, placing the cap over the first hub portion, inserting the needle into the channel in the first hub portion, and then overmolding or otherwise forming the second hub portion on the exterior of the first hub portion and cap such that the second hub portion engages the first hub portion. An assembly created by this “two-shot” process can be used to seal a relatively large opening in a medicament cartridge and to support the needle more effectively than a conventional assembly.

Abstract: A cartridge assembly apparatus for an auto-injector includes a flexible container containing a liquid medicant. A needle hub is connected to the flexible container. A needle is attached to the needle hub and extends proximally from the needle hub. A frame is connected to the needle hub and includes a frame proximal end extending proximally beyond a proximal end of the needle. The needle hub and the needle are displaceable relative to the frame in a proximal direction to insert the needle into a patient.

Abstract: An auto-injector apparatus includes a flexible container containing a liquid medicant, a needle communicated with a container, a housing with a container being received in the housing, a pump disposed in the housing and positioned to engage the flexible container and expel the medicant from the container through the needle upon relative movement between the pump and the container, and a main drive spring operably associated with the needle to extend the needle from a first needle position wherein the needle is completely received in the housing to a second needle position wherein the needle protrudes from the housing. The pump may be a roller.

Abstract: A medicament container, medicament dispensing kit and packaging process that minimizes exposure of the medication to oxygen to prevent degradation of the medication are disclosed.

Abstract: A resettable training device and method for training a user on the operation of an auto-injector for dispensing a medicament are provided. The user can operate the training device to simulate an auto-injector operation and then reset the training device to repeat the injector operation. The training device includes a housing, a cover member slidably received within the housing between a retracted operative position and an extended inoperative position, a spring member for biasing the cover member into the extended position, an actuation assembly that controls the movement of the cover member from the retracted position to the extended position in response to activation of the trainer by the user, a safety pin, and in some embodiments at least one releasable locking assembly to prevent movement of the cover member from the extended position to the retracted position.

Abstract: An automatic injector separately stores liquid and dry components in respective compartments. When the injector is activated, a fluid-directing member between the liquid and dry compartments causes the liquid component to form a vortex as the liquid flows into the dry compartment. This allows the two components to combine more thoroughly and quickly to form a liquid solution that is delivered to an injection site.

Abstract: Containers for automatic injectors and automatic injectors adapted for those containers are disclosed. The containers include structures adapted to retain and, optionally, cripple the needle of the automatic injector when the automatic injector is inserted into the container after use. Depending on the embodiment, an indicator may be included, either as part of the container or as part of the automatic injector, to indicate whether or not the automatic injector has been used. If the indicator is provided as a part of the automatic injector, a corresponding portion of the container may be formed of a light permeable material. The container may also include features, such as an eyelet over the closed end, designed to cushion the automatic injector. Cushioning and shock absorbing features may also be provided inside the container. A clip is also disclosed. The clip is designed to attach two or more containers together.

Abstract: An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that has a plug that is moved from a sealing position into a mixing position when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert “funnels” the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle assembly allows for better flow through the filter. An actuation assembly drives the plug into the mixing position and forces the mixed medicament through the needle and into the user.

Abstract: An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition into a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.

Abstract: In one embodiment, an automatic injector comprises a cartridge adapted to contain a charge of medicament, a seal structure disposed toward a forward end of the cartridge, a plunger normally disposed in a generally rearward end of the cartridge and movable through the cartridge toward a generally forward end thereof in response to an actuating procedure. The movable plunger rearwardly confines the medicament within the cartridge. A needle normally disposed in communication with the medicament container provides a passage in which the medicament is released into an individual's flesh in response to an actuating procedure projecting the needle into the flesh of the individual. The cartridge having an increased friction region so as to slow the motion of the plunger when the forward end of the needle travels through the seal in order to eliminate coring.

Abstract: A separation assembly for initially keeping a first component separate from a second component includes a generally cylindrical body slidably supported within a container between the first and second components. The body includes a seal structure having an inner seal member that initially seals the first component from the second component. In response to a predetermined operating condition, the inner seal member allows the first component to flow through at least one flow path in the seal structure to mix with the second component. The body further includes a flow distributing member disposed adjacent the seal structure to evenly distribute the first component into the second component. The seal structure and the flow distributing member form a single unit.

Abstract: A needle and hub assembly for an automatic injector and a method for making the needle and hub assembly. The needle and hub assembly comprises a cap or skirt, a forward surface of which is interposed between and reinforced by first and second engaged hub portions. A needle is received in a contiguous channel formed in the two hub portions. The method for making the assembly comprises molding the first hub portion, placing the cap over the first hub portion, inserting the needle into a channel in the first hub portion, and then overmolding or otherwise forming the second hub portion on the exterior of the cap such that it is engaged with the first hub portion. An assembly created by this “two-shot” process can be used to seal a relatively large opening, and supports the needle more effectively than a conventional assembly.

Abstract: An auto-injector for dispensing a predetermined dose of medicament is disclosed. The auto-injector includes a needle cover that is configured to move from a retracted position to an extended locked position. The auto-injector includes a first locking assembly to hold the needle cover in a locked retracted position and a second locking assembly to hold the needle cover in a locked extended position.

Abstract: A protective package for a medicament dispenser has an inner protective layer and an outer chemical barrier layer. The protective package also includes at least one reinforcing layer secured to the outer chemical barrier layer. At least one light inhibiting layer is further provided to limit the transmission of light through the package.

Abstract: An auto-injector for dispensing a predetermined dose of medicament is disclosed. The auto-injector includes a needle cover that is configured to move from a retracted position to an extended locked position. The auto-injector includes a first locking assembly to hold the needle cover in a locked retracted position and a second locking assembly to hold the needle cover in a locked extended position.