Abstract: A valvuloplasty balloon catheter (100) is disclosed. The valvuloplasty balloon catheter (100) comprises of an inflatable member (40) having anchor shaped ends and a tubular member (50). The tubular member (50) comprises of a proximal section (50a), a distal section (50b) and a middle section (50c). The middle section (50c) includes a proximal middle portion (50c1), a distal middle portion (50c2) and an intermediate portion (50c3). The proximal middle portion (50c1) and the distal middle portion (50c2) includes a plurality of closed cells (54). At least one of the proximal section (50a) or the distal section (50b) includes a plurality of first struts (52) being anchor shaped. The plurality of closed cells (54) includes one or more zig-zag elements being placed over tapered end of the inflatable member (40) thereby allowing uniform and smooth expansion of the tubular member (50). The intermediate portion 50c3 includes a plurality of s-shaped links.

Abstract: A device and method of radially collapsing a medical device is disclosed. The device is in the form of an improved crimper which is capable of crimping a medical device. The crimper includes without limitation one or more of, a base plate, a stopper, two side plates, two housing plates with a handle, a plurality of jaws, two guide plates, at least one gear ring and a plurality of gear pins. The jaws, when assembled, collectively form an iris opening. The assembly of the crimper has a central opening through which the iris opening can be accessed. The device to be crimped is introduced in the central opening and held within the iris opening. The crimping is achieved by reducing the size of the iris opening (by moving the jaws simultaneously with respect to each other in synchronized manner) which in turn reduces the diameter of the prosthetic device.

Abstract: A method for implanting a prosthetic valve in a patient's body with minimum misalignment of commissures of the prosthetic valve to the commissures of a native aortic valve is disclosed. AoCA of a native aortic valve of a patient to be treated is determined and the prosthetic valve having three commissures is crimped on a delivery system having one or more aligners marked on its outer shaft. The aligners follow same axis. Crimping is done using a crimper and/or a confirmation gauge that includes one or more angle markings. Crimping is performed such that one of the commissures of the prosthetic valve is axially aligned with the AoCA identified on the angle markings on one of the crimper/confirmation gauge and at the same time, the one or more aligners face upwards. The crimped prosthetic valve is implanted by maintaining the aligner(s) pointing upward during the entire implantation procedure.

Abstract: A radially expandable and collapsible prosthetic aortic valve suitable for mounting on a balloon of a delivery catheter in a radially collapsed condition is disclosed. The prosthetic aortic valve includes a support frame having three circumferentially extending rows of angled struts. Any two consecutive angled struts of a row of circumferentially extending angled struts form a peak/a valley. The adjacent rows of angled struts are connected to each other by links (either a diamond shaped cell or a rhombus body, thereby forming two rows of cells. The prosthetic aortic valve includes three leaflets, an internal skirt and an external skirt. The support frame and the delivery catheter provide an easy and accurate method for deployment of the prosthetic aortic valve at a target location.

Abstract: There is disclosed a process for treatment to avert enzymatic degradation and tissue degeneration of bovine pericardium tissue, used for making bioprosthesis for implant application, comprising the steps of collecting and harvesting raw bovine pericardial tissue; chemically cross-linking the rinsed tissue to generate fixed tissue; laser cutting said fixed tissue to produce tissue leaflet; chemically treating said tissue leaflet with AAS; chemically sterilising and storing the fixed bovine pericardium tissue to maintain the structural integrity and characteristics; and wherein all the above steps are carried out in a low-oxygen and controlled temperature environment.

Abstract: A prosthetic heart valve assembly is disclosed. The said assembly includes a prosthetic heart valve (10). The said valve (10) is mounted over a balloon (5) for deployment at a target location. The dimensions of the said valve (10) mimic the anatomy of a native heart valve. The delivery catheter (100) is used for deployment of the prosthetic heart valve (10). The delivery catheter (100) includes a handle (11), a multi-layered outer shaft (1) and/or an inner shaft (3) including an inner second end (3b). A support tube (7) is disposed on top of the inner second end (3b) and includes one or more holes (7a) for passing an inflation fluid and is provided with the balloon (5) on its outer surface. One or stoppers (9) are provided on the support tube (7) and within the balloon (5) and include a first portion (C) and a second portion (D).

Abstract: A vascular closure system is configured to seal an incision in a vessel of the patient's body. The system includes a slider that is moved from an initial position to a deployed position (that is, towards the puncture of the patient body), until the proximal end of the slider exposes a reference marker on an inner tube. This confirms the deployment of the closure element and completely expands or opens or pivots the closure element in the blood vessel.

Abstract: This invention discloses a process for preparation of a balloon expandable biodegradable polymer stent with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength. The invention discloses a process for the preparation of a biodegradable polymer stent which involves radially deforming the biodegradable polymer tube by applying pressure to it with an inert gas at a predefined temperature in multiple stages with each successive stage having a pressure higher than the pressure applied in a previous stage. The process further involves maintaining the predefined temperature and pressure conditions of each stage for a specified time period after application of the pressure.

Abstract: This invention discloses a process for preparation of a balloon expandable biodegradable polymer stent with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength. The invention discloses a process for the preparation of a biodegradable polymer stent which involves deforming an extruded biodegradable polymer tube axially at a first predefined temperature by applying an axial force for a first predefined time interval. The process further includes radially expanding the axially stretched tube at a second predefined temperature by pressurizing the tube with an inert gas in one or more stages, the pressure applied in each successive stage being higher than the pressure applied in a previous stage.

Abstract: The invention discloses a process for the preparation of a biodegradable stent which involves deforming an extruded biodegradable polymer tube axially at a first predefined temperature by applying an axial force for a first predefined time interval. The process is followed by radially expanding the axially stretched tube at a second predefined temperature by pressurizing the tube with an inert gas in one or more stages, the pressure applied in each successive stage being higher than the pressure applied in a previous stage. The process further comprises laser cutting a specific pattern of scaffold structure on the expanded tube and then crimping the laser cut stent on the balloon of delivery catheter in a sterile environment in multiple stages.

Abstract: This invention discloses method of manufacture of balloon expandable stent made from bioabsorbable polymer with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength. The invention further discloses balloon expandable stent made from bioabsorbable polymer with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength.

Abstract: A vascular closure system is configured to seal an incision in a vessel of the patient's body. The system includes a slider that is moved from an initial position to a deployed position (that is, towards the puncture of the patient body), until the proximal end of the slider exposes a reference marker on an inner tube. This confirms the deployment of the closure element and completely expands or opens or pivots the closure element in the blood vessel.

Abstract: This invention discloses method of manufacture of balloon expandable stent made from bioabsorbable polymer with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength. The invention further discloses balloon expandable stent made from bioabsorbable polymer with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength.

Abstract: The invention discloses novel 42-0-(heteroalkoxyalkyl) rapamycin compounds of formula (1) and process for preparation thereof. These compounds are useful in the treatment of hyperproliferative vascular diseases such as restenosis and atherosclerosis Wherein, R denotes 3, 4 and 5 membered 3-hydroxy heteroalkoxyalkyl compounds selected from Tetrahydrofuran-3-ol, Oxetan-3-ol, Tetrahydropyran-3-ol, Tetrahydro-4- methyl furan-3-ol, Tetrahydro-2,5,5-trimethyl furan-3-ol, Tetrahydro-2,5-diethyl-2-methyl furan-3-ol, Tetrahydro-6-methoxy-2-methyl 2H-Pyran-3-ol and Tetrahydro-2,2-dimethyl-6-phenyl 2H-Pyran-3-ol.