Abstract: Compounds represented by formula I:
as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.
Type:
Grant
Filed:
March 16, 2000
Date of Patent:
May 1, 2001
Assignee:
Merk Frosst Canada & Co.
Inventors:
Yongxin Han, Andre Giroux, Erich Grimm, Renee Aspiotis, Sebastien Francoeur, Robert Zamboni, Petpiboon Prasit, Christopher Bayly, Dan McKay, Cameron Black