Abstract: The present invention is directed to a method of using a certain compounds which are 2,19-methyleneoxy or 2,19 methylenethio bridged steroids, and related steroidal compounds as inhibitors of the enzyme steroid aromatase, 19-hydroxylase and as treatment for various estrogen dependent/mediated disorders including hormonal dependent breast cancer.
Type:
Grant
Filed:
October 26, 1999
Date of Patent:
November 6, 2001
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Norton P. Peet, J. O'Neal Johnston, Joseph P. Burkhart
Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula 1
Type:
Application
Filed:
December 8, 2000
Publication date:
September 13, 2001
Applicant:
Merrell Pharmaceuticals Inc.
Inventors:
Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hax, Duane E. Rudisill, Gianbattista Panzone
Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula 1
Type:
Application
Filed:
November 29, 2000
Publication date:
September 6, 2001
Applicant:
Merrell Pharmaceuticals Inc.
Inventors:
Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula 1
Type:
Application
Filed:
November 29, 2000
Publication date:
August 30, 2001
Applicant:
Merrell Pharmaceuticals Inc.
Inventors:
Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
Abstract: This invention relates to novel morpholinourea and related derivatives of pentafluoroethyl peptides which are orally active elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases and emphysema.
Type:
Grant
Filed:
January 28, 2000
Date of Patent:
July 24, 2001
Assignee:
Merrell Pharmaceuticals, Inc.
Inventors:
Norton P. Peet, Michael R. Angelastro, Joseph P. Burkhart
Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula
wherein
W represents —C(═O)— or —CH(OH)—;
R1 represents hydrogen or hydroxy;
R2 represents hydrogen;
R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;
n is an integer of from 1 to 5;
m is an integer 0 or 1;
R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched;
each of A is hydrogen or hydroxy; and
pharmaceutically acceptable salts and individual optical isomers thereof,
with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.
Type:
Grant
Filed:
July 14, 1994
Date of Patent:
June 5, 2001
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
Abstract: The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of the formula
wherein
R1 is hydrogen or hydroxy;
R2 is hydrogen;
or R1 and R2 taken together form a second bond between
the carbon atoms bearing R1 and R2;
n is an integer of from 1 to 5;
R3 is —COOH or —COOalkyl wherein the alkyl moiety has
from 1 to 6 carbon atoms and is straight or branched;
each of A and B is hydrogen or hydroxy with the proviso
that at least one of A or B is hydrogen;
or a pharmaceutically acceptable salt and individual isomers thereof.
Type:
Grant
Filed:
January 12, 2000
Date of Patent:
February 13, 2001
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
James K. Woodward, Richard A. Okerholm, Mark G. Eller, Bruce E. McNutt
Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hydrogen;R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;n is an integer of from 1 to 5;m is an integer 0 or 1;R.sub.3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R.sub.1 and R.sub.2 are ta to form a second bond between the carbon R.sub.1 and R.sub.2 or where R.sub.1 represented hydroxy integer 0.
Type:
Grant
Filed:
June 2, 1995
Date of Patent:
November 14, 2000
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
Abstract: A method for inhibiting the formation of glucose by the administration of castanospermine is described herein. In addition, a new process for the isolation of castanospermine from Castanospermum australe is also described.
Abstract: The present invention provides novel compounds such as certain aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake. The present invention also provides an improvement in the treatment of depression which comprises inhibiting synaptic serotonin and epinepherine uptake.
Abstract: This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
Type:
Grant
Filed:
August 24, 1998
Date of Patent:
October 10, 2000
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
H. Michael Kolb, Joseph P. Burkhart, Michael J. Jung, Fritz E. Gerhart, deceased, Eugene L. Giroux, Bernhard Neises, Daniel G. Schirlin
Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.
Type:
Grant
Filed:
September 8, 1997
Date of Patent:
September 5, 2000
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
Abstract: The present invention relates to polyamine derivatives of the formula RHN-(CH.sub.2).sub.m -NH-(CH.sub.2).sub.n -NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C.sub.2 -C.sub.6 alkyl or --(CH.sub.2).sub.p -Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof which are useful as radioprotective agents. It relates also to the use of polyamines of the formula RHN-(CH.sub.2).sub.m -NH-(CH.sub.2).sub.n -NH-(CH.sub.2).sub.m -NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C.sub.2 -C.sub.6 alkyl or --(CH.sub.2).sub.p -Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof as radioprotective agents.
Abstract: The present invention relates to cyclic peptide analogs containing a pseudo-bond, useful as platelet aggregation inhibitors. An example of a compound of this invention includes Cyclo[Ala.PSI.[CH.sub.2 NH]-Arg-Gly-Asp-.delta.-Glu](NHBn).cndot.CF.sub.3 CO.sub.2 H. These compounds inhibit the binding of fibrinogen to the platelet GPIIb-IIIa integrin receptor which inhibits platelet aggregation and therefore these compounds act as potent antithrombotics.
Abstract: The oligomers of the present invention are polythioureas having 3 to 50 recurring units derived from aromatic diamines substituted with anionic groups, and having a number average molecular weight of less than 10,000. These oligomers are water-soluble, preferably have a rigid backbone, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of AIDS.
Type:
Grant
Filed:
November 26, 1997
Date of Patent:
July 11, 2000
Assignees:
Merrell Pharmaceuticals Inc., The Dow Chemical Co.
Inventors:
Michael J. Mullins, William A. Fordyce, William J. Kruper, Norton P. Peet, Alan D. Cardin
Abstract: The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.
Type:
Grant
Filed:
April 1, 1997
Date of Patent:
January 11, 2000
Assignees:
The Dow Chemical Co., Merrell Pharmaceuticals Inc.
Inventors:
Alan D. Cardin, William A. Fordyce, Michael J. Mullins, Thomas A. Chamberlin, Michael J. Fazio
Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
Type:
Grant
Filed:
November 13, 1998
Date of Patent:
December 21, 1999
Assignee:
Merrell Pharmaceuticals, Inc.
Inventors:
Albert A. Carr, John M. Kane, David A. Hay
Abstract: The present invention provides 4-nitro-.DELTA..sup.4 -3-ketosteroids, their use as steroid C.sub.17-20 lyase and 5.alpha.-reductase inhibitors and to a novel process for preparing a compound of the formula: ##STR1## comprising sequentially: a) reacting a starting compound of the formula ##STR2## with an effective amount of a strong base at an elevated or suitable temperature for a time sufficient to create the corresponding thermodynamic dienolate, followed by addition of a neutral nitrating agent to produce the 4-nitrosteroid; and then;b) reacting the 4-nitrosteroid with a suitable reducing agent.
Type:
Grant
Filed:
February 24, 1999
Date of Patent:
November 23, 1999
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Philip M. Weintraub, Michael R. Angelastro, Cynthia A. Gates, Gary Alan Flynn, Timothy Thomas Curran, Chi-Hsin Richard King