Abstract: Dipeptide compounds and analogs thereof having a phosphonomethyl moiety are disclosed. These compounds inhibit Endothelin Converting Enzyme and are thus useful in treating conditions responsive to inhibition of production of Endothelin.
Abstract: This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
Type:
Grant
Filed:
November 1, 1994
Date of Patent:
March 4, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Donald P. Matthews, Alan J. Bitonti, Michael L. Edwards, James R. McCarthy
Abstract: The preferred oligomers of the present invention are polyureas having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. These oligomers are prepared by reacting an aromatic diamine with a difunctional electrophile, in the presence of an acid acceptor, in water as the solvent or water with up to about 1 mole of water immiscible cosolvent, at a temperature of from 0.degree. to 100.degree. C. and at a pH between about 7 to about 9. The oligomers are useful for the treatment and/or diagnosis of AIDS and ARC.
Type:
Grant
Filed:
October 6, 1993
Date of Patent:
February 25, 1997
Assignees:
Merrell Pharmaceuticals Inc., The Dow Chemical Co.
Abstract: The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.
Type:
Grant
Filed:
December 12, 1995
Date of Patent:
February 18, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John H. Kehne
Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
February 11, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
Abstract: The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.
Type:
Grant
Filed:
October 26, 1995
Date of Patent:
February 11, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Gary A. Flynn, John F. French, Richard C. Dage
Abstract: The present invention relates to novel substituted alkyldiamine derivatives and pharmaceutically acceptable salts thereof which are useful tachykinin antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions including asthma, cough, and bronchitis.
Type:
Grant
Filed:
June 20, 1994
Date of Patent:
January 28, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le
Abstract: The present invention relates to a method of treating a patient afflicted with a neoplastic disease state comprising the administration thereto of an effective antineoplastic amount of ionizing or nonionizing radiation, or an effective antineoplastic amount of a DNA-reactive chemotherapeutic agent in conjunctive therapy with an effective sensitizing amount of a compound of formula (I).
Abstract: Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
January 21, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Albert A. Carr, John M. Kane, George D. Maynard, Hsien C. Cheng, Mark W. Dudley
Abstract: The present invention relates to the use of certain anionic polyamide and polyurea oligomers for inhibiting angiogenesis, and for their use in treating diseases associated with angiogenesis. These oligomers have a number average molecular weight (M.sub.n) less than 10,000, comprise recurring units coupled by carbonyl linking moieties and have predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium. The oligomers also have a preferably linear backbone and be be in their salt form, preferably wherein the salt is pharmaceutically acceptable.
Abstract: The present invention is directed toward a novel process of preparing 2'-exocyclic vinylfluoride derivatives of cytidine analogues for use as ribonucleotide reductase inhibitors. The novel process of the present invention utilizes a cytidine derivative as the required starting material and provides the ribonucleotide reductase inhibitor in a more efficient than the reaction sequence. The process is more efficient than the process disclosed by McCarthy et al. in European Patent Application Publication No. 0 372 268 published Jun. 13, 1990, in that it requires fewer chromatographies and results in an overall yield of greater than 25% for the five steps. The present invention further provides the ribonucleotide reductase inhibitor in a four step reaction sequence and results in an overall yield of greater than 35%.
Type:
Grant
Filed:
April 10, 1995
Date of Patent:
December 31, 1996
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
James R. McCarthy, Donald P. Matthews, Jeffrey S. Sabol, James R. McConnell, Richard E. Donaldson, Robert Duquid
Abstract: The preferred oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geomentry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of AIDS and ARC.
Type:
Grant
Filed:
May 19, 1995
Date of Patent:
November 5, 1996
Assignees:
The Dow Chemical Company, Merrell Pharmaceuticals Inc.
Inventors:
Alan D. Cardin, Richard L. Jackson, Michael J. Mullins
Abstract: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
Type:
Grant
Filed:
March 2, 1995
Date of Patent:
October 22, 1996
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Gary A. Flynn, Douglas W. Beight, Alan M. Warshawsky, Shujaath Mehdi, John F. French, John H. Kehne
Abstract: This invention relates to novel polyfluorinated alkyl derivatives of certain tripeptides, to the methods for their preparation, the intermediates therefore, to their use in inhibiting thrombin and lung tryptase and in their end-use application as anti-coagulants useful in treating thrombophlebitis and coronary thrombosis and in the treatment of asthma.
Type:
Grant
Filed:
May 19, 1995
Date of Patent:
October 8, 1996
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Bernhard Neises, Axel Ganzhorn, C eline Tarnus, Robert J. Broersma, Jr.
Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
Type:
Grant
Filed:
January 13, 1995
Date of Patent:
October 1, 1996
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
Abstract: The present invention provides novel aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake.
Abstract: The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive therapy with an effective antineoplastic amount of a cytotoxic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite and an antineoplastic platinum coordination complex, wherein a synergistic antineoplastic effect results.