Patents Assigned to Merrion Research III Limited
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Patent number: 9089484Abstract: The present invention provides pharmaceutical compositions for oral administration comprising a therapeutically effective amount of a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid or a salt, ester, ether, or derivative of a medium chain fatty acid and has a carbon chain length of from about 4 to about 20 carbon atoms. The present invention also provides a method for obtaining a reproducible bioavailability of selective factor Xa inhibitor in an object after oral administration comprising orally administering a pharmaceutical composition as described above.Type: GrantFiled: March 28, 2011Date of Patent: July 28, 2015Assignee: Merrion Research III LimitedInventors: Thomas W. Leonard, David C. Coughlan, Alan Cullen
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Patent number: 8999383Abstract: The present invention provides compositions of GnRH related compounds that are suitable for oral administration, injectable administration and other forms of administration wherein the gelling characteristics of the composition are a factor. The compositions of the present invention comprise a therapeutically effective amount of one or more GnRH related compound, and a sufficient amount of at least one anti-gelling agents to reduce the gelation of the GnRH related compound. The present invention also provides processes for preparation of a composition of one or more GnRH related compound, wherein the process comprises mixing the GnRH related compound with one or more anti-gelling agents, wherein the anti-gelling agent comprises a medium chain fatty acid salt, or an ester, an ether, or a derivative of a medium chain fatty acid and has a carbon chain length of from about 4 to about 20 carbon atoms or is a surface active agent.Type: GrantFiled: May 7, 2009Date of Patent: April 7, 2015Assignee: Merrion Research III LimitedInventors: Amanda Lee, Bozena Adamczyk, David C. Coughlan, Edel O'Toole, Thomas W. Leonard
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Patent number: 8883203Abstract: The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to enhance intestinal delivery of the bisphosphonate to the underlying circulation. Preferably, the enhancer is a medium chain fatty acid or a medium chain fatty acid derivative having a carbon chain length of from 6 to 20 carbon atoms, and the solid oral dosage form is a controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: April 26, 2010Date of Patent: November 11, 2014Assignee: Merrion Research III LimitedInventor: Thomas W. I. Leonard
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Patent number: 8883201Abstract: The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to enhance intestinal delivery of the bisphosphonate to the underlying circulation. Preferably, the enhancer is a medium chain fatty acid or a medium chain fatty acid derivative having a carbon chain length of from 6 to 20 carbon atoms, and the solid oral dosage form is a controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: June 10, 2009Date of Patent: November 11, 2014Assignee: Merrion Research III LimitedInventor: Thomas W. I. Leonard
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Patent number: 8828431Abstract: The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug and an enhancer wherein the enhancer is a medium chain fatty acid ester, ether or salt or a derivative of a medium chain fatty acid, which is, preferably, solid at room temperature and which has a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: November 30, 2012Date of Patent: September 9, 2014Assignee: Merrion Research III LimitedInventors: Kenneth Iain Cumming, Zebunnissa Ramtoola
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Patent number: 8802114Abstract: The present invention generally relates to orally administered pharmaceutical compositions of iron compounds with medium chain fatty acid salts. The invention further relates to methods of using the pharmaceutical compositions to treat iron deficiency and related disorders.Type: GrantFiled: January 6, 2012Date of Patent: August 12, 2014Assignee: Merrion Research III LimitedInventors: Alan Cullen, Edel O'Toole, David C. Coughlan, Kishore Chalasani, Thomas W. Leonard
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Patent number: 8753683Abstract: A solid pharmaceutical composition comprising a water-soluble bioactive material and an encapsulating material which is present in the composition in the form of continuous solid phase, and in which solid particles of the bioactive material are dispersed and encapsulated in the continuous solid phase of the encapsulating material, wherein each of the bioactive material and the encapsulating material is normally a solid at room temperature and the melting point of the encapsulating material is lower than the melting point of the bioactive material, the bioactive material being preferably a bisphosphonate, most preferably alendronate, and the encapsulating material includes an enhancer, preferably a mono- or di-glyceride, or an encapsulating surfactant, preferably a polyoxyethylene/polyoxypropylene block copolymer having surface active properties, and a process for preparing the composition in which solid particles of the bioactive material are mixed with and dispersed in the encapsulating material which is inType: GrantFiled: January 22, 2010Date of Patent: June 17, 2014Assignee: Merrion Research III LimitedInventors: Maurice Joseph Anthony Clancy, K. Iain Cumming, Conor B. Mc Crystal
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Patent number: 8323689Abstract: The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug and an enhancer wherein the enhancer is a medium chain fatty acid ester, ether or salt or a derivative of a medium chain fatty acid, which is, preferably, solid at room temperature and which has a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: July 14, 2008Date of Patent: December 4, 2012Assignee: Merrion Research III LimitedInventors: Kenneth I. Cumming, Zebunnissa Ramtoola
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Patent number: 8323690Abstract: The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug and an enhancer wherein the enhancer is a medium chain fatty acid ester, ether or salt or a derivative of a medium chain fatty acid, which is, preferably, solid at room temperature and which has a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: April 27, 2010Date of Patent: December 4, 2012Assignee: Merrion Research III LimitedInventors: Kenneth I. Cumming, Zebunnissa Ramtoola
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Patent number: 8119159Abstract: The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to promote absorption of the bisphosphonate at the GIT cell lining. The enhancer is a medium chain fatty acid or a medium chain fatty acid derivative having a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is a controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: April 7, 2006Date of Patent: February 21, 2012Assignee: Merrion Research III LimitedInventors: Kenneth Iain Cumming, Zebunissa Ramtoola, Thomas Waymond Leonard
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Patent number: 8053429Abstract: The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug and an enhancer wherein the enhancer is a medium chain fatty acid ester, ether or salt or a derivative of a medium chain fatty acid, which is, preferably, solid at room temperature and which has a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: September 3, 2009Date of Patent: November 8, 2011Assignee: Merrion Research III LimitedInventors: Kenneth I. Cumming, Zebunnissa Ramtoola
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Patent number: 8033083Abstract: An improved automated process and apparatus for making a gastro-retentive device (10). The method includes the steps of providing a pouch assembly (18) having an ingredient section within a membrane; rotating the membrane to form a folded pouch assembly; inserting the folded pouch assembly into a first capsule section (20a) to form a pouch/first capsule assembly, and inserting the pouch/first capsule assembly into a second capsule section (20b). The process can further include the steps of providing a continuous strip (32) of multiple pouch assemblies (18) and cutting a single pouch assembly (18) from the strip (32).Type: GrantFiled: January 15, 2010Date of Patent: October 11, 2011Assignee: Merrion Research III LimitedInventor: Jagathesan Moodley
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Patent number: 8017727Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.Type: GrantFiled: December 23, 2009Date of Patent: September 13, 2011Assignee: Merrion Research III LimitedInventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
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Patent number: 7997049Abstract: A process and apparatus for making a gastro-retentive device (10). The method includes the steps of providing a pouch assembly having an ingredient section within a membrane; folding the membrane to form a folded pouch assembly; inserting the folded pouch assembly into a first capsule section (20a) to form a pouch/first capsule assembly, and inserting the pouch/first capsule assembly into a second capsule section (20b). Also provided is an apparatus (38) for carrying out the above method which includes a tooling block (44) having a passageway (62) configured for slidable movement of the pouch assembly (18) therein, and a tooling pocket (60) extending from a top surface of the tooling block to the passageway and which receives the pouch assembly. A ram (86) is provided for pushing the pouch assembly through the tooling pocket into the passageway, wherein the pouch assembly is folded and encapsulated.Type: GrantFiled: March 4, 2009Date of Patent: August 16, 2011Assignee: Merrion Research III LimitedInventor: Jagathesan Moodley
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Patent number: 7820722Abstract: A pharmaceutical composition comprising a drug and a permeation enhancer that comprises a multi-carbon backbone having a functional group and also one or more side chains which have one or more carbon atoms and, optionally, one or more functional groups.Type: GrantFiled: May 13, 2002Date of Patent: October 26, 2010Assignee: Merrion Research III LimitedInventors: Araz A. Raoof, Mangaraju Gudipati
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Patent number: 7704977Abstract: The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to enhance intestinal delivery of the bisphosphonate to the underlying circulation. Preferably, the enhancer is a medium chain fatty acid or a medium chain fatty acid derivative having a carbon chain length of from 6 to 20 carbon atoms, and the solid oral dosage form is a controlled release dosage form such as a delayed release dosage form.Type: GrantFiled: April 9, 2007Date of Patent: April 27, 2010Assignee: Merrion Research III LimitedInventor: Thomas W. I. Leonard
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Patent number: 7669388Abstract: An improved automated process and apparatus for making a gastro-retentive device (10). The method includes the steps of providing a pouch assembly (18) having an ingredient section within a membrane; rotating the membrane to form a folded pouch assembly; inserting the folded pouch assembly into a first capsule section (20 a) to form a pouch/first capsule assembly, and inserting the pouch/first capsule assembly into a second capsule section (20 b). The process can further include the steps of providing a continuous strip (32) of multiple pouch assemblies (18) and cutting a single pouch assembly (18) from the strip (32).Type: GrantFiled: August 1, 2005Date of Patent: March 2, 2010Assignee: Merrion Research III LimitedInventor: Jagathesan Moodley
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Patent number: 7670626Abstract: A solid pharmaceutical composition comprising a water-soluble bioactive material and an encapsulating material which is present in the composition in the form of continuous solid phase, and in which solid particles of the bioactive material are dispersed and encapsulated in the continuous solid phase of the encapsulating material, wherein each of the bioactive material and the encapsulating material is normally a solid at room temperature and the melting point of the encapsulating material is lower than the melting point of the bioactive material, the bioactive material being preferably a bisphosphonate, most preferably alendronate, and the encapsulating material includes an enhancer, preferably a mono- or di-glyceride, or an encapsulating surfactant, preferably, a polyoxyethylene/polyoxypropylene block copolymer having surface active properties, and a process for preparing the composition in which solid particles of the bioactive material are mixed with and dispersed in the encapsulating material which is inType: GrantFiled: July 2, 2002Date of Patent: March 2, 2010Assignee: Merrion Research III LimitedInventors: Maurice Joseph Anthony Clancy, K. Iain Cumming, Conor B. McCrystal
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Patent number: 7638599Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.Type: GrantFiled: December 16, 2005Date of Patent: December 29, 2009Assignee: Merrion Research III LimitedInventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
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Patent number: 7513091Abstract: An automated process and apparatus for making a gastro-retentive device (10). The method includes the steps of providing a pouch assembly having an ingredient section within a membrane; folding the membrane to form a folded pouch assembly; inserting the folded pouch assembly into a first capsule section (20a) to form a pouch/first capsule assembly, and inserting the pouch/first capsule assembly into a second capsule section (20b). The process can further include the steps of providing a strip (32) of multiple pouch assemblies (18) and cutting a single pouch assembly from the strip (32). Also provided is an apparatus (38) for carrying out the above method which includes a tooling block (44) having a passageway (62) configured for slidable movement of the pouch assembly (18) therein, and a tooling pocket (60) extending from a top surface of the tooling block to the passageway and which receives the pouch assembly.Type: GrantFiled: July 30, 2004Date of Patent: April 7, 2009Assignee: Merrion Research III LimitedInventor: Jagathesan Moodley