Abstract: Provided are methods for efficiently and comprehensively screening antibody repertoires from B cells to obtain and produce molecules with binding characteristics and functional activities for use in human therapy.
Type:
Grant
Filed:
September 26, 2012
Date of Patent:
September 29, 2015
Assignee:
MERUS BIOPHARMACEUTICALS B.V.
Inventors:
Mark Throsby, Ton Logtenberg, John De Kruif
Abstract: Provided are methods for efficiently and comprehensively screening antibody repertoires from B cells to obtain and produce molecules with binding characteristics and functional activities for use in human therapy.
Abstract: The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. The invention further provides a method for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, the at least two proteinaceous molecules having different binding specificities, comprising paired variable regions, at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from the pairing.
Type:
Grant
Filed:
November 30, 2005
Date of Patent:
April 5, 2011
Assignee:
Merus Biopharmaceuticals, B.V.i.o.
Inventors:
Hendricus Renerus Jacobus Mattheus Hoogenboom, Ton Logtenberg
Abstract: The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. The invention further provides a method for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, the at least two proteinaceous molecules having different binding specificities, comprising paired variable regions, at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from the pairing.
Type:
Application
Filed:
November 30, 2005
Publication date:
July 20, 2006
Applicant:
Merus Biopharmaceuticals, B.V. i.o.
Inventors:
Hendricus Mattheus Hoogenboom, Ton Logtenberg
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