Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
Type:
Grant
Filed:
November 2, 2010
Date of Patent:
May 13, 2014
Assignee:
Meso Scale Technologies LLP
Inventors:
Jacob N. Wohlstadter, James L. Wilbur, George B. Sigal, Mark T. Martin, Liang-Hong Guo, Alan Fischer, Jon Leland, Mark A. Billadeau, Larry R. Helms, Ramin Darvari
Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
Type:
Application
Filed:
November 2, 2010
Publication date:
May 26, 2011
Applicant:
MESO SCALE TECHNOLOGY LLP
Inventors:
Jacob N. WOHLSTADTER, James L. Wilbur, George B. Sigal, Mark T. Martin, Liang-Hong Guo, Alan Fischer, Jon Leland, Mark A. Billadeau, Larry R. Helms, Ramin Darvari
Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
Type:
Grant
Filed:
October 31, 2005
Date of Patent:
November 2, 2010
Assignee:
Meso Scale Technology LLP
Inventors:
Jacob N. Wohlstadter, James Wilbur, George Sigal, Mark Martin, Liang-Hong Guo, Alan Fischer, Jon Leland, Mark A. Billadeau, Larry R. Helms, Ramin Darvari
Abstract: The present invention relates to methods, reagents and compositions for conducting electrochemiluminescence binding assays which improve one or more characteristics of the assay or the instruments used to conduct the assay. The method is achieved using microparticles that include electrically conductive material. The electrically conductive material has one or more copies of an assay ligand immobilized an its outer surface and a plurality of electrochemiluminescent moieties immobilized an its outer surface. The assay ligand may be linked to the electrochemiluminescent moiety.
Type:
Application
Filed:
June 29, 2001
Publication date:
January 2, 2003
Applicant:
Meso Scale Technology LLP
Inventors:
George B. Sigal, Jacob N. Wohlstadter, Satyanarayana Gudibande, Mark T. Martin, James L. Wilbur
Abstract: Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
Type:
Application
Filed:
December 5, 2001
Publication date:
July 4, 2002
Applicant:
Meso Scale Technology LLP
Inventors:
Richard J. Massey, Mark T. Martin, Liwen Dong, Ming Lu, Alan Fischer, Fabian Jameison, Pam Liang, Robert Hoch, Jonathan K. Leland
Abstract: The present invention relates to methods, reagents and compositions, for conducting electrochemiluminescence binding assays which improve one or more characteristics of the assay or the instruments used to conduct the assay. The method is achieved using microparticles that include electrically conductive material. The electrically conductive material has one or more copies of an assay ligand immobilized an its outer surface and a plurality of electrochemiluminescent moieties immobilized an its outer surface. The assay ligand may be linked to the electrochemiluminescent moiety.
Type:
Grant
Filed:
December 23, 1997
Date of Patent:
November 20, 2001
Assignee:
Meso Scale Technology LLP
Inventors:
George B. Sigal, Jacob N. Wohlstadter, Satyanarayana Gudibande, Mark T. Martin, James L. Wilbur
Abstract: Recent advances in surface techniques have lead to the development of extremely small (sub-micron) scale features. These techniques allow the formation of polymer micro-lenses as well as variable focus liquid lenses. The present invention primarily concerns the use of small scale lenses for the fabrication of novel displays which exhibit three-dimensional (3D) effects. Both still images and video images (or other motion images) can be generated.