Patents Assigned to Mesoblast, Inc.
  • Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
    Patent number: 12275801
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: April 15, 2025
    Assignee: MESOBLAST, INC.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, John Paul Simmons
  • Methods of generating, repairing and/or maintaining connective tissue in vivo
    Patent number: 12220433
    Abstract: This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: February 11, 2025
    Assignee: MESOBLAST, INC.
    Inventor: Peter Ghosh
  • Multipotential Expanded Mesenchymal Precursor Cell Progeny (MEMP) and Uses Thereof
    Publication number: 20240101961
    Abstract: The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1bri and ALP. The present invention also relates to methods for producing MEMP's and to uses of MEMP's for therapeutic applications.
    Type: Application
    Filed: November 28, 2023
    Publication date: March 28, 2024
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino
  • REPAIR AND/OR RECONSTRUCTION OF INVERTEBRAL DISCS
    Publication number: 20240075075
    Abstract: This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1+ multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.
    Type: Application
    Filed: September 1, 2023
    Publication date: March 7, 2024
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • METHODS OF TREATING OR PREVENTING RESPIRATORY CONDITIONS
    Publication number: 20240024366
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: August 8, 2023
    Publication date: January 25, 2024
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • METHOD OF TREATING GRAFT VERSUS HOT DISEASE
    Publication number: 20230346846
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: March 29, 2023
    Publication date: November 2, 2023
    Applicant: Mesoblast Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • TREATMENT OF EXCESSIVE NEOVASCULARIZATION
    Publication number: 20230165901
    Abstract: The present invention relates to methods of treating or preventing angiogenesis-related diseases by the administration of stem cells and/or progeny cells thereof.
    Type: Application
    Filed: September 1, 2022
    Publication date: June 1, 2023
    Applicant: Mesoblast, Inc.
    Inventor: Piroska Elizabeth Rakoczy
  • REPAIR AND/OR RECONSTITUTION OF INVERTEBRAL DISCS
    Publication number: 20230079121
    Abstract: This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1? multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.
    Type: Application
    Filed: July 28, 2022
    Publication date: March 16, 2023
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • METHODS OF GENERATING, REPAIRING AND/OR MAINTAINING CONNECTIVE TISSUE IN VIVO
    Publication number: 20220354902
    Abstract: This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.
    Type: Application
    Filed: July 26, 2022
    Publication date: November 10, 2022
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • Multipotential Expanded Mesenchymal Precursor Cell Progeny (MEMP) and Uses Thereof
    Publication number: 20210355447
    Abstract: The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1bri and ALP. The present invention also relates to methods for producing MEMP's and to uses of MEMP's for therapeutic applications.
    Type: Application
    Filed: July 7, 2021
    Publication date: November 18, 2021
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino
  • Methods for increasing osteoblastic function
    Patent number: 11135249
    Abstract: This application provides methods for treating a human subject suffering from a bone fracture by administering to the subject a population of cells enriched from STRO-1+ multipotential cells and/or multipotential progeny of such cells.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: October 5, 2021
    Assignee: MESOBLAST, INC
    Inventors: Silviu Itescu, Ravi Krishnan
  • METHODS OF TREATING OR PREVENTING NEUROLOGICAL DISEASES
    Publication number: 20210169940
    Abstract: The present disclosure provides a method for treating an inflammatory neurological disease comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 10, 2021
    Applicant: Mesoblast, Inc.
    Inventor: Claude Bernard
  • METHOD OF TREATING GRAFT VERSUS HOST DISEASE
    Publication number: 20210085723
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 25, 2021
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Method of treating graft versus host disease
    Patent number: 10849932
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: December 1, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Michael David Schuster
  • ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE
    Publication number: 20200332023
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Application
    Filed: May 5, 2020
    Publication date: October 22, 2020
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, John Paul Simmons
  • METHODS OF TREATING OR PREVENTING RESPIRATORY CONDITIONS
    Publication number: 20200289578
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • Methods of treating or preventing respiratory conditions
    Patent number: 10688134
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: June 23, 2020
    Assignee: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • METHODS OF GENERATING, REPAIRING AND/OR MAINTAINING CONNECTIVE TISSUE IN VIVO
    Publication number: 20200101118
    Abstract: This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • Methods of treating or preventing rheumatic disease
    Patent number: 10596199
    Abstract: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: March 24, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Peter Ghosh, Silviu Itescu
  • Method of increasing proliferation of bone marrow mononuclear cells expressing STRO1-
    Patent number: 10544394
    Abstract: The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: January 28, 2020
    Assignee: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino