Patents Assigned to Mesoblast, Inc.
  • ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE
    Publication number: 20260109783
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Application
    Filed: March 14, 2025
    Publication date: April 23, 2026
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, Paul John Simmons
  • Repair and/or reconstruction of invertebral discs
    Patent number: 12558382
    Abstract: This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1+ multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: February 24, 2026
    Assignee: MESOBLAST, INC.
    Inventor: Peter Ghosh
  • PRODUCTION OF REPROGRAMMED PLURIPOTENT CELLS
    Publication number: 20250257328
    Abstract: The present invention provides a method of producing a reprogrammed cell, said method comprising exposing Stro-1+ multipotential cells and/or progeny cells thereof to one or more potency-determining factors under conditions sufficient to reprogram the cells. The present invention also provides cells produced by such a method and cells differentiated therefrom in addition to various uses of those cells.
    Type: Application
    Filed: April 11, 2025
    Publication date: August 14, 2025
    Applicant: Mesoblast, Inc.
    Inventor: Silviu Itescu
  • Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
    Patent number: 12275801
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: April 15, 2025
    Assignee: MESOBLAST, INC.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, John Paul Simmons
  • Methods of generating, repairing and/or maintaining connective tissue in vivo
    Patent number: 12220433
    Abstract: This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: February 11, 2025
    Assignee: MESOBLAST, INC.
    Inventor: Peter Ghosh
  • Multipotential Expanded Mesenchymal Precursor Cell Progeny (MEMP) and Uses Thereof
    Publication number: 20240101961
    Abstract: The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1bri and ALP. The present invention also relates to methods for producing MEMP's and to uses of MEMP's for therapeutic applications.
    Type: Application
    Filed: November 28, 2023
    Publication date: March 28, 2024
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino
  • REPAIR AND/OR RECONSTRUCTION OF INVERTEBRAL DISCS
    Publication number: 20240075075
    Abstract: This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1+ multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.
    Type: Application
    Filed: September 1, 2023
    Publication date: March 7, 2024
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • METHODS OF TREATING OR PREVENTING RESPIRATORY CONDITIONS
    Publication number: 20240024366
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: August 8, 2023
    Publication date: January 25, 2024
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • TREATMENT OF EXCESSIVE NEOVASCULARIZATION
    Publication number: 20230165901
    Abstract: The present invention relates to methods of treating or preventing angiogenesis-related diseases by the administration of stem cells and/or progeny cells thereof.
    Type: Application
    Filed: September 1, 2022
    Publication date: June 1, 2023
    Applicant: Mesoblast, Inc.
    Inventor: Piroska Elizabeth Rakoczy
  • REPAIR AND/OR RECONSTITUTION OF INVERTEBRAL DISCS
    Publication number: 20230079121
    Abstract: This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1? multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.
    Type: Application
    Filed: July 28, 2022
    Publication date: March 16, 2023
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • METHODS OF GENERATING, REPAIRING AND/OR MAINTAINING CONNECTIVE TISSUE IN VIVO
    Publication number: 20220354902
    Abstract: This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.
    Type: Application
    Filed: July 26, 2022
    Publication date: November 10, 2022
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • Multipotential Expanded Mesenchymal Precursor Cell Progeny (MEMP) and Uses Thereof
    Publication number: 20210355447
    Abstract: The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1bri and ALP. The present invention also relates to methods for producing MEMP's and to uses of MEMP's for therapeutic applications.
    Type: Application
    Filed: July 7, 2021
    Publication date: November 18, 2021
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino
  • METHODS OF TREATING OR PREVENTING NEUROLOGICAL DISEASES
    Publication number: 20210169940
    Abstract: The present disclosure provides a method for treating an inflammatory neurological disease comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 10, 2021
    Applicant: Mesoblast, Inc.
    Inventor: Claude Bernard
  • METHOD OF TREATING GRAFT VERSUS HOST DISEASE
    Publication number: 20210085723
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 25, 2021
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Method of treating graft versus host disease
    Patent number: 10849932
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: December 1, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Michael David Schuster
  • ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE
    Publication number: 20200332023
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Application
    Filed: May 5, 2020
    Publication date: October 22, 2020
    Applicant: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, John Paul Simmons
  • METHODS OF TREATING OR PREVENTING RESPIRATORY CONDITIONS
    Publication number: 20200289578
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • Methods of treating or preventing respiratory conditions
    Patent number: 10688134
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: June 23, 2020
    Assignee: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • METHODS OF GENERATING, REPAIRING AND/OR MAINTAINING CONNECTIVE TISSUE IN VIVO
    Publication number: 20200101118
    Abstract: This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Applicant: Mesoblast, Inc.
    Inventor: Peter Ghosh
  • Methods of treating or preventing rheumatic disease
    Patent number: 10596199
    Abstract: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: March 24, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Peter Ghosh, Silviu Itescu